Mycamine

DRUG DESCRIPTION

Mycamine is a sterile, lyophilized product for intravenous (IV) infusion that contains micafungin sodium. Micafungin sodium is a semisynthetic lipopeptide (echinocandin) synthesized by a chemical modification of a fermentation product of Coleophoma empetri F-l 1899. Micafungin inhibits the synthesis of 1, 3-?-D-glucan, an integral component of the fungal cell wall.

Each single-use vial contains 50 mg or 100 mg micafungin sodium, 200 mg lactose, with citric acid and/or sodium hydroxide (used for pH adjustment). Mycamine must be diluted with 0.9% Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP [see DOSAGE AND ADMINISTRATION]. Following reconstitution with 0.9% Sodium Chloride Injection, USP, the resulting pH of the solution is between 5-7.

Micafungin sodium is chemically designated as:

Pneumocandin A0, 1 -[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy) phenyl]-3- isoxazolyl] benzoyl]-L-ornithine]-4-[(45)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy) phenyl]-L- threonine]-, monosodium salt.

The chemical structure of micafungin sodium is:

MYCAMEVE (micafungin sodium) Formula Illustration

The empirical/molecular formula is C56H70N9NaO23S and the formula weight is 1292.26.

Micafungin sodium is a light-sensitive, hygroscopic white powder that is freely soluble in water, isotonic sodium chloride solution, N,N-dimethylformamide and dimethylsulfoxide, slightly soluble in methyl alcohol, and practically insoluble in acetonitrile, ethyl alcohol (95%), acetone, diethyl ether and n-hexane.

What are the possible side effects of micafungin (Mycamine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • pale or yellowed skin, dark colored urine, confusion or weakness;
  • stomach pain, itching, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • fever, chills, body aches, flu symptoms;
  • easy bruising or bleeding;
  • urinating less than usual or not at...

Read All Potential Side Effects and See Pictures of Mycamine

What are the precautions when taking micafungin sodium (Mycamine)?

Before using micafungin, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, blood disorders (e.g., anemia, decreased bone marrow function).

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before...

Read All Potential Precautions of Mycamine


Mycamine Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, diarrhea, headache, trouble sleeping, or irritation at the site of injection may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: signs of infection (e.g., persistent sore throat, pain during urination), chills, fever, dark urine, persistent nausea/vomiting, stomach/abdominal pain, yellowing of eyes/skin, easy bleeding/bruising, unusual fatigue, fast/pounding heartbeat, change in the amount of urine.

A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using micafungin, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, blood disorders (e.g., anemia, decreased bone marrow function).

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Mycamine Patient Information Including Side Effects

Brand Names: Mycamine

Generic Name: micafungin (Pronunciation: MYE ka FUN jen)

  • What is micafungin (Mycamine)?
  • What are the possible side effects of micafungin (Mycamine)?
  • What is the most important information I should know about micafungin (Mycamine)?
  • What should I discuss with my healthcare provider before receiving micafungin (Mycamine)?
  • How is micafungin given (Mycamine)?
  • What happens if I miss a dose (Mycamine)?
  • What happens if I overdose (Mycamine)?
  • What should I avoid while using micafungin (Mycamine)?
  • What other drugs will affect micafungin (Mycamine)?
  • Where can I get more information?

What is micafungin (Mycamine)?

Micafungin is an antifungal antibiotic.

Micafungin is used to treat infections caused by the Candida fungus. Micafungin is also used to prevent Candida fungal infections in stem cell transplant patients.

Micafungin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of micafungin (Mycamine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • pale or yellowed skin, dark colored urine, confusion or weakness;
  • stomach pain, itching, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • fever, chills, body aches, flu symptoms;
  • easy bruising or bleeding;
  • urinating less than usual or not at all;
  • drowsiness, mood changes, increased thirst, loss of appetite, nausea and vomiting;
  • uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; or
  • swelling of your hands or feet.

Less serious side effects may include:

  • warmth, redness, or tingly feeling under your skin;
  • mild nausea, vomiting, or stomach pain;
  • diarrhea, constipation, indigestion;
  • headache;
  • sleep problems (insomnia);
  • mild itching or skin rash; or
  • pain, swelling, or tenderness where the medicine was injected.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about micafungin (Mycamine)?

You should not use this medication if you are allergic to micafungin.

Before using micafungin, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.

Before receiving micafungin, tell your doctor if you are also using sirolimus (Rapamune), itraconazole (Sporanox), or nifedipine (Adalat, Procardia).

Micafungin is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to use your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.

You may need to receive this medication for several weeks.

Related Drug Centers
  • Mycamine


Related Drugs Index: