Mesnex

DRUG DESCRIPTION

Mesnex« (mesna) is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide (IFEX«).The active ingredient mesna is a synthetic sulfhydryl compound designated as sodium-2-mercaptoethane sulfonate with a molecular formula of C2H5NaO3S2 and a molecular weight of 164.18.Its structural formula is as follows:

HS-CH2-CH2SO3ľNa+

Mesnex (mesna) Injection is a sterile, nonpyrogenic, aqueous solution of clear and colorless appearance in clear glass multi-dose vials for intravenous administration.Mesnex Injection contains 100 mg/mL mesna, 0.25 mg/mL edetate disodium and sodium hydroxide for pH adjustment.Mesnex (mesna) Injection multidose vials also contain 10.4 mg of benzyl alcohol as a preservative. The solution has a pH range of 7.5-8.5.

Mesnex (mesna) Tablets are white, oblong, scored biconvex film coated tablets with the imprint M4. They contain 400 mg mesna. Excipients include lactose, microcrystalline cellulose, calcium phosphate, cornstarch, povidone, magnesium stearate, hydroxypropylmethylcellulose, polyethylene glycol, titanium dioxide, and simethicone.

What are the possible side effects of mesna (Mesnex)?

Seek emergency medical attention or contact your healthcare provider immediately if you experience any of the following serious side effects:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
  • pink or red colored urine.

Other less serious side effects may be more likely to occur. Continue to take mesna, and contact your doctor if you experience any of the following side effects:

  • nausea or vomiting;
  • decreased...

Read All Potential Side Effects and See Pictures of Mesnex

What are the precautions when taking mesna (Mesnex)?

Before taking mesna, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: overactive immune system diseases (autoimmune disorders) that may increase your risk for a mesna allergy (e.g., rheumatoid arthritis, lupus, nephritis).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Kidney function declines as you grow older. This medication is...

Read All Potential Precautions of Mesnex


Mesnex Consumer (continued)

SIDE EFFECTS: Headache, flushing, dizziness, drowsiness, nausea, vomiting, loss of appetite, diarrhea, constipation, sensitive skin, or flu-like symptoms (e.g., sore throat, fever, chills, shivering, cough, body aches) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: chest pain, fast heartbeat, swelling ankles/feet, muscle weakness.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking mesna, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: overactive immune system diseases (autoimmune disorders) that may increase your risk for a mesna allergy (e.g., rheumatoid arthritis, lupus, nephritis).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Kidney function declines as you grow older. This medication is removed by the kidneys. The elderly may be more sensitive to the effects of this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Since this medication is given with a cancer chemotherapy drug, breast-feeding while using mesna is not recommended. Consult your doctor before breast-feeding.


Mesnex Patient Information Including Side Effects

Brand Names: Mesnex

Generic Name: mesna (Pronunciation: MEZ nah)

  • What is mesna (Mesnex)?
  • What are the possible side effects of mesna (Mesnex)?
  • What is the most important information I should know about mesna (Mesnex)?
  • What should I discuss with my healthcare provider before taking mesna (Mesnex)?
  • How should I take mesna (Mesnex)?
  • What happens if I miss a dose (Mesnex)?
  • What happens if I overdose (Mesnex)?
  • What should I avoid while taking mesna (Mesnex)?
  • What other drugs will affect mesna (Mesnex)?
  • Where can I get more information?

What is mesna (Mesnex)?

Mesna is detoxifying agent. It reduces the harmful effects of certain metabolites (breakdown products) of the cancer chemotherapy medicine ifosfamide (Ifex).

Mesna is used to prevent bleeding in the bladder (hemorrhagic cystitis) during chemotherapy with ifosfamide (Ifex).

Mesna may also be used for purposes other than those listed here.

What are the possible side effects of mesna (Mesnex)?

Seek emergency medical attention or contact your healthcare provider immediately if you experience any of the following serious side effects:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
  • pink or red colored urine.

Other less serious side effects may be more likely to occur. Continue to take mesna, and contact your doctor if you experience any of the following side effects:

  • nausea or vomiting;
  • decreased appetite;
  • stomach pain;
  • diarrhea;
  • dizziness;
  • flushing;
  • fever;
  • sensitive skin or skin rash;
  • paleness of the skin;
  • sleepiness;
  • coughing or cold symptoms;
  • pain, redness, or irritation at the injection site;
  • swelling or water retention; or
  • low blood pressure.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about mesna (Mesnex)?

It is important to drink at least one quart (4 cups) of liquid each day during treatment with mesna, whether it is taken by mouth or by injection.

If you see blood in the urine or notice that it has a pink or red color, contact your doctor as soon as possible. Some foods or dyes may cause a red color in the urine, however it will be necessary to determine if the color is due to blood in the urine.

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