M-M-R II

DRUG DESCRIPTION

M-M-R II (Measles, Mumps, and Rubella Virus Vaccine Live) is a live virus vaccine for vaccination against measles (rubeola), mumps, and rubella (German measles).

M-M-R II (measles, mumps, and rubella virus vaccine live) is a sterile lyophilized preparation of (1) ATTENUVAX (Measles Virus Vaccine Live), a more attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture; (2) MUMPSVAX (Mumps Virus Vaccine Live), the Jeryl Lynn (B level) strain of mumps virus propagated in chick embryo cell culture; and (3) MERUVAX II (Rubella Virus Vaccine Live), the Wistar RA 27/3 strain of live attenuated rubella virus propagated in WI-38 human diploid lung fibroblasts.1,2

The growth medium for measles and mumps is Medium 199 (a buffered salt solution containing vitamins and amino acids and supplemented with fetal bovine serum) containing SPGA (sucrose, phosphate, glutamate, and recombinant human albumin) as stabilizer and neomycin.

The growth medium for rubella is Minimum Essential Medium (MEM) [a buffered salt solution containing vitamins and amino acids and supplemented with fetal bovine serum] containing recombinant human albumin and neomycin. Sorbitol and hydrolyzed gelatin stabilizer are added to the individual virus harvests.

The cells, virus pools, and fetal bovine serum are all screened for the absence of adventitious agents. The reconstituted vaccine is for subcutaneous administration. Each 0.5 mL dose contains not less than 1,000 TCID50 (tissue culture infectious doses) of measles virus; 12,500 TCID50 of mumps virus; and 1,000 TCID50 of rubella virus. Each dose of the vaccine is calculated to contain sorbitol (14.5 mg), sodium phosphate, sucrose (1.9 mg), sodium chloride, hydrolyzed gelatin (14.5 mg), recombinant human albumin ( ? 0.3 mg), fetal bovine serum ( < 1 ppm), other buffer and media ingredients and approximately 25 mcg of neomycin. The product contains no preservative.

Before reconstitution, the lyophilized vaccine is a light yellow compact crystalline plug. M-M-R II (measles, mumps, and rubella virus vaccine live) , when reconstituted as directed, is clear yellow.

What are the possible side effects of measles, mumps, and rubella vaccines (M-M-R II)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but...

Read All Potential Side Effects and See Pictures of M-M-R II

What are the precautions when taking measles, mumps, and rubella virus vaccine live (M-M-R II)?

Before receiving the vaccine, tell your doctor or pharmacist if you are allergic to it; or to eggs; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as HIV infection), cancer (such as leukemia, lymphoma), low platelet counts (thrombocytopenia), brain disorders (such as seizures, head injury), blood/plasma transfusions.

This vaccine is not recommended for use during pregnancy. Also, women of childbearing age should avoid becoming pregnant for 3 months after receiving the...

Read All Potential Precautions of M-M-R II

What are the possible side effects of measles, mumps, and rubella vaccines (M-M-R II)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but...

Read All Potential Side Effects and See Pictures of M-M-R II

What are the precautions when taking measles, mumps, and rubella virus vaccine live (M-M-R II)?

Before receiving the vaccine, tell your doctor or pharmacist if you are allergic to it; or to eggs; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as HIV infection), cancer (such as leukemia, lymphoma), low platelet counts (thrombocytopenia), brain disorders (such as seizures, head injury), blood/plasma transfusions.

This vaccine is not recommended for use during pregnancy. Also, women of childbearing age should avoid becoming pregnant for 3 months after receiving the...

Read All Potential Precautions of M-M-R II

What are the possible side effects of measles, mumps, and rubella vaccines (M-M-R II)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but...

Read All Potential Side Effects and See Pictures of M-M-R II

What are the precautions when taking measles, mumps, and rubella virus vaccine live (M-M-R II)?

Before receiving the vaccine, tell your doctor or pharmacist if you are allergic to it; or to eggs; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as HIV infection), cancer (such as leukemia, lymphoma), low platelet counts (thrombocytopenia), brain disorders (such as seizures, head injury), blood/plasma transfusions.

This vaccine is not recommended for use during pregnancy. Also, women of childbearing age should avoid becoming pregnant for 3 months after receiving the...

Read All Potential Precautions of M-M-R II

What are the possible side effects of measles, mumps, and rubella vaccines (M-M-R II)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but...

Read All Potential Side Effects and See Pictures of M-M-R II

What are the precautions when taking measles, mumps, and rubella virus vaccine live (M-M-R II)?

Before receiving the vaccine, tell your doctor or pharmacist if you are allergic to it; or to eggs; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as HIV infection), cancer (such as leukemia, lymphoma), low platelet counts (thrombocytopenia), brain disorders (such as seizures, head injury), blood/plasma transfusions.

This vaccine is not recommended for use during pregnancy. Also, women of childbearing age should avoid becoming pregnant for 3 months after receiving the...

Read All Potential Precautions of M-M-R II


M-M-R II Consumer (continued)

SIDE EFFECTS: Pain/redness/swelling at the injection site, fever, or mild rash may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: joint pain/stiffness, muscle pain, numb/tingling skin.

Tell your doctor immediately if any of these rare but serious side effects occur: easy bruising/bleeding, seizures, mental/mood changes (such as confusion).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Contact your doctor for medical advice about side effects. The following numbers do not provide medical advice, but in the US, you may report side effects to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967. In Canada, you may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before receiving the vaccine, tell your doctor or pharmacist if you are allergic to it; or to eggs; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as HIV infection), cancer (such as leukemia, lymphoma), low platelet counts (thrombocytopenia), brain disorders (such as seizures, head injury), blood/plasma transfusions.

This vaccine is not recommended for use during pregnancy. Also, women of childbearing age should avoid becoming pregnant for 3 months after receiving the vaccine. Consult your doctor for more details.

The rubella vaccine virus passes into breast milk. It is unknown if the measles or mumps vaccine virus passes into breast milk. Consult your doctor before breast-feeding.


M-M-R II Patient Information Including Side Effects

Brand Names: M-M-R II

Generic Name: measles, mumps, and rubella (MMR) vaccine (Pronunciation: MEE zels, MUMPS, and roo BEL a)

  • What is measles, mumps, and rubella vaccine (M-M-R II)?
  • What are the possible side effects of measles, mumps, and rubella vaccines (M-M-R II)?
  • What is the most important information I should know about this vaccine (M-M-R II)?
  • What should I discuss with my healthcare provider before receiving this vaccine (M-M-R II)?
  • How is this vaccine given (M-M-R II)?
  • What happens if I miss a dose (M-M-R II)?
  • What happens if I overdose (M-M-R II)?
  • What should I avoid before or after receiving this vaccine (M-M-R II)?
  • What other drugs will affect measles, mumps, and rubella vaccine (M-M-R II)?
  • Where can I get more information?

What is measles, mumps, and rubella vaccine (M-M-R II)?

Measles, mumps, and rubella are serious diseases caused by viruses. They are spread from person to person through the air.

Measles virus can cause minor symptoms such as skin rash, cough, runny nose, eye irritation, or mild fever. It can also cause more serious symptoms such as ear infection, pneumonia, seizures, permanent brain damage, or death.

Mumps virus causes fever, headache, and swollen glands, but more serious symptoms include hearing loss, and painful swelling of the testicles or ovaries. Mumps can cause breathing problems or meningitis, and these infections can be fatal.

Rubella virus (also called German Measles) causes skin rash, mild fever, and joint pain. Becoming infected with rubella during pregnancy can result in a miscarriage or serious birth defects.

The measles, mumps, and rubella vaccine is used to help prevent these diseases in children and adults.

This vaccine works by exposing you to a small dose of the virus or a protein from the virus, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body.

Measles, mumps, and rubella vaccine is for use in children between the ages of 12 months and 6 years old, and in adults who have never received the vaccine or had the diseases.

Like any vaccine, the measles, mumps, and rubella vaccine may not provide protection from disease in every person.

What are the possible side effects of measles, mumps, and rubella vaccines (M-M-R II)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • problems with hearing or vision;
  • extreme drowsiness, fainting;
  • easy bruising or bleeding, unusual weakness;
  • seizure (black-out or convulsions); or
  • high fever (within a few hours or a few days after the vaccine).

Less serious side effects include:

  • redness, pain, swelling, or a lump where the shot was given;
  • headache, dizziness;
  • low fever;
  • joint or muscle pain; or
  • nausea, vomiting, diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

What is the most important information I should know about this vaccine (M-M-R II)?

The measles, mumps, and rubella (MMR) vaccine is given in a series of shots. The first shot is usually given to a child who is 12 to 15 month old. The booster shots are then given between 4 and 6 years of age. At least 28 days (4 weeks) should pass between the first and second doses of this vaccine.

Adults born after 1956 should receive at least one MMR vaccination if they have never had the diseases or received an MMR vaccine during their lifetime.

Your individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by the health department of the state you live in.

Be sure you receive all recommended doses of this vaccine. If you do not receive the full series of vaccines, you may not be fully protected against the disease.

You can still receive a vaccine if you have a cold or fever. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

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