Myochrysine

DRUG DESCRIPTION

Gold Sodium Thiomalate is a sterile aqueous solution. It contains 0.5 percent BENZYL alcohol added as a preservative. The pH of the product is 5.8 to 6.5.

Gold Sodium Thiomalate is a mixture of the mono- and di-sodium salts of gold thiomalic acid. The structural formula is:

MYOCHRYSINE (Gold Sodium Thiomalate) Structural Formula Illustration

mercaptobutanedioic acid, monogold (1+) sodium salt

The molecular weight for C4H3AuNa2O4S (the disodium salt) is 390.07 and for C4H4AuNaO4S (the mono-sodium salt) is 368.09.

Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL.

What are the possible side effects of gold sodium thiomalate (Myochrysine)?

Stop taking gold sodium thiomalate and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

Rarely, other serious side effects may also occur. Call your doctor immediately if you experience any of the following:

  • itching or a rash;
  • a sore mouth, indigestion, or a metallic taste in the mouth;
  • severe or bloody diarrhea;
  • easy bruising or a nosebleed;
  • ...

Read All Potential Side Effects and See Pictures of Myochrysine

What are the precautions when taking gold sodium thiomalate (Myochrysine)?

Before using gold sodium thiomalate injection, tell your doctor or pharmacist if you are allergic to it; or to any other gold or heavy metal compound; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of reaction to gold compound (e.g., blood disorders, kidney problems, lung problems, severe rash, stomach/intestinal problems), SLE (systemic lupus erythematosus).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (e.g.,...

Read All Potential Precautions of Myochrysine


Myochrysine Consumer (continued)

SIDE EFFECTS: See also How to Use section.

Flushing, dizziness, headache, nausea, vomiting, weakness, and sweating may occur soon after the injection. Increased joint pain may occur 1-2 days after your injection. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: eye redness/pain, fainting, hair loss, mental/mood changes (e.g., confusion, hallucinations), numbness/tingling of arms/legs, seizure.

This medication may cause mouth/lip/throat sores (stomatitis). Tell your doctor if you notice a metallic taste in your mouth. This could be the first sign of stomatitis.

Tell your doctor immediately if any of these rare but very serious side effects occur: difficult/painful breathing, signs of low blood count (e.g., fast/pounding heartbeat, pale skin, unusual tiredness), easy bleeding/bruising, black/bloody stools, persistent cough, severe diarrhea, signs of infection (e.g., fever, persistent sore throat), gray/blue skin color, severe stomach/abdominal pain, unusual tiredness, change in the amount/color of urine, vaginal itching/sores, vomit that looks like coffee grounds, yellowing eyes/skin.

A very serious allergic reaction to this drug is uncommon. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: itching/swelling (especially of the face/tongue/throat), rash, severe dizziness, trouble breathing.

Skin rash is common with this medication and can be serious. Itching is often the first sign of a severe allergic reaction. Therefore, seek immediate medical attention if you develop any rash or itching.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using gold sodium thiomalate injection, tell your doctor or pharmacist if you are allergic to it; or to any other gold or heavy metal compound; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of reaction to gold compound (e.g., blood disorders, kidney problems, lung problems, severe rash, stomach/intestinal problems), SLE (systemic lupus erythematosus).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (e.g., chest pain, heart attack, stroke), blood disorders (e.g., bleeding problems, bone marrow depression), colitis/inflammatory bowel disease, diabetes, eczema, heart problems (e.g., congestive heart failure), certain lung problem (fibrosis), very high blood pressure, kidney disease, liver disease, recent radiation therapy.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. If you become pregnant or think you may be pregnant, inform your doctor immediately. Consult your doctor for more details.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.


Myochrysine Patient Information Including Side Effects

Brand Names: Myochrysine

Generic Name: gold sodium thiomalate (Pronunciation: gold SOE dee um thye OH ma late)

  • What is gold sodium thiomalate (Myochrysine)?
  • What are the possible side effects of gold sodium thiomalate (Myochrysine)?
  • What is the most important information I should know about gold sodium thiomalate (Myochrysine)?
  • What should I discuss with my healthcare provider before taking gold sodium thiomalate (Myochrysine)?
  • How should I take gold sodium thiomalate (Myochrysine)?
  • What happens if I miss a dose (Myochrysine)?
  • What happens if I overdose (Myochrysine)?
  • What should I avoid while using gold sodium thiomalate (Myochrysine)?
  • What other drugs will affect gold sodium thiomalate (Myochrysine)?
  • Where can I get more information?

What is gold sodium thiomalate (Myochrysine)?

Gold sodium thiomalate is a form of gold. Gold suppresses the inflammatory process.

Gold sodium thiomalate is used as an injection to treat adult and juvenile rheumatoid arthritis.

Gold sodium thiomalate may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of gold sodium thiomalate (Myochrysine)?

Stop taking gold sodium thiomalate and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

Rarely, other serious side effects may also occur. Call your doctor immediately if you experience any of the following:

  • itching or a rash;
  • a sore mouth, indigestion, or a metallic taste in the mouth;
  • severe or bloody diarrhea;
  • easy bruising or a nosebleed;
  • yellow skin or eyes;
  • abdominal pain;
  • seizures;
  • confusion or hallucinations;
  • blood in vomit or stools;
  • blood in the urine or painful urination; or
  • shortness of breath; or
  • weakness, dizziness, nausea, vomiting, sweating, fainting, and flushing shortly after an injection.

In addition, less serious side effects may be more likely to occur. Talk to your doctor if you experience any of the following:

  • diarrhea or loose stools;
  • nausea, stomach upset, decreased appetite;
  • changes in taste; or
  • sores or ulcers in the mouth.

Arthritic symptoms may appear to worsen for 1 to 2 days following an injection and should decrease with subsequent injections.

Gold sodium thiomalate can cause serious side effects involving white and red blood cells. Your doctor will want to test your blood and urine before each injection to monitor any changes before they become dangerous.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about gold sodium thiomalate (Myochrysine)?

Contact your doctor immediately if you experience itching, a rash, a sore mouth, indigestion, a metallic taste in the mouth, severe or bloody diarrhea, easy bruising, or a nosebleed. These could be early signs of a toxic effect.

In rare cases, exposure to sunlight may cause areas of the skin to turn a bluish-gray color. To lessen this effect, minimize exposure to sunlight and wear a sunscreen and protective clothing when exposure to the sun is unavoidable.

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