Merrem I.V.

DRUG DESCRIPTION

MERREM® I.V. (meropenem for injection) is a sterile, pyrogen-free, synthetic, broad-spectrum, carbapenem antibiotic for intravenous administration. It is (4R,5S,6S)-3-[[(3S,5S)-5- (Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1- azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate. Its empirical formula is C17H25N3O5S•3H2O with a molecular weight of 437.52. Its structural formula is:

MERREM (meropenem) structural formula illustration

MERREM I.V. (meropenem) is a white to pale yellow crystalline powder. The solution varies from colorless to yellow depending on the concentration. The pH of freshly constituted solutions is between 7.3 and 8.3. Meropenem is soluble in 5% monobasic potassium phosphate solution, sparingly soluble in water, very slightly soluble in hydrated ethanol, and practically insoluble in acetone or ether.

When constituted as instructed (see DOSAGE AND ADMINISTRATION; PREPARATION OF SOLUTION), each 1 g MERREM I.V. vial will deliver 1 g of meropenem and 90.2 mg of sodium as sodium carbonate (3.92 mEq). Each 500 mg MERREM I.V. vial will deliver 500 mg meropenem and 45.1 mg of sodium as sodium carbonate (1.96 mEq).

What are the possible side effects of meropenem (Merrem)?

If you experience a rare but serious side effects, stop taking meropenem and seek emergency medical attention or contact your doctor immediately:

  • allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
  • seizures;
  • severe or watery diarrhea;
  • a skin rash;
  • unusual tiredness or weakness; or
  • unusual bleeding or bruising.

Other less serious side effects may be more likely to occur. Continue to use meropenem and...

Read All Potential Side Effects and See Pictures of Merrem I.V. »

What are the precautions when taking meropenem (Merrem I.V.)?

Before using meropenem, tell your doctor or pharmacist if you are allergic to it; or to penicillins or cephalosporins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., seizures, head injury, tumor), kidney disease, stomach/intestinal diseases (e.g., colitis).

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.

Tell your doctor if you are pregnant before using this medication.

It is not known...

Read All Potential Precautions of Merrem I.V. »


Merrem I.V. Consumer (continued)

SIDE EFFECTS: Swelling, redness, pain, or soreness at the injection site may occur. This medication may also infrequently cause upset stomach, headache, nausea, vomiting, constipation, or diarrhea. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, hearing changes (e.g., decreased hearing, ringing in the ears), mental/mood changes (e.g., confusion), swollen tongue.

Get medical help right away if any of these rare but very serious side effects occur: seizures, unusual weakness.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using meropenem, tell your doctor or pharmacist if you are allergic to it; or to penicillins or cephalosporins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., seizures, head injury, tumor), kidney disease, stomach/intestinal diseases (e.g., colitis).

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.

Tell your doctor if you are pregnant before using this medication.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Merrem I.V. Patient Information Including Side Effects

Brand Names: Merrem

Generic Name: meropenem (Pronunciation: mer oh PEH nem)

  • What is meropenem (Merrem I.V.)?
  • What are the possible side effects of meropenem (Merrem I.V.)?
  • What is the most important information I should know about meropenem (Merrem I.V.)?
  • What should I discuss with my healthcare provider before taking meropenem (Merrem I.V.)?
  • How should I take meropenem (Merrem I.V.)?
  • What happens if I miss a dose (Merrem I.V.)?
  • What happens if I overdose (Merrem I.V.)?
  • What should I avoid while taking meropenem (Merrem I.V.)?
  • What other drugs will affect meropenem (Merrem I.V.)?
  • Where can I get more information?

What is meropenem (Merrem I.V.)?

Meropenem is an antibiotic. It fights bacteria in the body.

Meropenem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections.

Meropenem may also be used for purposes other than those listed here.

What are the possible side effects of meropenem (Merrem I.V.)?

If you experience a rare but serious side effects, stop taking meropenem and seek emergency medical attention or contact your doctor immediately:

  • allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
  • seizures;
  • severe or watery diarrhea;
  • a skin rash;
  • unusual tiredness or weakness; or
  • unusual bleeding or bruising.

Other less serious side effects may be more likely to occur. Continue to use meropenem and talk to your doctor if you experience:

  • nausea or vomiting;
  • diarrhea or constipation;
  • headache; or
  • soreness, redness, or mild swelling at the injection site.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about meropenem (Merrem I.V.)?

Do not take meropenem without first talking to your doctor if you have an allergy to meropenem, imipenem (Primaxin), a penicillin antibiotic, or a cephalosporin antibiotic.

Related Drug Centers
  • Merrem IV


Related Drugs Index: