Demser

DRUG DESCRIPTION

DEMSER* (Metyrosine) is (–)-?-methyl-L-tyrosine or (?-MPT). It has the following structural formula:

DEMSER® 
  (METYROSINE) Structural Formula Illustration

Metyrosine is a white, crystalline compound of molecular weight 195. It is very slightly soluble in water, acetone, and methanol, and insoluble in chloroform and benzene. It is soluble in acidic aqueous solutions. It is also soluble in alkaline aqueous solutions, but is subject to oxidative degradation under these conditions.

DEMSER (metyrosine) is supplied as capsules, for oral administration. Each capsule contains 250 mg metyrosine. Inactive ingredients are colloidal silicon dioxide, gelatin, hydroxypropyl cellulose, magnesium stearate, titanium dioxide, and FD&C Blue 2.

What are the possible side effects of metyrosine (Demser)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • drooling;
  • difficulty speaking;
  • tremors;
  • muscle spasms;
  • disorientation;
  • diarrhea; or
  • painful urination.

Less serious side effects may include:

  • headache;
  • drowsiness;
  • depression,...

Read All Potential Side Effects and See Pictures of Demser »

What are the precautions when taking metyrosine (Demser)?

Before taking metyrosine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, severe loss of body water (dehydration), small amount of urine.

Before having surgery, tell your doctor or dentist that you are taking this medication.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages because alcohol may increase...

Read All Potential Precautions of Demser »


Demser Consumer (continued)

SIDE EFFECTS: Drowsiness, tiredness, dizziness, lightheadedness, dry mouth, and diarrhea may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: difficulty speaking, drooling, unwanted/uncontrolled movements, muscle stiffness, shaking (tremor), decrease in sexual ability, tenderness/swelling of the breast.

Tell your doctor immediately if any of these rare but very serious side effects occur: mental/mood changes (e.g., confusion, depression, severe anxiety), painful urination, pink/bloody urine, change in the amount of urine.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking metyrosine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, severe loss of body water (dehydration), small amount of urine.

Before having surgery, tell your doctor or dentist that you are taking this medication.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages because alcohol may increase dizziness/drowsiness and may also cause you to lose too much body water (become dehydrated).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Demser Patient Information Including Side Effects

Brand Names: Demser

Generic Name: metyrosine (Pronunciation: me TYE roe seen)

  • What is metyrosine (Demser)?
  • What are the possible side effects of metyrosine (Demser)?
  • What is the most important information I should know about metyrosine (Demser)?
  • What should I discuss with my healthcare provider before taking metyrosine (Demser)?
  • How should I take metyrosine (Demser)?
  • What happens if I miss a dose (Demser)?
  • What happens if I overdose (Demser)?
  • What should I avoid while taking metyrosine (Demser)?
  • What other drugs will affect metyrosine (Demser)?
  • Where can I get more information?

What is metyrosine (Demser)?

Metyrosine is used to treat pheochromocytoma (tumor of the adrenal gland).

Metyrosine is given before surgery to control pheochromocytoma, and is also given when surgery is not possible.

Metyrosine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of metyrosine (Demser)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • drooling;
  • difficulty speaking;
  • tremors;
  • muscle spasms;
  • disorientation;
  • diarrhea; or
  • painful urination.

Less serious side effects may include:

  • headache;
  • drowsiness;
  • depression, hallucinations, disorientation, and confusion;
  • stomach upset, vomiting, stomach pain; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about metyrosine (Demser)?

Metyrosine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol. It can increase some of the side effects of metyrosine.

Call your doctor at once if you have confusion, trouble speaking, tremors, drooling, diarrhea, or painful urination.

Drink plenty of fluid every day--at least six to eight full glasses (8 ounces)--to prevent metyrosine crystals from forming in your urine.

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