Methazolamide

DRUG DESCRIPTION

Methazolamide, a sulfonamide derivative, is a white crystalline powder, weakly acidic, and slightly soluble in water, alcohol and acetone. It is available as 25 mg and 50 mg tablets. The chemical name for methazolamide is N -[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H )-ylidene]-acetamide and it has the following structural formula:

Methazolamide Structural Formula Illustration

Methazolamide tablets, USP contain 25mg or 50mg of methazolamide. Inactive ingredients: croscarmellose sodium, hydroxypropyl methylcellulose, lactose (monohydrate), magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate.

What are the possible side effects of methazolamide (Glauctabs, MZM, Neptazane)?

If you experience any of the following serious side effects, stop taking methazolamide and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • a sore throat or a fever;
  • unusual bleeding or bruising;
  • side or groin pain;
  • tingling or tremors in the hands or feet; or
  • a rash.

Other, less serious side effects may...

Read All Potential Side Effects and See Pictures of Methazolamide

What are the precautions when taking methazolamide (Methazolamide)?

Before taking methazolamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: adrenal gland problems (e.g., Addison's disease), severe kidney disease, severe liver disease (e.g., cirrhosis), untreated mineral imbalance (e.g., low sodium/potassium, hyperchloremic acidosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e.g., chronic obstructive pulmonary disease-COPD,...

Read All Potential Precautions of Methazolamide


Methazolamide Consumer (continued)

SIDE EFFECTS: Nausea, loss of appetite, change in taste, vomiting, diarrhea, frequent urination, dizziness, drowsiness, or tiredness may occur. These effects may be temporary and decrease as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: blood in urine, numbness or tingling of hands/feet, painful urination, ringing in the ears, sudden decrease in amount of urine.

Tell your doctor immediately if any of these rare but very serious side effects occur: confusion, easy bleeding/bruising, fast/pounding heartbeat, persistent nausea/vomiting, signs of infection (e.g., fever, persistent sore throat), seizure, stomach/abdominal pain, dark urine, yellowing of eyes/skin.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking methazolamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: adrenal gland problems (e.g., Addison's disease), severe kidney disease, severe liver disease (e.g., cirrhosis), untreated mineral imbalance (e.g., low sodium/potassium, hyperchloremic acidosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e.g., chronic obstructive pulmonary disease-COPD, emphysema, lung infection), diabetes, gout, kidney problems (e.g., history of kidney stones), overactive thyroid (hyperthyroidism).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.


Methazolamide Patient Information Including Side Effects

Brand Names: Glauctabs, MZM, Neptazane

Generic Name: methazolamide (Pronunciation: meth a ZOLE a mide)

  • What is methazolamide (Methazolamide)?
  • What are the possible side effects of methazolamide (Methazolamide)?
  • What is the most important information I should know about methazolamide (Methazolamide)?
  • What should I discuss with my healthcare provider before taking methazolamide (Methazolamide)?
  • How should I take methazolamide (Methazolamide)?
  • What happens if I miss a dose (Methazolamide)?
  • What happens if I overdose (Methazolamide)?
  • What should I avoid while taking methazolamide (Methazolamide)?
  • What other drugs will affect methazolamide (Methazolamide)?
  • Where can I get more information?

What is methazolamide (Methazolamide)?

Methazolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase is a protein in the body. Methazolamide reduces the activity of this protein.

Methazolamide is used to treat glaucoma. By inhibiting the actions of carbonic anhydrase, methazolamide reduces the amount of fluid produced in the eyes and therefore also reduces pressure.

Methazolamide may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of methazolamide (Methazolamide)?

If you experience any of the following serious side effects, stop taking methazolamide and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • a sore throat or a fever;
  • unusual bleeding or bruising;
  • side or groin pain;
  • tingling or tremors in the hands or feet; or
  • a rash.

Other, less serious side effects may be more likely to occur. Continue to take methazolamide and talk to your doctor if you experience

  • decreased appetite, nausea, vomiting, constipation, diarrhea, or changes in taste;
  • drowsiness, dizziness, fatigue, or weakness;
  • nervousness or tremor;
  • headache or confusion;
  • increased sensitivity of the skin to sunlight;
  • worsening gout;
  • loss of blood sugar control (if you are diabetic);
  • ringing in your ears or hearing problems; or
  • changes in vision.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about methazolamide (Methazolamide)?

Contact your doctor immediately if you experience a sore throat, fever, unusual bleeding or bruising, tingling or tremors in the hands or feet, pain in the side or groin, or a rash. These symptoms could be early signs of a serious side effect.

Use caution when driving, operating machinery, or performing other hazardous activities. Methazolamide may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Avoid prolonged exposure to sunlight. Methazolamide may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

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