Selzentry

DRUG DESCRIPTION

SELZENTRY (maraviroc) is a selective, slowly reversible, small molecule antagonist of the interaction between human CCR5 and HIV-1 gp120. Blocking this interaction prevents CCR5-tropic HIV-1 entry into cells.

SELZENTRY is available as film-coated tablets for oral administration containing either 150 or 300 mg of maraviroc and the following inactive ingredients: dibasic calcium phosphate (anhydrous), magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. The film coat (Opadry® II Blue [85G20583]) contains FD&C blue #2 aluminum lake, soya lecithin, polyethylene glycol (macrogol 3350), polyvinyl alcohol, talc, and titanium dioxide.

Maraviroc is chemically described as 4,4-difluoro-N-{(1S)-3-[exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide.

The molecular formula is C29H41F2N5O and the structural formula is:

SELZENTRY (maraviroc) Structural Formula Illustration

Maraviroc is a white to pale-colored powder with a molecular weight of 513.67. It is highly soluble across the physiological pH range (pH 1.0 to 7.5).

What are the possible side effects of maraviroc (Selzentry)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using maraviroc and call your doctor at once if you have any of these serious side effects:

  • nausea, stomach pain, loss of appetite, skin rash, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • chest pain;
  • feeling like you might pass out;
  • sudden numbness, tingling, or weakness anywhere in your...

Read All Potential Side Effects and See Pictures of Selzentry »

What are the precautions when taking maraviroc (Selzentry)?

Before taking maraviroc, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., previous heart attack), kidney disease, liver problems (including hepatitis B or C infection), low blood pressure.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying...

Read All Potential Precautions of Selzentry »


Selzentry Consumer (continued)

SIDE EFFECTS: See also Warning section.

Cough, stomach pain, tiredness, or muscle/joint pain may occur. Lightheadedness or dizziness while standing may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Seek immediate medical attention if any of these rare but very serious side effects occur: chest/jaw/left arm pain.

If you are taking HIV medications for the first time, you may experience symptoms of an old infection. This may happen as your immune system begins to work better. Symptoms may include: new cough, trouble breathing, fever, new vision problems, new headaches, new skin problems.

Contact your doctor immediately if you have any of these effects.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking maraviroc, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., previous heart attack), kidney disease, liver problems (including hepatitis B or C infection), low blood pressure.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Tell your doctor if you are pregnant before using this medication.

It is not known if this medication passes into breast milk. Because breast milk can transmit HIV, do not breast-feed.


Selzentry Patient Information Including Side Effects

Brand Names: Selzentry

Generic Name: maraviroc (Pronunciation: ma RAV i rok)

  • What is maraviroc (Selzentry)?
  • What are the possible side effects of maraviroc (Selzentry)?
  • What is the most important information I should know about maraviroc (Selzentry)?
  • What should I discuss with my health care provider before taking maraviroc (Selzentry)?
  • How should I take maraviroc (Selzentry)?
  • What happens if I miss a dose (Selzentry)?
  • What happens if I overdose (Selzentry)?
  • What should I avoid while taking maraviroc (Selzentry)?
  • What other drugs will affect maraviroc (Selzentry)?
  • Where can I get more information?

What is maraviroc (Selzentry)?

Maraviroc is an antiviral medication that prevents certain viral cells from multiplying in your body.

Maraviroc is used together with other medications. to treat CCR5-tropic human immunodeficiency virus (HIV) type 1.

Maraviroc is not a cure for HIV or AIDS.

Maraviroc may also be used for purposes not listed in this medication guide.

What are the possible side effects of maraviroc (Selzentry)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using maraviroc and call your doctor at once if you have any of these serious side effects:

  • nausea, stomach pain, loss of appetite, skin rash, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • chest pain;
  • feeling like you might pass out;
  • sudden numbness, tingling, or weakness anywhere in your body;
  • cold sores, sores on your genital or anal area;
  • signs of a new infection, such as fever or chills, cough, or flu symptoms.

Less serious side effects may include:

  • swelling;
  • white patches or sores inside your mouth or on your lips;
  • problems with urination;
  • runny or stuffy nose, sneezing, sore throat;
  • stomach pain, diarrhea;
  • muscle or joint pain;
  • dizziness; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about maraviroc (Selzentry)?

Before taking this medication, tell your doctor if you have kidney disease, liver disease (especially hepatitis B or C), heart disease, low blood pressure, any type of allergy, circulation problems, or if you have ever had a stroke.

There are many other medicines that can interact with maraviroc. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

HIV/AIDS is usually treated with a combination of different drugs. Maraviroc must be given in combination with other antiviral medications. To best treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.

Taking maraviroc will not prevent you from passing HIV to other people through unprotected sex or sharing of needles. Talk with your doctor about safe methods of preventing HIV transmission during sex, such as using a condom and spermicide. Sharing drug or medicine needles is never safe, even for a healthy person.

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