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DRUG DESCRIPTION
Metastron (strontium-89) is a sterile, non-pyrogenic, aqueus solution of St rontium-89 Chloride for intravenous administration. The solution contains no preservative.
Each milliliter contains:
Strontium Water for Injection q.s. to 1 mL
The radioactive concentration is 37 MBq/mL, 1 mCi/mL, and the specific activity is 2.96-6.17 MBq/mg, 80-167 ?Ci/mg at calibration. The pH of the solution is 4 - 7.5.
Physical Characteristics
Strontium-89 decays by beta emission with a physical half-life of 50.5 days. The maximum beta energy is 1.463 MeV (100%). The maximum range of ?- from Strontium-89 in tissue is approximately 8 mm.
Radioactive decay factors to be applied to the stated value for radioactive concentration at calibration, when calculating injection volumes at the time of administration, are given in Table 1.
Table 1: Decay of Strontium-89
Day* | Factor | Day* | Factor |
-24 | 1.39 | +6 | 0.92 |
-22 | 1.35 | +8 | 0.90 |
-20 | 1.32 | +10 | 0.87 |
-18 | 1.28 | +12 | 0.85 |
-16 | 1.25 | +14 | 0.83 |
-14 | 1.21 | +16 | 0.80 |
-12 | 1.18 | +18 | 0.78 |
-10 | 1.15 | +20 | 0.76 |
-8 | 1.12 | +22 | 0.74 |
-6 | 1.09 | +24 | 0.72 |
-4 | 1.06 | +26 | 0.70 |
-2 | 1.03 | +28 | 0.68 |
0=calibration | 1.00 | ||
* Days before (-) or after (+) the calibration date stated on the vial. |