Methergine

DRUG DESCRIPTION

Methergine® (methylergonovine maleate) is a semi-synthetic ergot alkaloid used for the prevention and control of postpartum hemorrhage.

Methergine (methylergonovine maleate) is available in sterile ampuls of 1 mL, containing 0.2 mg methylergonovine maleate for intramuscular or intravenous injection and in tablets for oral ingestion containing 0.2 mg methylergonovine maleate.

Tablets

Active Ingredient: methylergonovine maleate, USP, 0.2 mg.

Inactive Ingredients: acacia, carnauba wax, D&C Red #7, FD&C Blue #1, gelatin special, lactose, maleic acid, mixed parabens, povidone, sodium benzoate, sodium hydroxide, starch, stearic acid, sucrose, talc, and titanium dioxide.

Ampuls, 1 mL, clear, colorless solution.

Active Ingredient: methylergonovine maleate, USP, 0.2 mg.

Inactive Ingredients: maleic acid, 0.10 mg; sodium chloride, 7.0 mg; water for injection, qs to 1 mL.

Chemically, methylergonovine maleate is designated as ergoline-8-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-6-methyl-, [8?(S)]-, (Z)-2-butenedioate (1:1) (salt).

Its structural formula is

Methergine (methylergonovine maleate) structural formula illustration

What are the possible side effects of methylergonovine (Methergine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • increased blood pressure (severe headache, blurred vision);
  • seizure (convulsions);
  • feeling light-headed, fainting;
  • pounding heartbeat;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;...

Read All Potential Side Effects and See Pictures of Methergine »

What are the precautions when taking methylergonovine maleate (Methergine)?

Before taking methylergonovine, tell your doctor or pharmacist if you are allergic to it; or to similar ergot alkaloids (such as ergonovine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, high blood pressure, heart disease (such as venoatrial shunts, mitral valve stenosis), blood vessel disease (such as Raynaud's disease), complications during pregnancy (such as preeclampsia, eclampsia).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can...

Read All Potential Precautions of Methergine »


Methergine Consumer (continued)

SIDE EFFECTS: Headache, nausea, vomiting, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but serious side effects occur: fast/slow heartbeat, shortness of breath, cold hands/feet, pain/redness/swelling of arms or legs.

Seek immediate medical attention if any of these rare but serious side effects occur: chest pain, vision changes, confusion, seizures.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking methylergonovine, tell your doctor or pharmacist if you are allergic to it; or to similar ergot alkaloids (such as ergonovine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, high blood pressure, heart disease (such as venoatrial shunts, mitral valve stenosis), blood vessel disease (such as Raynaud's disease), complications during pregnancy (such as preeclampsia, eclampsia).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication must not be used during pregnancy. It may harm an unborn baby. Consult your doctor for more details.

This medication passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.


Methergine Patient Information Including Side Effects

Brand Names: Methergine

Generic Name: methylergonovine (Pronunciation: meth il er GON o veen)

  • What is methylergonovine (Methergine)?
  • What are the possible side effects of methylergonovine (Methergine)?
  • What is the most important information I should know about methylergonovine (Methergine)?
  • What should I discuss with my health care provider before taking methylergonovine (Methergine)?
  • How should I take methylergonovine (Methergine)?
  • What happens if I miss a dose (Methergine)?
  • What happens if I overdose (Methergine)?
  • What should I avoid while receiving methylergonovine (Methergine)?
  • What other drugs will affect methylergonovine (Methergine)?
  • Where can I get more information?

What is methylergonovine (Methergine)?

Methylergonovine is in a group of drugs called ergot alkaloids. It affects the smooth muscle of a woman's uterus, improving the muscle tone as well as the strength and timing of uterine contractions.

Methylergonovine is used just after a baby is born, to help deliver the placenta (also called the "afterbirth"). It is also used to help control bleeding and other uterine problems after childbirth.

Methylergonovine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of methylergonovine (Methergine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • increased blood pressure (severe headache, blurred vision);
  • seizure (convulsions);
  • feeling light-headed, fainting;
  • pounding heartbeat;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
  • hallucinations.

Other less serious side effects are more likely to occur, such as:

  • nausea, vomiting, diarrhea;
  • leg cramps;
  • dizziness;
  • ringing in your ears;
  • stuffy nose; or
  • unpleasant taste in your mouth.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about methylergonovine (Methergine)?

This medication is to be used only after delivery of your baby.

Methylergonovine may pass into breast milk in small amounts and could affect a nursing baby. In some cases, you will need to use this medication for up to 1 week after your baby is born. Talk with your doctor about whether you should breast-feed during that time. You may need to use a breast pump to establish and maintain your milk flow until your methylergonovine treatment is finished.

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a methylergonovine overdose may include nausea, vomiting, stomach pain, numbness or tingling, muscle twitching, feeling light-headed, fainting, shallow breathing, coldness, or seizure (convulsions).

There may be other drugs that can affect methylergonovine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Grapefruit and grapefruit juice may interact with methylergonovine. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

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