Nafcillin Injection

DRUG DESCRIPTION

Nafcillin Injection, USP is a sterile injectable product containing nafcillin which is added as Nafcillin Sodium, USP, a semisynthetic penicillin derived from the penicillin nucleus, 6aminopenicillanic acid. The chemical name of nafcillin sodium is Monosodium (2S,5R,6R)-6-(2ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]heptane-2-carboxylate monohydrate. It is resistant to inactivation by the enzyme penicillinase (beta-lactamase). The molecular formula of Nafcillin Sodium, USP is C21H21N2NaO5SH2O. The molecular weight is 454.48. The structural formula of nafcillin sodium is as follows:

Nafcillin Structural Formula Illustration

Nafcillin Injection, USP is a frozen, iso-osmotic, sterile, nonpyrogenic premixed 50 mL or 100 mL solution containing 1 g or 2 g of nafcillin, respectively, added as Nafcillin Sodium, USP. Dextrose, USP has been added to the above dosages to adjust osmolality (approximately 1.8 g and 3.6 g as dextrose hydrous to the 1 g and 2 g dosages, respectively). Sodium Citrate Hydrous, USP has been added as a buffer (approximately 90 mg and 180 mg to the 1 g and 2 g dosages, respectively). The pH has been adjusted with hydrochloric acid and may have been adjusted with sodium hydroxide. The pH is 6.5 (6.0 to 8.5). The solution is intended for intravenous use after thawing to room temperature.

This GALAXY container is fabricated from a specially designed multilayer plastic (PL 2040). Solutions are in contact with the polyethylene layer of this container and can leach out certain chemical components of the plastic in very small amounts within the expiration period. The suitability of the plastic has been confirmed in tests in animals according to the USP biological tests for plastic containers, as well as by tissue culture toxicity studies.

What are the possible side effects of nafcillin (Nallpen, Unipen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching; fever, stomach pain, muscle or joint pain; difficulty breathing; swelling of your face, lips, tongue, or throat. A delayed allergic reaction to nafcillin can occur as few as 2 days to as many as 4 weeks after you use the medication.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;
  • fever, chills, body aches, flu symptoms, sores in your mouth and...

Read All Potential Side Effects and See Pictures of Nafcillin Injection

What are the precautions when taking nafcillin sodium (Nafcillin Injection)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients (such as corn for products containing dextrose), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, kidney disease, liver disease.

This medication contains sodium. This could affect you if you are on a salt-restricted diet or if you have a condition which could be worsened with an increase in salt intake (e.g., congestive heart failure). Consult your doctor or pharmacist for more information.

Liver and...

Read All Potential Precautions of Nafcillin Injection


Nafcillin Injection Consumer (continued)

SIDE EFFECTS: If this medication is injected into a muscle, pain at the injection site may occur. If this effect persists or worsens, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: pain/swelling/skin peeling at injection site (if this drug is injected into a vein), joint/muscle pain, dark/cloudy urine, change in the amount of urine, extreme tiredness, easy bruising/bleeding, new signs of infection (e.g., fever, persistent sore throat), seizures, uncontrolled movements, confusion, irregular heartbeat, muscle cramps, weakness.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients (such as corn for products containing dextrose), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, kidney disease, liver disease.

This medication contains sodium. This could affect you if you are on a salt-restricted diet or if you have a condition which could be worsened with an increase in salt intake (e.g., congestive heart failure). Consult your doctor or pharmacist for more information.

Liver and kidney functions decline as you grow older. This medication is removed by the liver. Therefore, elderly people may be at greater risk for side effects while using this drug.

Liver and kidney functions are not fully developed in newborns and infants. This medication is removed by the liver. Therefore, newborns and infants may be a greater risk for side effects while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Consult your doctor before breast-feeding.


Nafcillin Injection Patient Information Including Side Effects

Brand Names: Nallpen, Unipen

Generic Name: nafcillin (injection) (Pronunciation: naf SIL in)

  • What is nafcillin (Nafcillin Injection)?
  • What are the possible side effects of nafcillin (Nafcillin Injection)?
  • What is the most important information I should know about nafcillin (Nafcillin Injection)?
  • What should I discuss with my healthcare provider before using nafcillin (Nafcillin Injection)?
  • How should I use nafcillin (Nafcillin Injection)?
  • What happens if I miss a dose (Nafcillin Injection)?
  • What happens if I overdose (Nafcillin Injection)?
  • What should I avoid while using nafcillin (Nafcillin Injection)?
  • What other drugs will affect nafcillin (Nafcillin Injection)?
  • Where can I get more information?

What is nafcillin (Nafcillin Injection)?

Nafcillin is an antibiotic in the penicillin group of drugs. It fights bacteria in your body.

Nafcillin is used to treat many different types of infections, especially those caused by staphylococcus bacteria ("staph" infections).

Nafcillin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of nafcillin (Nafcillin Injection)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching; fever, stomach pain, muscle or joint pain; difficulty breathing; swelling of your face, lips, tongue, or throat. A delayed allergic reaction to nafcillin can occur as few as 2 days to as many as 4 weeks after you use the medication.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
  • blood in your urine, urinating less than usual or not at all; or
  • pain, swelling, tenderness, or skin changes where the medicine was injected.

Less serious side effects are more likely to occur, such as:

  • nausea, vomiting;
  • vaginal itching or discharge; or
  • black or "hairy" tongue.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about nafcillin (Nafcillin Injection)?

You should not use this medication if you are allergic to nafcillin or to any other penicillin antibiotic, such as amoxicillin (Amoxil), ampicillin (Omnipen, Principen), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using nafcillin, tell your doctor if you are allergic to cephalosporins such as Ceftin, Cefzil, Keflex, Omnicef, and others, or if you have asthma, liver or kidney disease, or a history of any type of allergy.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Nafcillin is usually given for up to 2 days after lab tests show that the infection has cleared.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

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