Norvasc

DRUG DESCRIPTION

NORVASC is the besylate salt of amlodipine, a long-acting calcium channel blocker.

Amlodipine besylate is chemically described as 3-Ethyl-5-methyl (±)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-l,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulphonate. Its empirical formula is C20H25CIN2O5•C6H6O3S, and its structural formula is:

NORVASC®
  (amlodipine besylate) Structural Formula Illustration

Amlodipine besylate is a white crystalline powder with a molecular weight of 567.1. It is slightly soluble in water and sparingly soluble in ethanol. NORVASC (amlodipine besylate) Tablets are formulated as white tablets equivalent to 2.5, 5, and 10 mg of amlodipine for oral administration. In addition to the active ingredient, amlodipine besylate, each tablet contains the following inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, sodium starch glycolate, and magnesium stearate.

What are the possible side effects of amlodipine (Norvasc)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • feeling like you might pass out;
  • swelling in your hands, ankles, or feet;
  • chest pain;
  • slow, fast, or pounding heartbeats;
  • easy bruising or bleeding, unusual weakness;
  • numbness, burning, pain, or tingly feeling; or
  • jaundice...

Read All Potential Side Effects and See Pictures of Norvasc »

What are the precautions when taking amlodipine besylate (Norvasc)?

Before taking amlodipine, tell your doctor or pharmacist if you are allergic to it; or to other dihydropyridine calcium channel blockers (such as nisoldipine, nifedipine) or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain structural heart problem (aortic stenosis), very low blood pressure, liver disease.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or...

Read All Potential Precautions of Norvasc »


Norvasc Consumer (continued)

SIDE EFFECTS: Dizziness, lightheadedness, swelling ankles/feet, flushing, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: fast/irregular/pounding heartbeat, fainting.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking amlodipine, tell your doctor or pharmacist if you are allergic to it; or to other dihydropyridine calcium channel blockers (such as nisoldipine, nifedipine) or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain structural heart problem (aortic stenosis), very low blood pressure, liver disease.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the effects of this drug, especially dizziness.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.


Norvasc Patient Information Including Side Effects

Brand Names: Norvasc

Generic Name: amlodipine (Pronunciation: am LOE di peen)

  • What is amlodipine (Norvasc)?
  • What are the possible side effects of amlodipine (Norvasc)?
  • What is the most important information I should know about amlodipine (Norvasc)?
  • What should I discuss with my healthcare provider before taking amlodipine (Norvasc)?
  • How should I take amlodipine (Norvasc)?
  • What happens if I miss a dose (Norvasc)?
  • What happens if I overdose (Norvasc)?
  • What should I avoid while taking amlodipine (Norvasc)?
  • What other drugs will affect amlodipine (Norvasc)?
  • Where can I get more information?

What is amlodipine (Norvasc)?

Amlodipine is in a group of drugs called calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Amlodipine is used to treat high blood pressure (hypertension) or chest pain (angina).

Amlodipine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of amlodipine (Norvasc)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • feeling like you might pass out;
  • swelling in your hands, ankles, or feet;
  • chest pain;
  • slow, fast, or pounding heartbeats;
  • easy bruising or bleeding, unusual weakness;
  • numbness, burning, pain, or tingly feeling; or
  • jaundice (yellowing of your skin or eyes).

Less serious side effects may include:

  • headache;
  • drowsiness, depression, nervousness;
  • dizziness, spinning sensation;
  • warmth or redness under your skin;
  • nausea, vomiting, stomach pain, loss of appetite;
  • diarrhea, constipation;
  • urinating more than usual;
  • sleep problems (insomnia);
  • strange dreams;
  • mild skin rash or itching;
  • joint or muscle pain;
  • dry mouth, thirst, increased sweating; or
  • weight changes.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about amlodipine (Norvasc)?

Before taking amlodipine, tell your doctor if you have congestive heart failure or liver disease.

Avoid drinking alcohol while taking amlodipine. Alcohol can further lower your blood pressure and may increase some of the side effects of amlodipine.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. You may need to use blood pressure medication for the rest of your life.

Amlodipine is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Tell your doctor about all other heart or blood pressure medications you are taking.

Your chest pain may become worse when you first start taking amlodipine or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

Related Drug Centers
  • Norvasc


Related Drugs Index: