Levophed

DRUG DESCRIPTION

Norepinephrine (sometimes referred to as l-arterenol/Levarterenol or l-norepinephrine) is a sympathomimetic amine which differs from epinephrine by the absence of a methyl group on the nitrogen atom.

Norepinephrine Bitartrate is (-)-?-(aminomethyl)-3,4-dihydroxybenzyl alcohol tartrate (1:1) (salt) monohydrate and has the following structural formula:

LEVOPHED (norepinephrine bitartrate)  structural formula illustration

LEVOPHED (norepinephrine bitartrate) is supplied in sterile aqueous solution in the form of the bitartrate salt to be administered by intravenous infusion following dilution. Norepinephrine is sparingly soluble in water, very slightly soluble in alcohol and ether, and readily soluble in acids. Each mL contains the equivalent of 1 mg base of norepinephrine, sodium chloride for isotonicity, and not more than 0.2 mg of sodium metabisulfite as an antioxidant. It has a pH of 3 to 4.5. The air in the vials has been displaced by nitrogen gas.

What are the possible side effects of norepinephrine (Levophed Bitartrate)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, nausea with vomiting;
  • fast, slow, or uneven heart rate;
  • blue lips or fingernails, mottled skin;
  • urinating less than usual or not at all;
  • ...

Read All Potential Side Effects and See Pictures of Levophed


Levophed Patient Information Including Side Effects

Brand Names: Levophed Bitartrate

Generic Name: norepinephrine (Pronunciation: nor ep i NEF rin)

  • What is norepinephrine (Levophed)?
  • What are the possible side effects of norepinephrine (Levophed)?
  • What is the most important information I should know about norepinephrine (Levophed)?
  • What should I discuss with my health care provider before receiving norepinephrine (Levophed)?
  • How is norepinephrine given (Levophed)?
  • What happens if I miss a dose (Levophed)?
  • What happens if I overdose (Levophed)?
  • What should I avoid while receiving norepinephrine (Levophed)?
  • What other drugs will affect norepinephrine (Levophed)?
  • Where can I get more information?

What is norepinephrine (Levophed)?

Norepinephrine is similar to adrenaline. It works by constricting (narrowing) the blood vessels and increasing blood pressure and blood glucose (sugar) levels.

Norepinephrine is used to treat life-threatening low blood pressure (hypotension) that can occur with certain medical conditions or surgical procedures. This medication is often used during CPR (cardio-pulmonary resuscitation).

Norepinephrine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of norepinephrine (Levophed)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, nausea with vomiting;
  • fast, slow, or uneven heart rate;
  • blue lips or fingernails, mottled skin;
  • urinating less than usual or not at all;
  • irritation of the skin or vein where the medicine is injected;
  • sudden numbness or weakness, especially on one side of the body; or
  • sudden headache, confusion, problems with vision, speech, or balance.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about norepinephrine (Levophed)?

Before receiving norepinephrine, tell your doctor if you have high blood pressure (hypertension), overactive thyroid, asthma, or a sulfite allergy.

Tell your caregivers right away about any serious side effects such as muscle pain or weakness, numb or cold feeling, trouble breathing, urinating less than usual, irritation of the skin or vein where the medicine is injected, uneven heart rate, sudden numbness or weakness, especially on one side of the body, or sudden headache, confusion, or problems with vision, speech, or balance.

Symptoms of a norepinephrine overdose may include slow heart rate, severe headache, blurred vision, trouble concentrating, increased sensitivity to light, stabbing chest or back pain, pale skin, sweating, vomiting, or seizure (convulsions).

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