Namenda

DRUG DESCRIPTION

Namenda® (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula:

Namenda® (memantine hydrochloride) structural formula illustration

The molecular formula is C12H21N•HCl and the molecular weight is 215.76. Memantine HCl occurs as a fine white to off-white powder and is soluble in water. Namenda (memantine hcl) is available as tablets or as an oral solution. Namenda (memantine hcl) is available for oral administration as capsule-shaped, film-coated tablets containing 5 mg and 10 mg of memantine hydrochloride. The tablets also contain the following inactive ingredients: microcrystalline cellulose/colloidal silicon dioxide, talc, croscarmellose sodium, and magnesium stearate. In addition the following inactive ingredients are also present as components of the film coat: hypromellose, titanium dioxide, polyethylene glycol 400, FD&C yellow #6 and FD&C blue #2 (5 mg tablets), and hypromellose, titanium dioxide, macrogol/polyethylene glycol 400 and iron oxide black (10 mg tablets). Namenda oral solution contains memantine hydrochloride in a strength equivalent to 2 mg of memantine hydrochloride in each mL. The oral solution also contains the following inactive ingredients: sorbitol solution (70%), methyl paraben, propylparaben, propylene glycol, glycerin, natural peppermint flavor #104, citric acid, sodium citrate, and purified water.

What are the possible side effects of memantine (Namenda)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using memantine and call your doctor at once if you have any of these serious side effects:

  • cough, chest tightness, fever, trouble breathing;
  • chest pain, fast heart rate;
  • confusion, hallucinations;
  • sudden numbness or weakness, especially on one side of the body;
  • lack of coordination;
  • fainting or seizure...

Read All Potential Side Effects and See Pictures of Namenda »

What are the precautions when taking memantine hcl (Namenda)?

Before taking memantine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, severe liver disease, severe urinary tract infections, recent dietary change (from a high-protein diet to a vegetarian diet).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness...

Read All Potential Precautions of Namenda »


Namenda Consumer (continued)

SIDE EFFECTS: Tiredness, body aches, dizziness, constipation, and headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking memantine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, severe liver disease, severe urinary tract infections, recent dietary change (from a high-protein diet to a vegetarian diet).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Namenda Patient Information Including Side Effects

Brand Names: Namenda

Generic Name: memantine (Pronunciation: meh MAN teen)

  • What is memantine (Namenda)?
  • What are the possible side effects of memantine (Namenda)?
  • What is the most important information I should know about memantine (Namenda)?
  • What should I discuss with my healthcare provider before taking memantine (Namenda)?
  • How should I take memantine (Namenda)?
  • What happens if I miss a dose (Namenda)?
  • What happens if I overdose (Namenda)?
  • What should I avoid while taking memantine (Namenda)?
  • What other drugs will affect memantine (Namenda)?
  • Where can I get more information?

What is memantine (Namenda)?

Memantine reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer's disease.

Memantine is used to treat moderate to severe dementia of the Alzheimer's type.

Memantine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of memantine (Namenda)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using memantine and call your doctor at once if you have any of these serious side effects:

  • cough, chest tightness, fever, trouble breathing;
  • chest pain, fast heart rate;
  • confusion, hallucinations;
  • sudden numbness or weakness, especially on one side of the body;
  • lack of coordination;
  • fainting or seizure (convulsions);
  • urinating less than usual or not at all;
  • pale skin, easy bruising or bleeding, unusual weakness; or
  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

Less serious side effects may include:

  • nausea, vomiting, diarrhea, constipation, loss of appetite;
  • dizziness, tired feeling;
  • weight loss;
  • swelling in your hands or feet;
  • fast heart rate;
  • easy bruising or bleeding, unusual weakness;
  • joint pain;
  • anxiety, aggression;
  • skin rash;
  • redness or swelling of or around your eyes; or
  • urinating more than usual.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about memantine (Namenda)?

Before using memantine, tell your doctor if you are allergic to any drugs, or if you have a seizure disorder, cataracts, liver or kidney disease, or a bladder or kidney infection.

Memantine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

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