Natrecor

DRUG DESCRIPTION

Natrecor® (nesiritide) is a sterile, purified preparation of a new drug class, human B-type natriuretic peptide (hBNP), and is manufactured from E. coli using recombinant DNA technology. Nesiritide has a molecular weight of 3464 g/mol and an empirical formula of C143H244N50O42S4. Nesiritide has the same 32 amino acid sequence as the endogenous peptide, which is produced by the ventricular myocardium.

NATRECOR®
  (nesiritide) amino acid sequence - Illustration

Natrecor (nesiritide) is formulated as the citrate salt of rhBNP, and is provided in a sterile, single-use vial. Each 1.5 mg vial contains a white- to off-white lyophilized powder for intravenous (IV) administration after reconstitution. The quantitative composition of the lyophilized drug per vial is: nesiritide 1.58 mg, mannitol 20.0 mg, citric acid monohydrate 2.1 mg, and sodium citrate dihydrate 2.94 mg.

What are the possible side effects of nesiritide (Natrecor)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • dizziness, chest pain, fast heart rate, or confusion shortly after you receive nesiritide;
  • feeling light-headed, fainting;
  • coughing up blood; or
  • fever, pale skin, easy bruising, unusual weakness.

Less serious side effects may include:

    ...

Read All Potential Side Effects and See Pictures of Natrecor »


Natrecor Patient Information Including Side Effects

Brand Names: Natrecor

Generic Name: nesiritide (Pronunciation: ness EAR a tide )

  • What is nesiritide (Natrecor)?
  • What are the possible side effects of nesiritide (Natrecor)?
  • What is the most important information I should know about nesiritide (Natrecor)?
  • What should I discuss with my healthcare provider before receiving nesiritide (Natrecor)?
  • How is nesiritide given (Natrecor)?
  • What happens if I miss a dose (Natrecor)?
  • What happens if I overdose (Natrecor)?
  • What should I avoid while receiving nesiritide (Natrecor)?
  • What other drugs will affect nesiritide (Natrecor)?
  • Where can I get more information?

What is nesiritide (Natrecor)?

Nesiritide relaxes and dilates blood vessels, lowering blood pressure.

Nesiritide is used to improve breathing in people with congestive heart failure (CHF).

Nesiritide may also be used for other purposes not listed in this medication guide.

What are the possible side effects of nesiritide (Natrecor)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • dizziness, chest pain, fast heart rate, or confusion shortly after you receive nesiritide;
  • feeling light-headed, fainting;
  • coughing up blood; or
  • fever, pale skin, easy bruising, unusual weakness.

Less serious side effects may include:

  • pain, itching, or swelling where the IV needle was placed;
  • numbness or tingling;
  • drowsiness;
  • tremors or shaking;
  • cough;
  • increased sweating;
  • skin rash or itching;
  • leg cramps; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about nesiritide (Natrecor)?

You should not use this medication if you are allergic to nesiritide, or if you have very low blood pressure.

If you have kidney disease, you may need a dose adjustment or special tests to safely receive this medication.

Tell your doctor about any heart problems you currently have or have had in the past. There are certain heart conditions that could make it dangerous for you to receive nesiritide.

Nesiritide is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion. The needle will remain in place while you receive the medication continuously for up to 48 hours.

Your blood pressure will be checked often while you are receiving nesiritide.

Call your doctor at once if you have dizziness, chest pain, fast heart rate, or confusion shortly after you receive nesiritide. Other serious side effects include feeling light-headed, fainting, coughing up blood, fever, pale skin, easy bruising, or unusual weakness.

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