OsmoPrep

DRUG DESCRIPTION

OsmoPrep® (sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrous) (sodium phosphate monobasic monohydrate, USP, and sodium phosphate dibasic anhydrous, USP) is a purgative used to clean the colon prior to colonoscopy. OsmoPrep (sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrous) is manufactured with a highly soluble tablet binder and does not contain microcrystalline cellulose (MCC). OsmoPrep (sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrous) Tablets are oval, white to off-white compressed tablets, debossed with “SLX” on one side of the bisect and “102” on the other side of the bisect. Each OsmoPrep (sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrous) tablet contains 1.102 grams of sodium phosphate monobasic monohydrate, USP and 0.398 grams of sodium phosphate dibasic anhydrous, USP for a total of 1.5 grams of sodium phosphate per tablet. Inert ingredients include polyethylene glycol 8000, NF; and magnesium stearate, NF. OsmoPrep (sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrous) is gluten-free.

The structural and molecular formulae and molecular weights of the active ingredients are shown below:

  • Sodium phosphate monobasic monohydrate, USP

Sodium phosphate monobasic monohydrate Structural Formula Illustration

Molecular Formula: NaH2PO4 •H2O
Molecular Weight: 137.99

  • Sodium phosphate dibasic anhydrous, USP

Molecular Formula: Na2HPO4
Molecular Weight: 141.96

OsmoPrep (sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrous) Tablets are for oral administration only.

What are the possible side effects of sodium biphosphate and sodium phosphate (Fleet Enema, Fleet Enema for Children, OsmoPrep, Visicol)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • rectal bleeding;
  • no bowel movement after use;
  • sores or ulcers around your rectum;
  • seizure (black-out or convulsions);
  • fast, slow, or uneven...

Read All Potential Side Effects and See Pictures of OsmoPrep »

What are the precautions when taking sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrous (OsmoPrep)?

See also How to Use section.

Before taking sodium phosphate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart failure, irregular heartbeat, QT prolongation in the EKG, chest pain, heart attack or heart surgery within the last 3 months), stomach/abdominal problems (such as blockage, severe constipation), gastric bypass/stapling, irritable bowel disease/colitis, low blood minerals, severe loss of body water (dehydration), kidney problems, liver problems (such as...

Read All Potential Precautions of OsmoPrep »


OsmoPrep Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, stomach/abdominal pain or bloating, dizziness, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: black/bloody stools.

Seek immediate medical attention if any of these rare but serious side effects occur: fast/irregular heartbeat, chest pain, fainting, mental mood changes (such as confusion, unusual drowsiness), seizures.

Persistent diarrhea or vomiting may result in a serious loss of body water (dehydration) and minerals. Contact your doctor promptly if you notice any symptoms of dehydration, such as unusual decreased urination, unusual dry mouth/increased thirst, lack of tears, dizziness/lightheadedness, muscle weakness/cramping, or pale/wrinkled skin.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: See also How to Use section.

Before taking sodium phosphate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart failure, irregular heartbeat, QT prolongation in the EKG, chest pain, heart attack or heart surgery within the last 3 months), stomach/abdominal problems (such as blockage, severe constipation), gastric bypass/stapling, irritable bowel disease/colitis, low blood minerals, severe loss of body water (dehydration), kidney problems, liver problems (such as cirrhosis, fluid build-up in the abdomen), salt restricted diet, daily alcohol or sedative use, seizure problem, swallowing problems (such as narrowing of the swallowing tube/ esophagus).

Before having surgery, tell your doctors or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Caution is advised when using this drug in older adults because they may be more sensitive to the effects of the drug, especially kidney problems, dehydration, and irregular heartbeat.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


OsmoPrep Patient Information Including Side Effects

Brand Names: Fleet Enema, Fleet Enema for Children, OsmoPrep, Visicol

Generic Name: sodium biphosphate and sodium phosphate (Pronunciation: SOE dee um bye FOS foe nate and SOE dee um FOS fate)

  • What is sodium biphosphate and sodium phosphate (OsmoPrep)?
  • What are the possible side effects of sodium biphosphate and sodium phosphate (OsmoPrep)?
  • What is the most important information I should know about sodium biphosphate and sodium phosphate (OsmoPrep)?
  • What should I discuss with my healthcare provider before using sodium biphosphate and sodium phosphate (OsmoPrep)?
  • How should I use sodium biphosphate and sodium phosphate (OsmoPrep)?
  • What happens if I miss a dose (OsmoPrep)?
  • What happens if I overdose (OsmoPrep)?
  • What should I avoid while using sodium biphosphate and sodium phosphate (OsmoPrep)?
  • What other drugs will affect sodium biphosphate and sodium phosphate (OsmoPrep)?
  • Where can I get more information?

What is sodium biphosphate and sodium phosphate (OsmoPrep)?

Sodium biphosphate and sodium phosphate are forms of phosphorus, which is a naturally occurring substance that is important in every cell in the body.

Sodium biphosphate and sodium phosphate is used to treat constipation and to clean the bowel before surgery, x-rays, endoscopy, or other intestinal procedures. Sodium biphosphate and sodium phosphate enemas are also used for general care after surgery and to help relieve impacted bowels.

Sodium biphosphate and sodium phosphate may also be used for other purposes not listed in this medication guide.

What are the possible side effects of sodium biphosphate and sodium phosphate (OsmoPrep)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • rectal bleeding;
  • no bowel movement after use;
  • sores or ulcers around your rectum;
  • seizure (black-out or convulsions);
  • fast, slow, or uneven heart rate;
  • urinating less than usual or not at all;
  • drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting; or
  • swelling, weight gain, feeling short of breath.

Less serious side effects may include:

  • bloating, stomach pain;
  • nausea, vomiting, tightness in your throat;
  • dizziness; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about sodium biphosphate and sodium phosphate (OsmoPrep)?

You should not use this medication if you have used it within the past 7 days, or if you have kidney disease, dehydration, or an electrolyte imbalance (such as high or low levels of potassium, sodium, phosphorous, or magnesium in your blood).

If you have any these conditions, you could have dangerous or life-threatening side effects on your kidneys from taking sodium biphosphate and sodium phosphate.

People with eating disorders (such as anorexia or bulimia) should not use this medication without the advice of a doctor.

Before using sodium biphosphate and sodium phosphate, tell your doctor about all of your medical conditions, especially heart disease, liver disease, recent stomach surgery, a bowel perforation or obstruction, colitis or inflammatory bowel disease, seizures, if you are older than 56 years, if you are on a low-salt diet, or if you have recently had a heart attack or recovered from drug or alcohol addiction.

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended.

When using this medication in a child, use only the forms that are specially made for children.

Related Drug Centers
  • OsmoPrep
  • Visicol


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