Optipranolol

DRUG DESCRIPTION

OptiPranolol® (metipranolol ophthalmic solution) 0.3% contains metipranolol, a non-selective beta-adrenergic receptor blocking agent. Metipranolol is a white, odorless, crystalline powder.

The chemical name of metipranolol is (± )-1-(4-Hydroxy-2, 3, 5-trimethylphenoxy)-3-(isopropylamino)-2-propanol-4-acetate.

The chemical structure of metipranolol is:

OptiPranolol® (metipranolol) Structural Formula Illustration

C17H27NO4             Mol. Wt. 309.40

Each mL of OptiPranolol® contains 3 mg of metipranolol. INACTIVES: Povidone, Glycerin, Hydrochloric Acid, Sodium Chloride, Edetate Disodium, and Purified Water. Sodium Hydroxide and/or Hydrochloric Acid may be added to adjust pH. The product is produced at pH 5.0-5.8 and osmolality 265 to 330 mOsmol/kg. PRESERVATIVE ADDED: Benzalkonium Chloride 0.004%.

What are the possible side effects of metipranolol ophthalmic (OptiPranolol)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
  • drainage, crusting, or oozing of your eyes or eyelids;
  • vision changes, increased sensitivity of your eyes to light;
  • bronchospasm...

Read All Potential Side Effects and See Pictures of Optipranolol »

What are the precautions when taking metipranolol ophthalmic solution (Optipranolol)?

Before using metipranolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers (e.g., timolol, levobunolol); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., asthma or a history of asthma, chronic obstructive pulmonary disease-COPD), certain types of heart rhythm problems (e.g., sinus bradycardia, second- or third-degree atrioventricular block), certain serious heart conditions (e.g.,...

Read All Potential Precautions of Optipranolol »


Optipranolol Consumer (continued)

SIDE EFFECTS: Temporary discomfort of the eye, blurred vision, watery eyes, headache, drowsiness, or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: eye pain/swelling/discharge, increased eye sensitivity to light, vision changes, slow/irregular heartbeat, muscle weakness, mental/mood changes, tiredness, swelling of the ankles/feet, sudden/unexplained weight gain.

Seek immediate medical attention if any of these rare but very serious side effects occur: trouble breathing, chest/jaw/left arm pain, weakness on one side of the body, slurred speech, confusion.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using metipranolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers (e.g., timolol, levobunolol); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., asthma or a history of asthma, chronic obstructive pulmonary disease-COPD), certain types of heart rhythm problems (e.g., sinus bradycardia, second- or third-degree atrioventricular block), certain serious heart conditions (e.g., cardiogenic shock, severe heart failure).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e.g., bronchitis, emphysema), diabetes, heart failure (treated, stable type), blood circulation problems (e.g., cerebrovascular insufficiency), overactive thyroid (hyperthyroidism), muscle weakness disorders (e.g., myasthenia gravis).

Before having surgery, tell your doctor or dentist that you are using this medication.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

If you have diabetes, this product may mask the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of a low blood sugar level, such as dizziness/sweating, are unaffected by this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.


Optipranolol Patient Information Including Side Effects

Brand Names: OptiPranolol

Generic Name: metipranolol ophthalmic (Pronunciation: MET i PRAN oh lol)

  • What is metipranolol ophthalmic (Optipranolol)?
  • What are the possible side effects of metipranolol ophthalmic (Optipranolol)?
  • What is the most important information I should know about metipranolol ophthalmic (Optipranolol)?
  • What should I discuss with my healthcare provider before using metipranolol ophthalmic (Optipranolol)?
  • How should I use metipranolol ophthalmic (Optipranolol)?
  • What happens if I miss a dose (Optipranolol)?
  • What happens if I overdose (Optipranolol)?
  • What should I avoid while using metipranolol ophthalmic (Optipranolol)?
  • What other drugs will affect metipranolol ophthalmic (Optipranolol)?
  • Where can I get more information?

What is metipranolol ophthalmic (Optipranolol)?

Metipranolol is a beta-blocker that reduces pressure inside the eye.

Metipranolol ophthalmic (for the eyes) is used to treat open-angle glaucoma and other causes of high pressure inside the eye.

Metipranolol ophthalmic may also be used for other purposes not listed in this medication guide.

What are the possible side effects of metipranolol ophthalmic (Optipranolol)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
  • drainage, crusting, or oozing of your eyes or eyelids;
  • vision changes, increased sensitivity of your eyes to light;
  • bronchospasm (wheezing, chest tightness, trouble breathing);
  • sudden numbness or weakness, headache, confusion, problems with vision, speech, or balance;
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);
  • feeling short of breath, even with mild exertion; or
  • swelling, rapid weight gain.

Less serious side effects may include:

  • mild watering or discomfort of your eyes;
  • blurred vision;
  • mildly swollen or puffy eyes;
  • headache, dizziness, drowsiness;
  • sleep problems (insomnia);
  • muscle weakness; or
  • altered sense of taste or smell.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about metipranolol ophthalmic (Optipranolol)?

Do not use this medication if you are allergic to metipranolol, or if you have asthma, or severe chronic obstructive pulmonary disease (COPD), slow heartbeats, or a heart condition called "AV block."

Before using this medication, tell your doctor if you have breathing problems such as bronchitis or emphysema, a history of heart disease or congestive heart failure, diabetes, history of stroke, blood clot, or circulation problems, a thyroid disorder, or a muscle disorder such as myasthenia gravis.

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Metipranolol ophthalmic is sometimes given together with other eye medications. Do not use any other eye medication unless your doctor has prescribed it for you. If you use another eye medication, use it at least 10 minutes before or after using metipranolol ophthalmic. Do not use the medications at the same time.

Metipranolol ophthalmic can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Do not use this medication while you are wearing contact lenses. Metipranolol ophthalmic may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using metipranolol before putting your contact lenses in.

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