Polymyxin B

DRUG DESCRIPTION

Polymyxin B for Injection (polymyxin b (polymyxin b sulfate) sulfate) is one of a group of basic polypeptide antibiotics derived from B polymyxa (B aerosporous). Polymyxin B (polymyxin b sulfate) sulfate is the sulfate salt of Polymyxins B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillacea).It has a potency of not less than 6000 polymyxin B (polymyxin b sulfate) units per mg, calculated on the anhydrous basis.The structural formulae are:

Polymyxin B Structural Formula Illustration

Each vial contains 500,000 polymyxin B (polymyxin b sulfate) units for parenteral or ophthalmic administration.

Polymyxin B (polymyxin b sulfate) forInjection is in powder form suitable for preparation of sterile solutions for intramuscular, intravenous drip, intrathecal, or ophthalmic use.

In the medical literature, dosages have frequently been given in terms of equivalent weights of pure polymyxin B (polymyxin b sulfate) base.Each milligram of pure polymyxin B (polymyxin b sulfate) base is equivalent to 10,000 units of polymyxin B (polymyxin b sulfate) and each microgram of pure polymyxin B (polymyxin b sulfate) base is equivalent to 10 units of polymyxin B.

Aqueous solutions of polymyxin B (polymyxin b sulfate) sulfate may be stored up to 12 months without significant loss of potency if kept under refrigeration.In the interest of safety, solutions for parenteral use should be stored under refrigeration and any unused portion should be discarded after 72 hours. Polymyxin B (polymyxin b sulfate) sulfate should not be stored in alkaline solutions since they are less stable.



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