Perphenazine Tablets

DRUG DESCRIPTION

Perphenazine (perphenazine) (4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol), a piperazinyl phenothiazine, having the chemical formula, C21H26CIN3OS. It is available as oral tablets containing 2 mg, 4 mg, 8 mg, and 16 mg of perphenazine (perphenazine) .

Inactive ingredients: lactose (monohydrate), hydroxypropyl cellulose, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, starch (corn), titanium dioxide, and polysorbate 80. Its structural formula is:

Perphenazine Structural Formula Illustration

Actions

Perphenazine (perphenazine) has actions at all levels of the central nervous system, particularly the hypothalamus. However, the site and mechanism of action of therapeutic effect are not known.

What are the possible side effects of perphenazine (Trilafon)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using perphenazine and call your doctor at once if you have a serious side effect such as:

  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • confusion,...

Read All Potential Side Effects and See Pictures of Perphenazine Tablets

What are the precautions when taking perphenazine (Perphenazine Tablets)?

Before taking perphenazine, tell your doctor or pharmacist if you are allergic to it, or to other phenothiazines (e.g., chlorpromazine, fluphenazine), or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: decreased bone marrow function, serious head injury, severe liver problems, severe nervous system problem (e.g., coma, drug/alcohol overdose, shock), Parkinson's disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of alcohol/substance...

Read All Potential Precautions of Perphenazine Tablets


Perphenazine Tablets Consumer (continued)

SIDE EFFECTS: Drowsiness, constipation, dry mouth, dizziness, blurred vision, tiredness, or unexplained weight gain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Some people using this medication do not have serious side effects.

This drug may cause muscle/nervous system problems (extrapyramidal symptoms-EPS). Your doctor may prescribe another medication to decrease these side effects. Therefore, tell your doctor immediately if you notice any of the following side effects: increased anxiety, drooling/trouble swallowing, restlessness/constant need to move, shaking (tremor), shuffling walk, stiff muscles.

Tell your doctor immediately if any of these unlikely but serious side effects occur: difficulty urinating.

This medication may cause a condition known as tardive dyskinesia. In some cases, this condition may be permanent. Tell your doctor immediately if you develop any involuntary/repetitive muscle movements such as lip smacking/puckering, tongue thrusting, chewing, or finger/toe movements.

In rare cases, perphenazine may increase your level of a certain chemical made by the body (prolactin). For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor immediately.

Tell your doctor immediately if any of these rare but very serious side effects occur: easy bruising/bleeding, slow/fast/irregular heartbeat, signs of infection (e.g., sore throat), severe muscle spasm/cramping (e.g., twisting neck, arching back, eyes rolling up), persistent nausea, seizures, stomach/abdominal pain, dark urine, yellowing eyes/skin.

This drug may rarely cause a serious (sometimes fatal) nervous system problem (neuroleptic malignant syndrome-NMS). Seek immediate medical attention if you notice any of the following rare but very serious side effects: fever, stiff muscles, increased sweating, fast heartbeat, mental/mood changes, change in the amount of urine.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking perphenazine, tell your doctor or pharmacist if you are allergic to it, or to other phenothiazines (e.g., chlorpromazine, fluphenazine), or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: decreased bone marrow function, serious head injury, severe liver problems, severe nervous system problem (e.g., coma, drug/alcohol overdose, shock), Parkinson's disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of alcohol/substance abuse, low blood pressure, breathing problems (e.g., asthma, emphysema), breast cancer, fast/slow/irregular heartbeat, heart valve problems, a certain adrenal gland tumor (pheochromocytoma), restless legs syndrome, seizure disorder, a certain severe reaction to other medications (neuroleptic malignant syndrome), difficulty urinating (e.g., due to prostate problems).

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.

To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Caution is advised during hot weather because perphenazine can reduce sweating, increasing your risk for a severe reaction to too much heat (heatstroke). Drink plenty of fluids. Avoid strenuous exercise in hot weather. If you become overheated, promptly seek cooler shelter and/or stop exercising. Seek immediate medical attention if your body temperature is above normal or if you have mental/mood changes, headache, or dizziness.

Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially dizziness and muscle/nervous system problems such as extrapyramidal symptoms and tardive dyskinesia (see Side Effects).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Do not stop taking this medication unless directed by your doctor. Babies born to mothers who have used this drug during the last 3 months of pregnancy may infrequently develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn anytime during their first month, tell the doctor right away.

Perphenazine passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.


Perphenazine Tablets Patient Information Including Side Effects

Brand Names: Trilafon

Generic Name: perphenazine (Pronunciation: per FEN a zeen)

  • What is perphenazine (Perphenazine Tablets)?
  • What are the possible side effects of perphenazine (Perphenazine Tablets)?
  • What is the most important information I should know about perphenazine (Perphenazine Tablets)?
  • What should I discuss with my healthcare provider before taking perphenazine (Perphenazine Tablets)?
  • How should I take perphenazine (Perphenazine Tablets)?
  • What happens if I miss a dose (Perphenazine Tablets)?
  • What happens if I overdose (Perphenazine Tablets)?
  • What should I avoid while taking perphenazine (Perphenazine Tablets)?
  • What other drugs will affect perphenazine (Perphenazine Tablets)?
  • Where can I get more information?

What is perphenazine (Perphenazine Tablets)?

Perphenazine is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Perphenazine is used to treat psychotic disorders such as schizophrenia. It is also used to control severe nausea and vomiting.

Perphenazine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of perphenazine (Perphenazine Tablets)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using perphenazine and call your doctor at once if you have a serious side effect such as:

  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • confusion, unusual thoughts or behavior;
  • feeling like you might pass out;
  • seizure (convulsions);
  • decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;
  • nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);
  • high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;
  • pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;
  • urinating less than usual or not at all;
  • joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious side effects may include:

  • dizziness, drowsiness, anxiety;
  • blurred vision, headache;
  • sleep problems (insomnia), strange dreams;
  • constipation;
  • dry mouth or stuffy nose;
  • breast swelling or discharge;
  • changes in your menstrual periods;
  • weight gain, swelling in your hands or feet;
  • impotence, trouble having an orgasm; or
  • mild itching or skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about perphenazine (Perphenazine Tablets)?

Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

Perphenazine is not for use in psychotic conditions related to dementia. Perphenazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Do not use perphenazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder, or if you are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to perphenazine or other phenothiazines.

Before you take perphenazine, tell your doctor if you have severe depression, heart disease or high blood pressure, liver or kidney disease, severe asthma or breathing problems, history of seizures, Parkinson's disease, past or present breast cancer, adrenal gland tumor, enlarged prostate or urination problems, glaucoma, low levels of calcium in your blood, or if you have ever had serious side effects while using chlorpromazine or similar medicines.

Before taking perphenazine, tell your doctor about all other medications you use.

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