Pletal

DRUG DESCRIPTION

Pletal (cilostazol) is a quinolinone derivative that inhibits cellular phosphodiesterase (more specific for phosphodiesterase III). The empirical formula of cilostazol is C20H27N5O2, and its molecular weight is 369.46. Cilostazol is 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, CAS-73963-72-1. The structural formula is:

PLETAL (PLAY-tal)  Structural Formula Illustration

Cilostazol occurs as white to off-white crystals or as a crystalline powder that is slightly soluble in methanol and ethanol, and is practically insoluble in water, 0.1 N HCl, and 0.1 N NaOH.

Pletal (cilostazol) tablets for oral administration are available in 50 mg triangular and 100 mg round, white debossed tablets. Each tablet, in addition to the active ingredient, contains the following inactive ingredients: carboxymethylcellulose calcium, corn starch, hydroxypropyl methylcellulose 2910, magnesium stearate, and microcrystalline cellulose.

What are the possible side effects of cilostazol (Pletal)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe headache;
  • bloody urine, painful urination;
  • fever, chills, body aches, flu symptoms;
  • chest pain;
  • feeling short of breath, even with mild exertion; or
  • swelling of your ankles or feet.

Less serious side effects may...

Read All Potential Side Effects and See Pictures of Pletal

What are the precautions when taking cilostazol (Pletal)?

Before taking cilostazol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding disorders (such as bleeding ulcers, bleeding in the eye/brain), congestive heart failure, other heart disease (such as heart attack, chest pain, fast/irregular heartbeat), stroke, kidney disease, liver disease, blood disorders (such as hemophilia, low platelet counts).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such...

Read All Potential Precautions of Pletal


Pletal Consumer (continued)

SIDE EFFECTS: Headache, diarrhea, runny nose, and dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these serious side effects occur: fast/pounding/irregular heartbeat, swelling of the hands/feet.

Tell your doctor immediately if any of these unlikely but serious side effects occur: easy bruising/bleeding, black or bloody stools, vomit that looks like coffee grounds, signs of infection (such as fever, persistent sore throat).

Get medical help right away if any of these rare but serious side effects occur: chest/jaw/left arm pain, fainting, vision changes, weakness on one side of the body, slurred speech, confusion.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking cilostazol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding disorders (such as bleeding ulcers, bleeding in the eye/brain), congestive heart failure, other heart disease (such as heart attack, chest pain, fast/irregular heartbeat), stroke, kidney disease, liver disease, blood disorders (such as hemophilia, low platelet counts).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.


Pletal Patient Information Including Side Effects

Brand Names: Pletal

Generic Name: cilostazol (Pronunciation: sil OS tah zol)

  • What is cilostazol (Pletal)?
  • What are the possible side effects of cilostazol (Pletal)?
  • What is the most important information I should know about cilostazol (Pletal)?
  • What should I discuss with my healthcare provider before taking cilostazol (Pletal)?
  • How should I take cilostazol (Pletal)?
  • What happens if I miss a dose (Pletal)?
  • What happens if I overdose (Pletal)?
  • What should I avoid while taking cilostazol (Pletal)?
  • What other drugs will affect cilostazol (Pletal)?
  • Where can I get more information?

What is cilostazol (Pletal)?

Cilostazol widens arteries that supply blood to the legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting.

Cilostazol is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain.

Cilostazol may also be used for other purposes not listed in this medication guide.

What are the possible side effects of cilostazol (Pletal)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe headache;
  • bloody urine, painful urination;
  • fever, chills, body aches, flu symptoms;
  • chest pain;
  • feeling short of breath, even with mild exertion; or
  • swelling of your ankles or feet.

Less serious side effects may include:

  • fast or pounding heartbeats;
  • diarrhea, vomiting;
  • weakness, dizziness;
  • leg cramps;
  • numbness or tingling;
  • joint pain; or
  • cough, runny or stuffy nose.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about cilostazol (Pletal)?

Do not take cilostazol if you have congestive heart failure. Cilostazol can make this condition worse.

It may take up to 12 weeks of using cilostazol before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment.

Grapefruit and grapefruit juice may interact with cilostazol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Take cilostazol on an empty stomach, at least 30 minutes before or 2 hours after food.

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