Protopam

DRUG DESCRIPTION

Chemical name: 2-formyl-1-methylpyridinium chloride oxime. Available in the United States as PROTOPAM Chloride for Injection (PROTOPAM), pralidoxime chloride is frequently referred to as 2-PAM Chloride.

Structural formula:

PROTOPAM Chloride (pralidoxime chloride) Structural Formula Illustration

C7H9CIN2O M.W. 172.61

Pralidoxime chloride occurs as an odorless, white, nonhygroscopic, crystalline powder which is soluble in water. Stable in air, it melts between 215 and 225 C, with decomposition.

The specific activity of the drug resides in the 2-formyl-1-methylpyridinium ion and is independent of the particular salt employed. The chloride is preferred because of physiologic compatibility, excellent water solubility at all temperatures, and high potency per gram, due to its low molecular weight.

Pralidoxime chloride is a cholinesterase reactivator.

PROTOPAM (pralidoxime chloride) for intravenous injection or infusion is prepared by cryo-desiccation. Each vial contains 1000 mg of sterile pralidoxime chloride, and sodium hydroxide to adjust pH, to be reconstituted with 20 mL of Sterile Water for Injection, USP. The pH of the reconstituted solution is 3.5 to 4.5. Intramuscular or subcutaneous injection may be used when intravenous injection is not feasible.

What are the possible side effects of pralidoxime injection (Protopam Chloride)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • fast heart rate;
  • rapid breathing;
  • increased muscle stiffness;
  • a choking feeling;

Less serious side effects may include:

  • pain where the medicine was injected;
  • blurred vision;
  • feeling...

Read All Potential Side Effects and See Pictures of Protopam


Protopam Patient Information Including Side Effects

Brand Names: Protopam Chloride

Generic Name: pralidoxime injection (Pronunciation: PRAL i DOX eem)

  • What is pralidoxime injection (Protopam)?
  • What are the possible side effects of pralidoxime injection (Protopam)?
  • What is the most important information I should know about pralidoxime injection (Protopam)?
  • What should I discuss with my health care provider before receiving pralidoxime injection (Protopam)?
  • How is pralidoxime injection given (Protopam)?
  • What happens if I miss a dose (Protopam)?
  • What happens if I overdose (Protopam)?
  • What should I avoid after receiving pralidoxime injection (Protopam)?
  • What other drugs will affect pralidoxime injection (Protopam)?
  • Where can I get more information?

What is pralidoxime injection (Protopam)?

Pralidoxime reverses muscle weakness or paralysis caused by a poison or certain drug overdose.

Pralidoxime is used as an antidote to treat poisoning by a pesticide or by a drug used to treat a muscle disorder.

This medication is not effective as an antidote for all types of pesticide poisonings.

Pralidoxime may also be used for purposes not listed in this medication guide.

What are the possible side effects of pralidoxime injection (Protopam)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • fast heart rate;
  • rapid breathing;
  • increased muscle stiffness;
  • a choking feeling;

Less serious side effects may include:

  • pain where the medicine was injected;
  • blurred vision;
  • feeling dizzy or drowsy;
  • headache; or
  • nausea.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pralidoxime injection (Protopam)?

In an emergency situation, it may not be possible before you are treated with pralidoxime to tell your caregivers about any health conditions you have or if you are pregnant or breast-feeding. However, make sure any doctor caring for your pregnancy or your baby knows that you have received this medication.

Tell your caregivers at once if you have a fast heart rate, rapid breathing, increased muscle stiffness, or a choking feeling.

Do not use any of the following drugs while you are receiving pralidoxime: morphine (Kadian, MS Contin, Oramorph, and others), aminophylline (Truphylline), or theophylline (Elixophyllin, Respbid, Slo-Bid, Theobid, Theo-Dur, and others).

Follow your doctor's instructions about any restrictions on food, beverages, or activity after you receive pralidoxime.

To be sure this medication is helping your condition, your blood will need to be tested. You may also need follow-up appointments after you are released from emergency care. Do not miss any scheduled appointments.

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