Probenecid and Colchicine

DRUG DESCRIPTION

Probenecid and colchicine contains probenecid, which is a uricosuric agent, and colchicine, which has antigout activity, the mechanism of which is unknown.

Probenecid is the generic name for 4-[(dipropylamino) sulfonyl] benzoic acid. The structural formula is represented below:

Probenecid and Colchicine Tablets USP Structural Formula Illustration

C13H19NO4S....................M.W. 285.36

Probenecid is a white or nearly white, fine, crystalline powder. It is soluble in dilute alkali, in alcohol, in chloroform, and in acetone; it is practically insoluble in water and in dilute acids.

Colchicine is an alkaloid obtained from various species of Colchicum. The chemical name for colchicine is (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[?]heptalen-7-yl) acetamide. The structural formula is represented below:


C22H25NO6.................................M.W. 399.44

Colchicine consists of pale yellow scales or powder; it darkens on exposure to light. Colchicine is soluble in water, freely soluble in alcohol and in chloroform, and slightly soluble in ether. Each tablet for oral administration contains 500 mg of probenecid and 0.5 mg of colchicine.

Each tablet also contains the following inactive ingredients: colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate and sodium starch glycolate.

What are the possible side effects of colchicine and probenecid ()?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have any of these serious side effects:

  • painful urination, severe pain in your lower back or side;
  • easy bruising or bleeding, unusual weakness; or
  • severe diarrhea, nausea, vomiting, or stomach pain.

Continue using colchicine and probenecid and talk...

Read All Potential Side Effects and See Pictures of Probenecid and Colchicine

What are the precautions when taking probenecid and colchicine (Probenecid and Colchicine)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other calcium channel blockers (e.g., amlodipine, felodipine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart diseases (e.g., congestive heart failure, aortic stenosis), liver problems, esophagus/stomach/intestine problems (e.g., narrowing/stricture, motility disorders, or obstruction), kidney problems, a certain metabolic disorder (porphyria).

Before having surgery, tell your doctor or dentist that you are taking this medication.

This drug...

Read All Potential Precautions of Probenecid and Colchicine


Probenecid and Colchicine Consumer (continued)

SIDE EFFECTS: Headache, dizziness, nausea, flushing, constipation, leg/muscle cramps, or sexual problems may occur. To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

An empty tablet shell may appear in your stool. This is harmless since your body has already absorbed the medication.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: swelling of the ankles/feet, shortness of breath, unusual weakness/tiredness.

Tell your doctor immediately if any of these rare but very serious side effects occur: fast/slow/irregular heartbeat, fainting, mental/mood changes, swollen/tender gums, vision changes.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other calcium channel blockers (e.g., amlodipine, felodipine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart diseases (e.g., congestive heart failure, aortic stenosis), liver problems, esophagus/stomach/intestine problems (e.g., narrowing/stricture, motility disorders, or obstruction), kidney problems, a certain metabolic disorder (porphyria).

Before having surgery, tell your doctor or dentist that you are taking this medication.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Nifedipine passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.


Probenecid and Colchicine Patient Information Including Side Effects

Brand Names:

Generic Name: colchicine and probenecid (Pronunciation: KOL chi seen and pro BEN e sid)

  • What is colchicine and probenecid ?
  • What are the possible side effects of colchicine and probenecid ?
  • What is the most important information I should know about colchicine and probenecid ?
  • What should I discuss with my health care provider before taking colchicine and probenecid ?
  • How should I take colchicine and probenecid ?
  • What happens if I miss a dose ?
  • What happens if I overdose ?
  • What should I avoid while taking colchicine and probenecid ?
  • What other drugs will affect colchicine and probenecid ?
  • Where can I get more information?

What is colchicine and probenecid ?

Colchicine alters the way your body responds to uric acid crystals. Too much uric acid in the body is what leads to the symptoms of gout (swelling and pain).

Probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine.

The colchicine and probenecid combination is used to prevent gout attacks. This medication will not cure gout and it will not stop a gout attack that has already started.

Colchicine and probenecid may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of colchicine and probenecid ?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have any of these serious side effects:

  • painful urination, severe pain in your lower back or side;
  • easy bruising or bleeding, unusual weakness; or
  • severe diarrhea, nausea, vomiting, or stomach pain.

Continue using colchicine and probenecid and talk with your doctor if you have any of these less serious side effects:

  • mild nausea, vomiting, stomach pain, loss of appetite;
  • headache;
  • dizziness;
  • hair loss; or
  • warmth or tingly feeling.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about colchicine and probenecid ?

This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Keep taking colchicine and probenecid on a regular schedule, even if you take other gout medications.

You may not notice the effects of this medicine right away. Your gout attacks should occur less often as you continue to take colchicine and probenecid. Taking the medicine for several months may cause the attacks to stop altogether. It is important to use the medication regularly to get the most benefit. Tell your doctor if your symptoms do not improve.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using colchicine and probenecid.

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