Mozobil

DRUG DESCRIPTION

Mozobil (plerixafor injection) is a sterile, preservative-free, clear, colorless to pale yellow, isotonic solution for subcutaneous injection. Each mL of the sterile solution contains 20 mg of plerixafor. Each single-use vial is filled to deliver 1.2 mL of the sterile solution that contains 24 mg of plerixafor and 5.9 mg of sodium chloride in Water for Injection adjusted to a pH of 6.0 to 7.5 with hydrochloric acid and with sodium hydroxide, if required.

Plerixafor is a hematopoietic stem cell mobilizer with a chemical name 1, l'-[l,4-phenylenebis (methylene)]-bis-l,4,8,11- tetraazacyclotetradecane. It has the molecular formula C28H54N8. The molecular weight of plerixafor is 502.79 g/mol. The structural formula is provided in Figure 1.

Figure 1: Structural Formula

Mozobil (plerixafor) Structural Formula Illustration

Plerixafor is a white to off-white crystalline solid. It is hygroscopic. Plerixafor has a typical melting point of 131.5 C. The partition coefficient of plerixafor between 1 -octanol and pH 7 aqueous buffer is < 0.1.

What are the possible side effects of plerixafor (Mozobil)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • easy bruising or bleeding, unusual weakness;
  • feeling like you might pass out; or
  • pain in your upper stomach, spreading to your shoulder or back.

Less serious side effects may include:

  • nausea, vomiting;
  • diarrhea,...

Read All Potential Side Effects and See Pictures of Mozobil


Mozobil Patient Information Including Side Effects

Brand Names: Mozobil

Generic Name: plerixafor (Pronunciation: pler IX a fore)

  • What is plerixafor (Mozobil)?
  • What are the possible side effects of plerixafor (Mozobil)?
  • What is the most important information I should know about plerixafor (Mozobil)?
  • What should I discuss with my health care provider before taking plerixafor (Mozobil)?
  • How is plerixafor given (Mozobil)?
  • What happens if I miss a dose (Mozobil)?
  • What happens if I overdose (Mozobil)?
  • What should I avoid while taking plerixafor (Mozobil)?
  • What other drugs will affect plerixafor (Mozobil)?
  • Where can I get more information?

What is plerixafor (Mozobil)?

Plerixafor works by helping your bone marrow release stem cells into your bloodstream so they can be collected and transplanted back into the body.

Plerixafor is used in people with non-Hodgkin's lymphoma or multiple myeloma.

Plerixafor may also be used for other purposes not listed in this medication guide.

What are the possible side effects of plerixafor (Mozobil)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • easy bruising or bleeding, unusual weakness;
  • feeling like you might pass out; or
  • pain in your upper stomach, spreading to your shoulder or back.

Less serious side effects may include:

  • nausea, vomiting;
  • diarrhea, constipation;
  • dry mouth, numbness in or around your mouth;
  • upset stomach, bloating, gas;
  • tired feeling, trouble sleeping;
  • headache, dizziness;
  • joint or muscle pain;
  • increased sweating; or
  • itching, rash, or other irritation where the medication was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about plerixafor (Mozobil)?

Do not receive plerixafor without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

You should not receive this medication if you are allergic to plerixafor, or if you have leukemia.

Before you take plerixafor, tell your doctor if you have kidney disease.

Plerixafor is given as an injection in a hospital or clinic setting.

Before receiving plerixafor, you will be given another medication that will help your bone marrow produce stem cells and certain white blood cells that help support your immune system.

To be sure this medication is not causing harmful effects, your blood will need to be tested often.

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