Promethazine HCl Suppositories

DRUG DESCRIPTION

Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with ascorbyl palmitate, silicon dioxide, white wax, and cocoa butter. Promethazine hydrochloride suppositories are for rectal administration only.

Promethazine HCl is a racemic compound; the empirical formula is C17H20N2S•HCl and its molecular weight is 320.88.

Promethazine HCl, a phenothiazine derivative, is designated chemically as 10H-Phenothiazine-10-ethanamine, N,N,?-trimethyl-, monohydrochloride, (±)- with the following structural formula:

Promethazine Hydrochloride Structural Formula Illustration

Promethazine HCl occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. It is freely soluble in water and soluble in alcohol.

What are the possible side effects of rectal promethazine (Phenadoz, Promethegan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using promethazine and call your doctor at once if you have any of these serious side effects:

  • twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or...

Read All Potential Side Effects and See Pictures of Promethazine HCl Suppositories »


Promethazine HCl Suppositories Patient Information Including Side Effects

Brand Names: Phenadoz, Promethegan

Generic Name: promethazine (rectal) (Pronunciation: pro METH a zeen)

  • What is rectal promethazine (Promethazine HCl Suppositories)?
  • What are the possible side effects of rectal promethazine (Promethazine HCl Suppositories)?
  • What is the most important information I should know about rectal promethazine (Promethazine HCl Suppositories)?
  • What should I discuss with my health care provider before using rectal promethazine (Promethazine HCl Suppositories)?
  • How should I use rectal promethazine (Promethazine HCl Suppositories)?
  • What happens if I miss a dose (Promethazine HCl Suppositories)?
  • What happens if I overdose (Promethazine HCl Suppositories)?
  • What should I avoid while using rectal promethazine (Promethazine HCl Suppositories)?
  • What other drugs will affect rectal promethazine (Promethazine HCl Suppositories)?
  • Where can I get more information?

What is rectal promethazine (Promethazine HCl Suppositories)?

Promethazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain. Promethazine also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.

Promethazine is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

Promethazine also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.

Promethazine is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections.

Promethazine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of rectal promethazine (Promethazine HCl Suppositories)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using promethazine and call your doctor at once if you have any of these serious side effects:

  • twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;
  • feeling like you might pass out;
  • seizure (convulsions);
  • shallow breathing, weak pulse;
  • pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;
  • decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;
  • hallucinations, agitation;
  • nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);
  • urinating less than usual or not at all;
  • joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious side effects may include:

  • dizziness, drowsiness, sleepiness, or feeling restless;
  • blurred vision, dry mouth, stuffy nose;
  • ringing in your ears;
  • weight gain, swelling in your hands or feet;
  • impotence, trouble having an orgasm; or
  • constipation.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about rectal promethazine (Promethazine HCl Suppositories)?

Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

Promethazine should not be used in a child younger than 2 years old. Promethazine can cause severe breathing problems or death in a child younger than 2. Carefully follow your doctor's instructions when giving this medicine to a child of any age.

Do not take promethazine rectal by mouth. It is for use only in your rectum.

Promethazine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol, which can increase some of the side effects of promethazine.

There are many other medicines that can interact with promethazine. Tell your doctor about all the prescription and over-the-counter medications you use.

Related Drug Centers
  • Promethazine HCl Suppositories


Related Drugs Index: