Papaverine

DRUG DESCRIPTION

Papaverine hydrochloride, C20H21NO4•HCl, is a white, crystalline powder, odorless, with a slight bitter taste and is soluble in water.

Each capsule contains: papaverine hydrochloride USP 150 mg.

Chemically, it is Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride. It has a molecular weight of 375.85. It has the following structural formula:

Papaverine Hydrochloride Structural Formula Illustration

Manufactured in a special base which is designed for prolonged release. Each capsule also contains the following inactive ingredients: FD&C blue No. 1, FD&C red No. 40, gelatin, pharmaceutical glaze, povidone, silicon dioxide, sodium lauryl sulfate, corn starch, sucrose and talc.

What are the possible side effects of papaverine (Papacon, Para-Time S. R., Pavabid Plateau, Pavacot, Pavagen)?

Stop taking papaverine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Stop taking papaverine and contact your doctor if your skin or eyes develop a yellow tint.

Other, less serious side effects may be more likely to occur. Continue to take papaverine and talk to your doctor if you experience

  • nausea, decreased appetite, diarrhea, or...

Read All Potential Side Effects and See Pictures of Papaverine »

What are the precautions when taking papaverine (Papaverine)?

Before taking papaverine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain heart problem (atrioventricular block), Parkinson's disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, irregular heartbeat, liver problems.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such...

Read All Potential Precautions of Papaverine »


Papaverine Consumer (continued)

SIDE EFFECTS: Dizziness, drowsiness, warm/red face (flushing), sweating, headache, or nausea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. To lower your risk of serious side effects, follow your doctor's directions and keep all medical/lab appointments.

Tell your doctor immediately if any of these unlikely but serious side effects occur: fast/irregular heartbeat, vision changes (e.g., blurred/double vision).

Papaverine has rarely caused very serious liver disease. Tell your doctor immediately if you develop symptoms of liver disease, including persistent nausea, stomach/abdominal pain, dark urine, yellowing eyes/skin.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking papaverine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain heart problem (atrioventricular block), Parkinson's disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, irregular heartbeat, liver problems.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Papaverine Patient Information Including Side Effects

Brand Names: Papacon, Para-Time S. R., Pavabid Plateau, Pavacot, Pavagen

Generic Name: papaverine (Pronunciation: pa PAV uh reen)

  • What is papaverine (Papaverine)?
  • What are the possible side effects of papaverine (Papaverine)?
  • What is the most important information I should know about papaverine (Papaverine)?
  • Who should not take papaverine (Papaverine)?
  • How should I take papaverine (Papaverine)?
  • What happens if I miss a dose (Papaverine)?
  • What happens if I overdose (Papaverine)?
  • What should I avoid while taking papaverine (Papaverine)?
  • What other drugs will affect papaverine (Papaverine)?
  • Where can I get more information?

What is papaverine (Papaverine)?

Papaverine is in a class of drugs called vasodilators. Papaverine relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily. These actions may help to increase the amount of oxygen-rich blood in your brain, heart, and muscles.

Papaverine may also be useful in treating conditions involving spasms of the intestines and urinary tract.

Papaverine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of papaverine (Papaverine)?

Stop taking papaverine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Stop taking papaverine and contact your doctor if your skin or eyes develop a yellow tint.

Other, less serious side effects may be more likely to occur. Continue to take papaverine and talk to your doctor if you experience

  • nausea, decreased appetite, diarrhea, or constipation;
  • dizziness or drowsiness;
  • headache;
  • sweating and flushing;
  • a rash; or
  • irregular heartbeats.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about papaverine (Papaverine)?

Use caution when driving, operating machinery, or performing other hazardous activities. Papaverine may cause dizziness. If you experience dizziness, avoid these activities.

If you experience dizziness, rise slowly from a sitting or lying position to avoid falling.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking papaverine.

Notify your doctor if you experience especially bothersome sweating, rash, flushing, headache, tiredness, yellowing of your skin, nausea, decreased appetite, diarrhea, or constipation.

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