Provocholine

DRUG DESCRIPTION

Provocholine® (methacholine chloride powder for inhalation) is a parasympathomimetic (cholinergic) bronchoconstrictor agent to be administered in solutiOn only, by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine chloride powder which is to be reconstituted with 0.9% sodium chloride injection or 0.9% sodium chloride injection containing 0.4% phenol (pH 7.0). See DOSAGE AND ADMINISTRATION for dilution procedures, concentrations and schedule of administration.

Chemically, methacholine chloride (the active ingredient) is 1-propanaminium, 2-(acetyloxy)?­N,N,N, - trimethyl,-chloride. It is a white to practically white deliquescent compound, soluble in water. Methacholine chloride has an empirical formula of C8H18CINO2, a calculated molecular weight of 195.69, and the following structural formula:

PROVOCHOLINE® (METHACHOLINE CHLORIDE) Structural Formula Illustration

What are the precautions when taking methacholine chloride (Provocholine)?

Before using methacholine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: asthma.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, heart disease, thyroid disease, trouble urinating (urinary obstruction), stomach ulcers, seasonal allergies/"hay fever" (allergic rhinitis), history of being exposed to air pollutants, recent/current flu, other lung disease (e.g., cystic fibrosis,...

Read All Potential Precautions of Provocholine »

What are the precautions when taking methacholine chloride (Provocholine)?

Before using methacholine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: asthma.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, heart disease, thyroid disease, trouble urinating (urinary obstruction), stomach ulcers, seasonal allergies/"hay fever" (allergic rhinitis), history of being exposed to air pollutants, recent/current flu, other lung disease (e.g., cystic fibrosis,...

Read All Potential Precautions of Provocholine »

What are the precautions when taking methacholine chloride (Provocholine)?

Before using methacholine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: asthma.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, heart disease, thyroid disease, trouble urinating (urinary obstruction), stomach ulcers, seasonal allergies/"hay fever" (allergic rhinitis), history of being exposed to air pollutants, recent/current flu, other lung disease (e.g., cystic fibrosis,...

Read All Potential Precautions of Provocholine »


Provocholine Consumer (continued)

SIDE EFFECTS: Headache, sore throat, lightheadedness, nausea, vomiting, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these serious side effects occur: trouble breathing, cough, wheezing, chest pain/tightness, irregular heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using methacholine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: asthma.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, heart disease, thyroid disease, trouble urinating (urinary obstruction), stomach ulcers, seasonal allergies/"hay fever" (allergic rhinitis), history of being exposed to air pollutants, recent/current flu, other lung disease (e.g., cystic fibrosis, chronic obstructive pulmonary disease-COPD).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.



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