Pyrazinamide

DRUG DESCRIPTION

Pyrazinamide, the pyrazine analogue of nicotinamide, is an anti-tuberculous agent. It is a white crystalline powder, stable at room temperature, and sparingly soluble in water. Pyrazinamide has the following structural formula:

C5H5N3OM.W. 123.11

Pyrazinamide  Structural Formula Illustration

Each pyrazinamide tablet for oral administration contains 500 mg of pyrazinamide and the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, dibasic calcium phosphate (dihydrate), microcrystalline cellulose, and stearic acid.

What are the possible side effects of pyrazinamide ()?

If you experience any of the following serious side effects, stop taking pyrazinamide and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • a fever;
  • unusual weakness or fatigue;
  • nausea, vomiting, or loss of appetite;
  • yellow skin or eyes;
  • dark urine;
  • difficult or painful urination;
  • painful or swollen joints;
  • ...

Read All Potential Side Effects and See Pictures of Pyrazinamide

What are the precautions when taking pyrazinamide (Pyrazinamide)?

Before taking pyrazinamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, diabetes, gout, high uric acid level in the blood, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Alcohol may increase the risk of liver disease. Avoid alcoholic beverages while using this medication.

Pyrazinamide may cause live bacterial vaccines...

Read All Potential Precautions of Pyrazinamide


Pyrazinamide Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, loss of appetite, or mild muscle/joint pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: symptoms of liver disease (such as persistent nausea/vomiting, unusual tiredness/weakness, severe stomach/abdominal pain, yellowing eyes/skin, dark urine), painful/swollen joints.

Tell your doctor immediately if any of these rare but serious side effects occur: change in the amount of urine, easy bleeding/bruising, fast heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking pyrazinamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, diabetes, gout, high uric acid level in the blood, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Alcohol may increase the risk of liver disease. Avoid alcoholic beverages while using this medication.

Pyrazinamide may cause live bacterial vaccines (such as typhoid vaccine) not to work as well. Therefore, do not have any immunizations/vaccinations while using this medication without the consent of your doctor.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk but the effect on a nursing infant is unknown. Discuss the risks and benefits with your doctor before breast-feeding.


Pyrazinamide Patient Information Including Side Effects

Brand Names:

Generic Name: pyrazinamide (Pronunciation: peer a ZIN a mide)

  • What is pyrazinamide ?
  • What are the possible side effects of pyrazinamide ?
  • What is the most important information I should know about pyrazinamide ?
  • Who should not take pyrazinamide ?
  • How should I take pyrazinamide ?
  • What happens if I miss a dose ?
  • What happens if I overdose ?
  • What should I avoid while taking pyrazinamide ?
  • What other drugs will affect pyrazinamide ?
  • Where can I get more information?

What is pyrazinamide ?

Pyrazinamide is an antibiotic. The exact way that pyrazinamide works is unknown.

Pyrazinamide is used to treat tuberculosis (TB).

Pyrazinamide may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of pyrazinamide ?

If you experience any of the following serious side effects, stop taking pyrazinamide and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • a fever;
  • unusual weakness or fatigue;
  • nausea, vomiting, or loss of appetite;
  • yellow skin or eyes;
  • dark urine;
  • difficult or painful urination;
  • painful or swollen joints;
  • worsening gout; or
  • a rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pyrazinamide ?

Take all of the pyrazinamide that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

Call your doctor immediately if you experience a fever, loss of appetite, nausea and vomiting, painful or swollen joints, yellowing of your skin or eyes, or darkening of your urine.

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