Persantine

DRUG DESCRIPTION

Persantine (dipyridamole USP) is a platelet inhibitor chemically described as 2,2',2'',2'''-[(4,8- Dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]-tetraethanol. It has the following structural formula:

Persantine (dipyridamole) structural formula illustration

Dipyridamole is an odorless yellow crystalline powder, having a bitter taste. It is soluble in dilute acids, methanol and chloroform, and practically insoluble in water.

Persantine (dipyridamole) tablets for oral administration contain:

Active Ingredient TABLETS 25 mg, 50 mg, and 75 mg: dipyridamole USP 25 mg, 50 mg and 75 mg, respectively.

Inactive Ingredients TABLETS 25 mg, 50 mg, and 75 mg: acacia, carnauba wax, corn starch, edible white ink, lactose monohydrate, magnesium stearate, D&C yellow #10 aluminum lake, D&C red #30, helendon aluminum pink lake, sodium benzoate, methylparaben, propylparaben, polyethylene glycol, povidone, sucrose, talc, titanium dioxide, and white wax.

What are the possible side effects of dipyridamole (Persantine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • nosebleed or other bleeding that will not stop;
  • black, bloody, or tarry stools; or
  • coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

  • dizziness;
  • upset stomach, diarrhea,...

Read All Potential Side Effects and See Pictures of Persantine

What are the precautions when taking dipyridamole (Persantine)?

Before taking dipyridamole, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other heart problems (e.g., severe coronary artery disease, recent heart attack, low blood pressure), liver disease.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist that you are using this medication.

During...

Read All Potential Precautions of Persantine


Persantine Consumer (continued)

SIDE EFFECTS: Dizziness, stomach upset, diarrhea, vomiting, headache, and flushing may occur, particularly at first as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but very serious side effects occur: weakness, fainting, stomach pain, pounding/rapid heartbeat, yellowing of eyes/skin, dark urine, unusual bleeding/bruising.

Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, confusion, severe headache, slurred speech, vision changes, weakness on one side of the body.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking dipyridamole, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other heart problems (e.g., severe coronary artery disease, recent heart attack, low blood pressure), liver disease.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist that you are using this medication.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.


Persantine Patient Information Including Side Effects

Brand Names: Persantine

Generic Name: dipyridamole (Pronunciation: dye pir ID a mole)

  • What is dipyridamole (Persantine)?
  • What are the possible side effects of dipyridamole (Persantine)?
  • What is the most important information I should know about dipyridamole (Persantine)?
  • What should I discuss with my healthcare provider before taking dipyridamole (Persantine)?
  • How should I take dipyridamole (Persantine)?
  • What happens if I miss a dose (Persantine)?
  • What happens if I overdose (Persantine)?
  • What should I avoid while taking dipyridamole (Persantine)?
  • What other drugs will affect dipyridamole (Persantine)?
  • Where can I get more information?

What is dipyridamole (Persantine)?

Dipyridamole keeps the platelets in your blood from coagulating (clotting) to prevent blood clots from forming on or around an artificial heart valve.

Dipyridamole is used to prevent blood clots after heart valve replacement surgery.

Dipyridamole may also be used for other purposes not listed in this medication guide.

What are the possible side effects of dipyridamole (Persantine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • nosebleed or other bleeding that will not stop;
  • black, bloody, or tarry stools; or
  • coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

  • dizziness;
  • upset stomach, diarrhea, vomiting;
  • warmth, redness, or tingly feeling under your skin;
  • muscle or joint pain;
  • headache; or
  • mild skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about dipyridamole (Persantine)?

Before taking dipyridamole, tell your doctor if you have liver disease, low blood pressure, coronary artery disease, angina (chest pain), or if you have recently had a heart attack.

Dipyridamole is often taken together with other medications to prevent blood clots. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

To be sure this medication is not causing harmful effects, your doctor may need to check your progress on a regular basis. Do not miss any scheduled visits to your doctor.

While you are taking dipyridamole, do not take aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) without your doctor's advice. NSAIDs include ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.

There may be other drugs that can affect dipyridamole. During your treatment with dipyridamole, you may also be taking another blood thinner such as warfarin (Coumadin). There are many drugs that can interact with blood thinners.

Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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