Nebupent

DRUG DESCRIPTION

NebuPent (pentamidine isethionate), an antifungal agent, is a nonpyrogenic lyophilized product. After reconstitution with Sterile Water for Injection, USP, NebuPent (pentamidine isethionate) is administered by inhalation via the Respirgard® II nebulizer [Marquest, Englewood, CO] (see DOSAGE AND ADMINISTRATION).

Pentamidine isethionate, 4,4'-[1,5-pentane-diylbis(oxy)]bis-benzenecarboximidamid, is a white crystalline powder soluble in water and glycerin and insoluble in ether, acetone, and chloroform.

NebuPent ® (pentamidine isethionate) Structural Formula Illustration

C19H24N4O2•2C2H6O4S            592.68

Each vial contains 300 mg pentamidine isethionate.

What are the possible side effects of pentamidine (Nebupent, Pentam 300)?

Side effects with pentamidine are not common. Serious side effects include:

  • an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting);
  • blurred vision;
  • chest pain or irregular heart beat;
  • difficulty breathing;
  • dizziness, confusion, fainting spells or excessive tiredness;
  • drastic appetite changes;
  • pain or irritation at the injection site;
  • mouth ulcers or...

Read All Potential Side Effects and See Pictures of Nebupent »

What are the precautions when taking pentamidine isethionate (Nebupent)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor, respiratory therapist, or pharmacist your medical history, especially of: bleeding/blood disorders, breathing problems (such as asthma), diabetes, kidney disease, liver problems, smoking.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Pentamidine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can...

Read All Potential Precautions of Nebupent »


Nebupent Consumer (continued)

SIDE EFFECTS: Cough, upset stomach, loss of appetite, nausea, vomiting, diarrhea, dizziness, headache, burning feeling in the throat, or unusual taste/dryness in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor or respiratory therapist immediately if any of these unlikely but serious side effects occur: chest tightness, breathing problems.

Though very unlikely, inhaled pentamidine might be absorbed into your body. Tell your doctor immediately if any of these rare but serious side effects occur: abdominal pain, easy bruising/bleeding, fast/irregular heartbeat, mental/mood changes (such as confusion, hallucinations), unusual decrease in the amount of urine, signs of anemia (such as severe tiredness, bluish skin/nails), signs of low blood pressure (such as severe dizziness, pale skin, fainting), signs of low blood sugar (such as sudden sweating, shaking, fast heartbeat, hunger), signs of high blood sugar (such as unusual increase in thirst or urination), signs of infection (such as fever, chills, persistent sore throat).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor, respiratory therapist, or pharmacist your medical history, especially of: bleeding/blood disorders, breathing problems (such as asthma), diabetes, kidney disease, liver problems, smoking.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Pentamidine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that require immediate medical attention. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may affect the heart rhythm. Before using pentamidine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using pentamidine safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Because breast milk can transmit HIV, do not breast-feed.


Nebupent Patient Information Including Side Effects

Brand Names: Nebupent, Pentam 300

Generic Name: pentamidine (Pronunciation: pen TAM e deen)

  • What is pentamidine (Nebupent)?
  • What are the possible side effects of pentamidine (Nebupent)?
  • What is the most important information I should know about pentamidine (Nebupent)?
  • What should I discuss with my healthcare provider before taking pentamidine (Nebupent)?
  • How should I take pentamidine (Nebupent)?
  • What happens if I miss a dose (Nebupent)?
  • What happens if I overdose (Nebupent)?
  • What should I avoid while taking pentamidine (Nebupent)?
  • What other drugs will affect pentamidine (Nebupent)?
  • Where can I get more information?

What is pentamidine (Nebupent)?

Pentamidine is a type of antibiotic that fights protozoa in the body.

Pentamidine is used to prevent and treat serious infections such as Pneumocystis pneumonia.

Pentamidine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of pentamidine (Nebupent)?

Side effects with pentamidine are not common. Serious side effects include:

  • an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting);
  • blurred vision;
  • chest pain or irregular heart beat;
  • difficulty breathing;
  • dizziness, confusion, fainting spells or excessive tiredness;
  • drastic appetite changes;
  • pain or irritation at the injection site;
  • mouth ulcers or irritations;
  • severe stomach pain;
  • bleeding or bruising;
  • severe headache;
  • chills;
  • increased thirst; or
  • seizures.

Other, less serious side effects may be more likely to occur. Talk to your doctor if you experience

  • taste changes;
  • diarrhea; or
  • nausea or vomiting.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pentamidine (Nebupent)?

Pentamidine may affect blood sugar levels. Contact your doctor if you experience any low blood sugar symptoms including

  • increased appetite;
  • headache;
  • chills, pale skin, shakes, cold sweats; or
  • anxiety.

Pentamidine may affect blood sugar levels. Contact your doctor if you experience any high blood sugar symptoms including

  • increased thirst;
  • loss of appetite;
  • increase in amount or frequency or urination;
  • fruity smelling breath; or
  • drowsiness.

Your doctor may want you to have regular blood, heart function, and blood sugar evaluations during treatment with pentamidine to monitor progress and side effects.

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