Phospholine Iodide

DRUG DESCRIPTION

Chemical name: (2-mercaptoethyl) trimethylammonium iodide O,O-diethyl phosphorothioate

Structural formula

Phospholine Iodide®
  (echothiophate iodide for ophthalmic solution)  Structural Formula Illustration

C9H23INO3PS           M.W 383.23

Echothiophate iodide for ophthalmic solution occurs as a white, crystalline, water-soluble, hygroscopic solid having a slight mercaptan-like odor. When freeze-dried in the presence of potassium acetate, the mixture appears as a white amorphous deposit on the walls of the bottle.

Each package contains materials for dispensing 5 mL of eyedrops: (1) bottle containing sterile echothiophate iodide for ophthalmic solution in one of four potencies [1.5 mg (0.03%), 3 mg (0.06%), 6.25 mg (0.125%), or 12.5 mg (0.25%)] as indicated on the label, with 40 mg potassium acetate in each case. Sodium hydroxide or acetic acid may have been incorporated to adjust pH during manufacturing. (2) a 5 mL bottle of sterile diluent containing chlorobutanol (chloral derivative), 0.55%; mannitol, 1.2%; boric acid, 0.06%; and sodium phosphate, 0.026%. (3) sterilized dropper.

What are the possible side effects of echothiophate iodide ophthalmic (Phospholine Iodide)?

Contact your doctor immediately if you notice any decrease in vision or an increase in "floaters" in your visual field. Rarely, echothiophate iodide ophthalmic may cause retinal detachment. Retinal detachment can lead to blind spots, floaters in your visual field, and even blindness. Your doctor will want to check your retina before you use this medicine to determine if you have an increased risk of retinal detachment.

If you experience any of the following serious side effects, stop using echothiophate iodide...

Read All Potential Side Effects and See Pictures of Phospholine Iodide »

What are the precautions when taking echothiophate iodide for ophthalmic solution (Phospholine Iodide)?

Before using echothiophate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, epilepsy, other eye problems (e.g., iritis, uveitis, detached retina), heart disease (e.g., heart failure, recent heart attack), low or high blood pressure, myasthenia gravis, overactive thyroid (hyperthyroidism), Parkinsonism, stomach/intestinal problems (e.g., ulcers, spasms), certain urinary problems (e.g., blockage).

After you apply echothiophate, your vision may become temporarily blurred or unstable....

Read All Potential Precautions of Phospholine Iodide »


Phospholine Iodide Consumer (continued)

SIDE EFFECTS: Temporary irritation/burning/stinging of the eye, temporary blurred vision, eyelid muscle twitching, poor vision in dim light, headache, or brow ache may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly. (See also Precautions section.)

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: eye pain, flushing, diarrhea, nausea, irregular heartbeat, stomach/abdominal pain or cramps, increased saliva, increased urination, unusual sweating, vision changes.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using echothiophate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, epilepsy, other eye problems (e.g., iritis, uveitis, detached retina), heart disease (e.g., heart failure, recent heart attack), low or high blood pressure, myasthenia gravis, overactive thyroid (hyperthyroidism), Parkinsonism, stomach/intestinal problems (e.g., ulcers, spasms), certain urinary problems (e.g., blockage).

After you apply echothiophate, your vision may become temporarily blurred or unstable. Vision in dim light may be affected. Do not drive (especially at night), use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

Avoid exposure to insecticides. Some types of insecticides may increase the risk of certain side effects. If you have contact with insecticides, wear a mask and/or gloves and wash or change clothing frequently. Consult your doctor or pharmacist for more information.

Before having surgery, tell your doctor or dentist that you are using this medication.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.


Phospholine Iodide Patient Information Including Side Effects

Brand Names: Phospholine Iodide

Generic Name: echothiophate iodide ophthalmic (Pronunciation: eck oh THYE oh fate EYE oh dide)

  • What is echothiophate iodide ophthalmic (Phospholine Iodide)?
  • What are the possible side effects of echothiophate iodide ophthalmic (Phospholine Iodide)?
  • What is the most important information I should know about echothiophate iodide ophthalmic (Phospholine Iodide)?
  • What should I discuss with my healthcare provider before using echothiophate iodide ophthalmic (Phospholine Iodide)?
  • How should I use echothiophate iodide ophthalmic (Phospholine Iodide)?
  • What happens if I miss a dose (Phospholine Iodide)?
  • What happens if I overdose (Phospholine Iodide)?
  • What should I avoid while using echothiophate iodide ophthalmic (Phospholine Iodide)?
  • What other drugs will affect echothiophate iodide ophthalmic (Phospholine Iodide)?
  • Where can I get more information?

What is echothiophate iodide ophthalmic (Phospholine Iodide)?

Echothiophate iodide ophthalmic reduces pressure in the eye by increasing the amount of fluid that drains from the eye. Echothiophate iodide ophthalmic also causes the pupil to become smaller and reduces its response to light or dark conditions.

Echothiophate iodide ophthalmic is used to treat glaucoma by lowering the pressure inside the eye. Echothiophate iodide ophthalmic is also used to treat certain eye disorders involving eye accommodation (focusing).

Echothiophate iodide ophthalmic may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of echothiophate iodide ophthalmic (Phospholine Iodide)?

Contact your doctor immediately if you notice any decrease in vision or an increase in "floaters" in your visual field. Rarely, echothiophate iodide ophthalmic may cause retinal detachment. Retinal detachment can lead to blind spots, floaters in your visual field, and even blindness. Your doctor will want to check your retina before you use this medicine to determine if you have an increased risk of retinal detachment.

If you experience any of the following serious side effects, stop using echothiophate iodide ophthalmic and seek emergency medical attention:

  • an allergic reaction (shortness of breath; swelling of the lips, face, or tongue; or hives);
  • abdominal cramps or diarrhea;
  • watering mouth;
  • excessive sweating;
  • urinary incontinence;
  • muscle weakness;
  • difficulty breathing; or
  • an irregular heart beat.

Other, less serious side effects may be more likely to occur. Continue to use echothiophate iodide ophthalmic and talk to your doctor if you experience

  • burning, stinging, red, or tearing eyes;
  • eyelid muscle twitches;
  • headache or brow ache; or
  • decreased vision in poor light.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about echothiophate iodide ophthalmic (Phospholine Iodide)?

Contact your doctor immediately if you notice any decrease in vision or an increase in "floaters" in your visual field. Rarely, echothiophate iodide ophthalmic may cause retinal detachment. Retinal detachment can lead to blind spots, floaters in your visual field, and even blindness. Your doctor will want to check your retina before you use this medicine to determine if you have an increased risk of retinal detachment.

Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye.

Apply light pressure to the inside corner of the eye (near the nose) after each drop to prevent the fluid from draining down the tear duct.

Use caution when driving, operating machinery, or performing other hazardous activities. Echothiophate iodide ophthalmic may cause decreased vision at night. If you experience decreased vision, avoid these activities.

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