Primacor IV

DRUG DESCRIPTION

PRIMACOR, brand of milrinone lactate injection, is a member of a class of bipyridine inotropic/vasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines. PRIMACOR (milrinone lactate) is designated chemically as 1,6-dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile lactate and has the following structure:

PRIMACOR® (MILRINONE LACTATE) Structural Formula Illustration

Milrinone is an off-white to tan crystalline compound with a molecular weight of 211.2 and an empirical formula of C12 H9 N3 O. It is slightly soluble in methanol, and very slightly soluble in chloroform and in water. As the lactate salt, it is stable and colorless to pale yellow in solution. PRIMACOR is available as sterile aqueous solutions of the lactate salt of milrinone for infusion intravenously.

Pre-Mix Flexible Containers: The Flexible Containers provide two ready-to-use dilutions of milrinone in volumes of 100 mL and 200 mL of 5% Dextrose Injection. Each mL contains milrinone lactate equivalent to 200 mcg milrinone. The nominal concentration of lactic acid is 0.282 mg/mL. Each mL also contains 49.4 mg dextrose, anhydrous, USP. The pH is adjusted to between 3.2 and 4.0 with lactic acid or sodium hydroxide. The flexible plastic container is comprised of polyvinyl chloride with a foil overwrap. Water can permeate the plastic into the overwrap, but the amount is insufficient to significantly affect the pre-mix solution.

What are the possible side effects of milrinone (Primacor)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • chest pain;
  • feeling like you might pass out;
  • bronchospasm (wheezing, chest tightness, trouble breathing); or
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).

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Primacor IV Patient Information Including Side Effects

Brand Names: Primacor

Generic Name: milrinone (Pronunciation: MIL ri none)

  • What is milrinone (Primacor IV)?
  • What are the possible side effects of milrinone (Primacor IV)?
  • What is the most important information I should know about milrinone (Primacor IV)?
  • What should I discuss with my healthcare provider before I receive milrinone (Primacor IV)?
  • How is milrinone given (Primacor IV)?
  • What happens if I miss a dose (Primacor IV)?
  • What happens if I overdose (Primacor IV)?
  • What should I avoid after receiving milrinone (Primacor IV)?
  • What other drugs will affect milrinone (Primacor IV)?
  • Where can I get more information?

What is milrinone (Primacor IV)?

Milrinone is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries.

Milrinone is used as a short-term treatment for treat life-threatening heart failure.

Milrinone may also be used for other purposes not listed in this medication guide.

What are the possible side effects of milrinone (Primacor IV)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • chest pain;
  • feeling like you might pass out;
  • bronchospasm (wheezing, chest tightness, trouble breathing); or
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).

Less serious side effects may include:

  • headache;
  • tremors; or
  • easy bruising or bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about milrinone (Primacor IV)?

You should not receive this medication if you are allergic to milrinone, or if you have recently had a heart attack.

If possible before you receive milrinone, tell your doctor if you have a heart rhythm disorder or low levels of potassium in your blood (hypokalemia), or if you are pregnant or breast-feeding.

In an emergency situation, it may not be possible before you are treated to tell your caregivers about any health conditions you have or if you are pregnant or breast-feeding. However, make sure any doctor caring for you afterward knows that you have received this medication.

Tell your doctor about all other medications you use, especially digoxin (digitalis, Lanoxin, Lanoxicaps), or a diuretic (water pill).

While receiving milrinone, tell your caregivers at once if you have a serious side effect such as chest pain, feeling like you might pass out, wheezing or trouble breathing, confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, or muscle weakness.

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