Ipol

DRUG DESCRIPTION

IPOL®, Poliovirus Vaccine Inactivated, produced by Sanofi Pasteur SA, is a sterile suspension of three types of poliovirus: Type 1 (Mahoney), Type 2 (MEF-1), and Type 3 (Saukett). IPOL (poliovirus vaccine inactivated) vaccine is a highly purified, inactivated poliovirus vaccine with enhanced potency. Each of the three strains of poliovirus is individually grown in vero cells, a continuous line of monkey kidney cells cultivated on microcarriers.1,2 The cells are grown in Eagle MEM modified medium, supplemented with newborn calf serum tested for adventitious agents prior to use, originated from countries free of bovine spongiform encephalopathy. For viral growth the culture medium is replaced by M-199, without calf serum. This culture technique and improvements in purification, concentration and standardization of poliovirus antigen produce a more potent and consistent immunogenic vaccine than the inactivated poliovirus vaccine (IPV) available in the US prior to 1988.3,4

After clarification and filtration, viral suspensions are concentrated by ultrafiltration, and purified by three liquid chromatography steps; one column of anion exchanger, one column of gel filtration and again one column of anion exchanger. After re-equilibration of the purified viral suspension, with Medium M-199 and adjustment of the antigen titer, the monovalent viral suspensions are inactivated at +37°C for at least 12 days with 1:4000 formalin.

Each dose (0.5 mL) of trivalent vaccine is formulated to contain 40 D antigen units of Type 1, 8 D antigen units of Type 2, and 32 D antigen units of Type 3 poliovirus. For each lot of IPOL (poliovirus vaccine inactivated) vaccine, D-antigen content is determined in vitro using the D-antigen ELISA assay and immunogenicity is determined by in vivo testing in animals. IPOL (poliovirus vaccine inactivated) vaccine is produced from vaccine concentrates diluted with M-199 medium. Also present are 0.5% of 2-phenoxyethanol and a maximum of 0.02% of formaldehyde per dose as preservatives. Neomycin, streptomycin and polymyxin B are used in vaccine production, and although purification procedures eliminate measurable amounts, less than 5 ng neomycin, 200 ng streptomycin and 25 ng polymyxin B per dose may still be present. The residual calf serum protein is less than 1 ppm in the final vaccine.

The vaccine is clear and colorless and should be administered intramuscularly or subcutaneously.

What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely...

Read All Potential Side Effects and See Pictures of Ipol »

What are the precautions when taking poliovirus vaccine inactivated (Ipol)?

Before receiving poliovirus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, streptomycin, polymyxin B, 2-phenoxyethanol, formaldehyde), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccine, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as due to cancer treatment, HIV infection).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly...

Read All Potential Precautions of Ipol »

What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely...

Read All Potential Side Effects and See Pictures of Ipol »

What are the precautions when taking poliovirus vaccine inactivated (Ipol)?

Before receiving poliovirus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, streptomycin, polymyxin B, 2-phenoxyethanol, formaldehyde), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccine, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as due to cancer treatment, HIV infection).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly...

Read All Potential Precautions of Ipol »

What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely...

Read All Potential Side Effects and See Pictures of Ipol »

What are the precautions when taking poliovirus vaccine inactivated (Ipol)?

Before receiving poliovirus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, streptomycin, polymyxin B, 2-phenoxyethanol, formaldehyde), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccine, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as due to cancer treatment, HIV infection).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly...

Read All Potential Precautions of Ipol »

What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely...

Read All Potential Side Effects and See Pictures of Ipol »

What are the precautions when taking poliovirus vaccine inactivated (Ipol)?

Before receiving poliovirus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, streptomycin, polymyxin B, 2-phenoxyethanol, formaldehyde), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccine, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as due to cancer treatment, HIV infection).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly...

Read All Potential Precautions of Ipol »

What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely...

Read All Potential Side Effects and See Pictures of Ipol »

What are the precautions when taking poliovirus vaccine inactivated (Ipol)?

Before receiving poliovirus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, streptomycin, polymyxin B, 2-phenoxyethanol, formaldehyde), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccine, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as due to cancer treatment, HIV infection).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly...

Read All Potential Precautions of Ipol »

What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely...

Read All Potential Side Effects and See Pictures of Ipol »

What are the precautions when taking poliovirus vaccine inactivated (Ipol)?

Before receiving poliovirus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, streptomycin, polymyxin B, 2-phenoxyethanol, formaldehyde), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccine, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as due to cancer treatment, HIV infection).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly...

Read All Potential Precautions of Ipol »


Ipol Consumer (continued)

SIDE EFFECTS: Redness/swelling/tenderness at the injection site, fever, irritability, and tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Contact the doctor for medical advice about side effects. The following numbers do not provide medical advice, but in the US you may report side effects to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967. In Canada, you may call Health Canada at 1-866-234-2345.

PRECAUTIONS: Before receiving poliovirus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, streptomycin, polymyxin B, 2-phenoxyethanol, formaldehyde), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccine, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as due to cancer treatment, HIV infection).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this vaccine passes into breast milk. Consult your doctor before breast-feeding.


Ipol Patient Information Including Side Effects

Brand Names: Ipol

Generic Name: polio vaccine (IPV) (Pronunciation: POE lee oh)

  • What is polio vaccine (Ipol)?
  • What are the possible side effects of polio vaccine (Ipol)?
  • What is the most important information I should know about polio vaccine (Ipol)?
  • What should I discuss with my healthcare provider before receiving polio vaccine (Ipol)?
  • How is polio vaccine administered (Ipol)?
  • What happens if I miss a dose (Ipol)?
  • What happens if I overdose (Ipol)?
  • What should I avoid before or after getting polio vaccine (Ipol)?
  • What other drugs will affect polio vaccine (Ipol)?
  • Where can I get more information?

What is polio vaccine (Ipol)?

Polio affects the central nervous system and spinal cord. It can cause muscle weakness and paralysis. Polio is a life-threatening condition because it can paralyze the muscles that help you breathe.

The polio vaccine is used to help prevent these diseases in children.

This vaccine works by exposing you to a small dose of the bacteria or a protein from the bacteria, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body.

Polio vaccine is for use in adults and children who are at least 2 months old.

Like any vaccine, the polio vaccine may not provide protection from disease in every person.

What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • extreme drowsiness, fainting;
  • seizure (black-out or convulsions); or
  • high fever (within a few hours or a few days after the vaccine).

Less serious side effects include:

  • redness, pain, swelling, or a lump where the shot was given;
  • low fever;
  • joint pain, body aches;
  • drowsiness; or
  • vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

What is the most important information I should know about polio vaccine (Ipol)?

The polio vaccine is given in a series of shots. The number of shots required and the booster schedule will depend on the age of the person being vaccinated. Follow your doctor's instructions or the schedule recommended by the health department of the state you live in.

Be sure you receive all recommended doses of this vaccine. If you do not receive the full series of vaccines, you may not be fully protected against the disease.

You can still receive a vaccine if you have a cold or fever. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

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