Questran

DRUG DESCRIPTION

QUESTRAN® (Cholestyramine for Oral Suspension USP), the chloride salt of a basic anion exchange resin, a cholesterol lowering agent, is intended for oral administration. Cholestyramine resin is quite hydrophilic, but insoluble in water. The cholestyramine resin in QUESTRAN (cholestyramine) is not absorbed from the digestive tract. Four grams of anhydrous cholestyra-mine resin is contained in 9 grams of QUESTRAN powder. Four grams of anhydrous cholestyramine resin is contained in 5 grams of QUESTRAN (cholestyramine) LIGHT. It is represented by the following structural formula:

QUESTRAN®  (Cholestyramine for Oral Suspension USP)   Structural Formula Illustration

QUESTRAN (cholestyramine) powder contains the following inactive ingredients:acacia, citric acid, D&C Yellow No. 10, FD&C Yellow No.6, flavor (natural and artificial Orange), polysorbate 80, propylene glycol alginate and sucrose. QUESTRAN (cholestyramine) LIGHT contains the following inactive ingredients: aspartame, citric acid, colloidal silicon dioxide, D&C Yellow No. 10, FD&C Red No.40, flavor (natural and artificial Orange), maltodextrin, propylene glycol alginate and xanthan gum.

What are the possible side effects of cholestyramine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • blood in your urine;
  • severe stomach pain;
  • ongoing constipation;
  • feeling short of breath;
  • black, bloody, or tarry stools; or
  • easy bruising or bleeding.

Less serious side effects may include:

  • mild constipation,...

Read All Potential Side Effects and See Pictures of Questran »

What are the precautions when taking cholestyramine (Questran)?

Before taking cholestyramine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: constipation, hemorrhoids, kidney disease.

Some products may contain sugar or aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Because this drug can interfere with the absorption of certain nutrients (such as folic acid, fat-soluble...

Read All Potential Precautions of Questran »


Questran Consumer (continued)

SIDE EFFECTS: Constipation, stomach/abdominal pain, gas, nausea, and vomiting may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated while using this drug, consult your pharmacist for help in selecting a stool softener and/or a laxative.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but serious side effects occur: severe stomach/abdominal pain, unusual bleeding/bruising, rapid breathing, confusion.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking cholestyramine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: constipation, hemorrhoids, kidney disease.

Some products may contain sugar or aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Because this drug can interfere with the absorption of certain nutrients (such as folic acid, fat-soluble vitamins including A, D, E, K), your doctor may direct you to take a multivitamin supplement. Consult your doctor for more information.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially constipation.

During pregnancy, this medication should be used only when clearly needed. It may affect the absorption of certain nutrients. Discuss the risks and benefits with your doctor.

This medication is unlikely to pass into breast milk. However, it may affect the absorption of certain nutrients. Consult your doctor before breast-feeding.


Questran Patient Information Including Side Effects

Brand Names: Cholestyramine Light, Locholest, Locholest Light, Prevalite, Questran, Questran Light

Generic Name: cholestyramine (Pronunciation: koe le STYE ra meen)

  • What is cholestyramine (Questran)?
  • What are the possible side effects of cholestyramine?
  • What is the most important information I should know about cholestyramine?
  • What should I discuss with my healthcare provider before taking cholestyramine?
  • How should I take cholestyramine?
  • What happens if I miss a dose?
  • What happens if I overdose?
  • What should I avoid while taking cholestyramine?
  • What other drugs will affect cholestyramine?
  • Where can I get more information?

What is cholestyramine (Questran)?

Cholestyramine helps reduce cholesterol (fatty acids) in the blood. High cholesterol is associated with an increased risk of heart disease and atherosclerosis (clogged arteries).

Cholestyramine is used to lower high levels of cholesterol in the blood, especially low-density lipoprotein (LDL) ("bad" cholesterol).

Cholestyramine powder is also used to treat itching caused by a blockage in the bile ducts of the gallbladder.

Cholestyramine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of cholestyramine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • blood in your urine;
  • severe stomach pain;
  • ongoing constipation;
  • feeling short of breath;
  • black, bloody, or tarry stools; or
  • easy bruising or bleeding.

Less serious side effects may include:

  • mild constipation, diarrhea;
  • stomach pain, nausea, loss of appetite, weight changes;
  • bloating or gas;
  • hiccups or a sour taste in your mouth;
  • skin rash or itching;
  • irritation of your tongue;
  • itching or irritation around your rectal area;
  • muscle or joint pain; or
  • dizziness, spinning sensation; ringing in your ears.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about cholestyramine?

You should not take this medication if you are allergic to cholestyramine, or if you have a blockage in your stomach or intestines.

Before taking cholestyramine, tell your doctor if you have a thyroid disorder, diabetes, kidney or liver disease, or chronic constipation.

Avoid taking other medications at the same time you take cholestyramine. Wait at least 4 to 6 hours after taking cholestyramine before you take any other medications.

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