Rabavert

DRUG DESCRIPTION

RabAvert, rabies vaccine, produced by Chiron Behring GmbH & Co is a sterile freeze-dried vaccine obtained by growing the fixed-virus strain Flury LEP in primary cultures of chicken fibroblasts. The strain Flury LEP was obtained from American Type Culture Collection as the 59th egg passage. The growth medium for propagation of the virus is a synthetic cell culture medium with the addition of human albumin, polygeline (processed bovine gelatin) and antibiotics. The virus is inactivated with beta-propiolactone, and further processed by zonal centrifugation in a sucrose density-gradient. The vaccine is lyophilized after addition of a stabilizer solution, which consists of buffered polygeline and potassium glutamate. One dose of reconstituted vaccine contains less than 12 mg polygeline (processed bovine gelatin), 1 mg potassium glutamate and 0.3 mg sodium EDTA. Small quantities of bovine serum are used in the cell culture process. Testing of the product components and excipients using currently available methods has not detected any adventitious agents. Further, bovine components originate only from source countries known to be free of bovine spongioform encephalopathy. Minimal amounts of chicken protein may be present in the final product; ovalbumin content is less than 3 ng/dose (1 mL), based on ELISA. Antibiotics (neomycin, chlortetracycline, amphotericin B) added during cell and virus propagation are largely removed during subsequent steps in the manufacturing process. In the final vaccine, neomycin is present at < 1 mcg, chlortetracycline at < 20 ng, and amphotericin B at < 2 ng per dose. RabAvert (rabies vaccine) is intended for intramuscular (IM) injection. The vaccine contains no preservative and should be used immediately after reconstitution with the supplied diluent (Water For Injection, USP). The potency of the final product is determined by the NIH mouse potency test using the US reference standard. The potency of one dose (1.0 mL) RabAvert (rabies vaccine) is at least 2.5 IU of rabies antigen. RabAvert (rabies vaccine) is a white, freeze-dried vaccine for reconstitution with the diluent prior to use; the reconstituted vaccine is a clear to slightly opaque, colorless suspension.

What are the possible side effects of rabies vaccine (RabAvert)?

Keep track of any and all side effects you have after receiving this vaccine. When you receive another vaccine in the future, you will need to tell the doctor if the first shot caused any side effects. Getting rabies disease is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects. The risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face,...

Read All Potential Side Effects and See Pictures of Rabavert


Rabavert Patient Information Including Side Effects

Brand Names: RabAvert

Generic Name: rabies vaccine, purified chick embryo cell (Pronunciation: RAY beez vax EEN, PYUR if eyed CHIK EM bree o sel)

  • What is rabies vaccine (Rabavert)?
  • What are the possible side effects of rabies vaccine (Rabavert)?
  • What is the most important information I should know about rabies vaccine (Rabavert)?
  • What should I discuss with my healthcare provider before receiving rabies vaccine (Rabavert)?
  • How is rabies vaccine given (Rabavert)?
  • What happens if I miss a dose (Rabavert)?
  • What happens if I overdose (Rabavert)?
  • What should I avoid before or after getting rabies vaccine (Rabavert)?
  • What other drugs will affect rabies vaccine (Rabavert)?
  • Where can I get more information?

What is rabies vaccine (Rabavert)?

Rabies is a serious disease caused by a virus. Rabies is mainly a disease of animals. Humans get rabies when they are bitten by an infected animal. There may be no symptoms at first, but weeks or even years after a bite from an infected animal, rabies can cause pain, fatigue, headaches, irritability, fever, seizures, hallucinations, and paralysis. Rabies can be fatal.

You are more likely to be exposed to the rabies virus if you are a veterinarian, animal handler, rabies laboratory worker, or may otherwise come into contact with animals that could possibly carry the virus (including cats, dogs, foxes, skunks, raccoons, bobcats, coyotes, and bats). Travel to certain countries may also increase your risk of exposure to rabies.

Rabies purified chick embryo cell vaccine is used to prevent rabies in people who have been bitten by an animal or otherwise exposed to the rabies virus.

What are the possible side effects of rabies vaccine (Rabavert)?

Keep track of any and all side effects you have after receiving this vaccine. When you receive another vaccine in the future, you will need to tell the doctor if the first shot caused any side effects. Getting rabies disease is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects. The risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever, chills, weakness, body aches, flu symptoms;
  • severe headache, problems with your vision;
  • numbness or tingly feeling;
  • swollen lymph glands; or
  • skin rash.

Less serious side effects may include:

  • pain, swelling, itching, or redness where the shot was given;
  • headache;
  • increased heart rate;
  • hot flashes;
  • muscle pain; or
  • nausea, stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

What is the most important information I should know about rabies vaccine (Rabavert)?

Keep track of any and all side effects you have after receiving this vaccine. When you receive another vaccine in the future, you will need to tell the doctor if the first shot caused any side effects. Getting rabies disease is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects. The risk of serious side effects is extremely low.

You can still receive a rabies vaccine if you have a cold or other minor illness. If you have a more severe illness with a fever, wait until you recover before receiving this vaccine. However, if you have been bitten by an infected animal or otherwise exposed to the rabies virus, you should receive the rabies vaccine regardless of having another illness.

Related Drug Centers
  • Rabavert


Related Drugs Index: