Rapaflo Capsules

DRUG DESCRIPTION

RAPAFLO is the brand name for silodosin, a selective antagonist of alpha-1 adrenoreceptors. The chemical name of silodosin is 1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide and the molecular formula is C25H32F3N3O4 with a molecular weight of 495.53. The structural formula of silodosin is:

RAPAFLO®
  (silodosin)  Structural Formula Illustration

Silodosin is a white to pale yellowish white powder that melts at approximately 105 to 109°C. It is very soluble in acetic acid, freely soluble in alcohol, and very slightly soluble in water.

Each RAPAFLO 8 mg capsule for oral administration contains 8 mg silodosin, and the following inactive ingredients: D-mannitol, magnesium stearate, pregelatinized starch, and sodium lauryl sulfate. The size #1 hard gelatin capsules contain gelatin and titanium dioxide. The capsules are printed with edible ink containing FD&C Blue No. 1 Aluminum Lake and yellow iron oxide.

Each RAPAFLO 4 mg capsule for oral administration contains 4 mg silodosin, and the following inactive ingredients: D-mannitol, magnesium stearate, pregelatinized starch, and sodium lauryl sulfate. The size #3 hard gelatin capsules contain gelatin and titanium dioxide. The capsules are printed with edible ink containing yellow iron oxide.

What are the possible side effects of silodosin (Rapaflo)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using silodosin and call your doctor at once if you have a serious side effect such as:

  • severe dizziness;
  • feeling like you might pass out;
  • jaundice (yellowing of the skin or eyes); or
  • penis erection that is painful or lasts 4 hours or longer.

Less serious side effects may include:

  • mild dizziness,...

Read All Potential Side Effects and See Pictures of Rapaflo Capsules »


Rapaflo Capsules Patient Information Including Side Effects

Brand Names: Rapaflo

Generic Name: silodosin (Pronunciation: SIL oh DOE sin)

  • What is silodosin (Rapaflo Capsules)?
  • What are the possible side effects of silodosin (Rapaflo Capsules)?
  • What is the most important information I should know about silodosin (Rapaflo Capsules)?
  • What should I discuss with my health care provider before taking silodosin (Rapaflo Capsules)?
  • How should I take silodosin (Rapaflo Capsules)?
  • What happens if I miss a dose (Rapaflo Capsules)?
  • What happens if I overdose (Rapaflo Capsules)?
  • What should I avoid while taking silodosin (Rapaflo Capsules)?
  • What other drugs will affect silodosin (Rapaflo Capsules)?
  • Where can I get more information?

What is silodosin (Rapaflo Capsules)?

Silodosin is in a group of drugs called alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Silodosin helps relax the muscles in the prostate and bladder neck, making it easier to urinate.

Silodosin is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Silodosin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of silodosin (Rapaflo Capsules)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using silodosin and call your doctor at once if you have a serious side effect such as:

  • severe dizziness;
  • feeling like you might pass out;
  • jaundice (yellowing of the skin or eyes); or
  • penis erection that is painful or lasts 4 hours or longer.

Less serious side effects may include:

  • mild dizziness, weakness;
  • headache;
  • sleep problems (insomnia);
  • diarrhea, stomach pain;
  • decreased amount of semen released during sex; or
  • runny or stuffy nose, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about silodosin (Rapaflo Capsules)?

You should not use silodosin if you have severe kidney or liver disease, or if you are also using ketoconazole (Nizoral), itraconazole (Sporanox), or ritonavir (Norvir).

Before taking silodosin, tell your doctor if you have kidney or liver disease, or prostate cancer.

Also tell your doctor about all other medications you use, especially other prostate medications, antibiotics, HIV/AIDS medications, or heart or blood pressure medications.

Silodosin should be taken with food to reduce the chance of side effects.

Silodosin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Silodosin can affect the pupils of your eyes during cataract surgery. If you have cataract surgery while you are taking silodosin, or even long after you stop taking it, tell the surgeon ahead of time that you have taken this medication. Do not stop using silodosin before surgery unless your surgeon tells you to.

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