Relistor

DRUG DESCRIPTION

RELISTOR (methylnaltrexone bromide) Subcutaneous Injection, a peripherally-acting muopioid receptor antagonist, is a sterile, clear and colorless to pale yellow aqueous solution. The chemical name for methylnaltrexone bromide is (R)-N-(cyclopropylmethyl) noroxymorphone methobromide. The molecular formula is C21H26NO4Br, and the molecular weight is 436.36. Each 3 mL vial contains 12 mg of methylnaltrexone bromide in 0.6 mL of water. The excipients are 3.9 mg sodium chloride USP, 0.24 mg edetate calcium disodium USP, and 0.18 mg glycine hydrochloride. During manufacture, the pH may have been adjusted with hydrochloric acid and/or sodium hydroxide.

The structural formula is:

RELISTOR (methylnaltrexone bromide) structural formula illustration

What are the possible side effects of methylnaltrexone (Relistor)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe or ongoing diarrhea, stomach pain that will not go away, or nausea or vomiting that are new or worsening symptoms.

Less serious side effects may include:

  • stomach pain, gas;
  • mild nausea; or
  • mild diarrhea.

This is not a complete list of side effects and others may occur. Tell...

Read All Potential Side Effects and See Pictures of Relistor


Relistor Patient Information Including Side Effects

Brand Names: Relistor

Generic Name: methylnaltrexone (Pronunciation: METh IL nal TREX own)

  • What is methylnaltrexone (Relistor)?
  • What are the possible side effects of methylnaltrexone (Relistor)?
  • What is the most important information I should know about methylnaltrexone (Relistor)?
  • What should I discuss with my health care provider before receiving methylnaltrexone (Relistor)?
  • How is methylnaltrexone used (Relistor)?
  • What happens if I miss a dose (Relistor)?
  • What happens if I overdose (Relistor)?
  • What should I avoid while using methylnaltrexone (Relistor)?
  • What other drugs will affect methylnaltrexone (Relistor)?
  • Where can I get more information?

What is methylnaltrexone (Relistor)?

Methylnaltrexone is a special narcotic drug that blocks certain effects of other narcotic medicines.

Methylnaltrexone reduces constipation caused by narcotic medications that are often used to treat pain in people with terminal illness.

Methylnaltrexone works by preventing this side effect without reducing the pain-relieving effects of the narcotic.

Methylnaltrexone is usually given after laxatives have been tried without successful treatment of constipation.

Methylnaltrexone may also be used for other purposes not listed in this medication guide.

What are the possible side effects of methylnaltrexone (Relistor)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe or ongoing diarrhea, stomach pain that will not go away, or nausea or vomiting that are new or worsening symptoms.

Less serious side effects may include:

  • stomach pain, gas;
  • mild nausea; or
  • mild diarrhea.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about methylnaltrexone (Relistor)?

You should not use this medication if you are allergic to methylnaltrexone, or if you have a blockage in your stomach or intestines.

Before you use methylnaltrexone, tell your doctor if you have severe or ongoing diarrhea.

Do not draw your methylnaltrexone dose into a syringe until you are ready to give yourself an injection. After loading a syringe, if you cannot give the injection right away keep it at room temperature and use it within 24 hours.

Methylnaltrexone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

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