SKLICE (ivermectin) Lotion, for topical administration, is an off-white/tan lotion containing 0.5% ivermectin.

Ivermectin, the active ingredient, is a pediculicide, derived from the fermentation of a soil dwelling actinomycete, Streptomyces avermitilis.

Ivermectin is a mixture containing at least 90% 5-O-demethyl-22,23-dihydroavermectin A_1a and less than 10% 5-O-demethyl-25-de(l -methylpropyl)-22,23-dihydro25-(l-methylethyl) avermectin A_1a, generally referred to as 22,23-dihydroavermectin B_1a and B_1b, or H₂B_1a and H₂B_1b, respectively. The respective empirical formulas are C₄₈H₇₄O₁₄ and C₄₇H₇₂O₁₄, with molecular weights of 875.10 and 861.07, respectively. The structural formulas are:

Component H₂B_1a: R = CH₂CH₃     Component H₂B_1b: R = CH₃

SKLICE Lotion contains the following inactive ingredients: water, olive oil, oleyl alcohol, Crodalan AWS, lanolin alcohol, cyclomethicone, shea butter, sodium citrate, sorbitan tristearate, methylparaben, propylparaben, and citric acid.