Talwin Nx

DRUG DESCRIPTION

TALWIN NX (pentazocine and naloxone hydrochlorides, USP) contains pentazocine hydrochloride, USP, equivalent to 50 mg base and is a member of the benzazocine series (also known as the benzomorphan series), and naloxone hydrochloride, USP, equivalent to 0.5 mg base.

TALWIN NX (pentazocine and naloxone) is an analgesic for oral administration.

Chemically, pentazocine hydrochloride is (2R*,6R*,11R*)-l,2,3,4,5,6-Hexahydro-6,ll-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride, a white, crystalline substance soluble in acidic aqueous solutions, and has the following structural formula:

pentazocine hydrochloride Structural Formula Illustration

C19H27NO·HCl............M.W. 321.88

Chemically, naloxone hydrochloride is Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, (5?)-. It is a slightly off-white powder, and is soluble in water and dilute acids, and has the following structural formula:


C19H21NO4·HCl..............M.W.=363.84

Inactive Ingredients: Colloidal Silicon Dioxide, Dibasic Calcium Phosphate, D&C Yellow #10, FD&C Yellow #6, Magnesium Stearate, Microcrystalline Cellulose, Sodium Lauryl Sulfate, Starch.

What are the possible side effects of naloxone and pentazocine (Talwin NX)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using naloxone and pentazocine and call your doctor at once if you have any of these serious side effects:

  • confusion, hallucinations;
  • fast heart rate;
  • weak or shallow breathing;
  • chest pain;
  • seizure (convulsions);
  • cold, clammy skin;
  • tremors;
  • confusion, unusual...

Read All Potential Side Effects and See Pictures of Talwin Nx »

What are the precautions when taking pentazocine and naloxone (Talwin Nx)?

Before taking this product, tell your doctor or pharmacist if you are allergic to pentazocine or naloxone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain bowel diseases (paralytic ileus, infectious diarrhea).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, lung disease (such as asthma, chronic obstructive pulmonary disease-COPD), a certain spinal problem (kyphoscoliosis), breathing problems (such as...

Read All Potential Precautions of Talwin Nx »


Talwin Nx Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, increased sweating, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: fainting, mental/mood changes (such as agitation, hallucinations, confusion), difficulty urinating, vision changes, fast heartbeat.

Tell your doctor immediately if these rare but very serious side effects occur: slow/shallow breathing, severe stomach/abdominal pain, change in the amount of urine, signs of infection (such as fever, persistent sore throat), seizures.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking this product, tell your doctor or pharmacist if you are allergic to pentazocine or naloxone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain bowel diseases (paralytic ileus, infectious diarrhea).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, lung disease (such as asthma, chronic obstructive pulmonary disease-COPD), a certain spinal problem (kyphoscoliosis), breathing problems (such as slow/shallow breathing, sleep apnea), certain heart problems (irregular heartbeat), personal or family history of regular use/abuse of drugs/alcohol, brain disorders (such as seizures, head injury, tumor, increased intracranial pressure), underactive thyroid (hypothyroidism), difficulty urinating (for example, due to enlarged prostate or narrowed urethra), disease of the pancreas (such as pancreatitis), mental/mood disorders (such as toxic psychosis), gallbladder disease, adrenal gland problem (such as Addison's disease), intestinal disorders (such as colitis, blockage).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist that you are using this medication.

To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Older adults may be more sensitive to the effects of this drug, especially slow/shallow breathing and drowsiness.

During pregnancy, this medication should be used only when clearly needed. Using it for long periods or in high doses near the expected delivery date is not recommended because of possible harm to the unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have used this medication for a long time may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, or diarrhea. Tell your doctor immediately if you notice any of these symptoms in your newborn.

It is unknown if this product passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding.


Talwin Nx Patient Information Including Side Effects

Brand Names: Talwin NX

Generic Name: naloxone and pentazocine (oral) (Pronunciation: nal OX one and pen TAZ oh seen)

  • What is naloxone and pentazocine (Talwin Nx)?
  • What are the possible side effects of naloxone and pentazocine (Talwin Nx)?
  • What is the most important information I should know about naloxone and pentazocine (Talwin Nx)?
  • What should I discuss with my health care provider before taking naloxone and pentazocine (Talwin Nx)?
  • How should I take naloxone and pentazocine (Talwin Nx)?
  • What happens if I miss a dose (Talwin Nx)?
  • What happens if I overdose (Talwin Nx)?
  • What should I avoid while taking naloxone and pentazocine (Talwin Nx)?
  • What other drugs will affect naloxone and pentazocine (Talwin Nx)?
  • Where can I get more information?

What is naloxone and pentazocine (Talwin Nx)?

Pentazocine is in a group of drugs called narcotic pain relievers.

Naloxone is an special narcotic drug that reverses the effects of other narcotic medicines.

The combination of naloxone and pentazocine is used to treat moderate-to-severe pain. Naloxone is included in this combination to prevent the misuse of the narcotic ingredient.

Naloxone and pentazocine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of naloxone and pentazocine (Talwin Nx)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using naloxone and pentazocine and call your doctor at once if you have any of these serious side effects:

  • confusion, hallucinations;
  • fast heart rate;
  • weak or shallow breathing;
  • chest pain;
  • seizure (convulsions);
  • cold, clammy skin;
  • tremors;
  • confusion, unusual thoughts or behavior;
  • severe anxiety or restlessness; or
  • feeling like you might pass out.

Less serious side effects may include:

  • dizziness, drowsiness;
  • headache, weakness;
  • sleep problems (insomnia), strange dreams;
  • diarrhea, constipation;
  • nausea, vomiting, loss of appetite;
  • warmth, redness, or tingly feeling under your skin;
  • sweating;
  • blurred vision; or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about naloxone and pentazocine (Talwin Nx)?

Never crush a naloxone and pentazocine tablet to mix into a liquid for injecting the drug into your vein. This practice has resulted in death with the misuse of pentazocine and similar prescription drugs.

Pentazocine may be habit-forming and should be used only by the person it was prescribed for. Naloxone and pentazocine should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Do not drink alcohol while you are taking naloxone and pentazocine. Alcohol can increase some of the side effects of narcotic pain medicine.

Never take more than your prescribed dose of naloxone and pentazocine. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Naloxone and pentazocine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Do not stop using naloxone and pentazocine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

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