Tequin

DRUG DESCRIPTION

TEQUIN contains gatifloxacin, a synthetic broad-spectrum 8-methoxyfluoroquinolone antibacterial agent for oral or intravenous administration. Chemically, gatifloxacin is ()-1-cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid sesquihydrate.

The chemical structure is:

Its empirical formula is C19H22FN3O41.5 H2O and its molecular weight is 402.42. Gatifloxacin is a sesquihydrate crystalline powder and is white to pale yellow in color. It exists as a racemate, with no net optical rotation. The solubility of the compound is pH dependent. The maximum aqueous solubility (40-60 mg/mL) occurs at a pH range of 2 to 5.

TEQUIN (gatifloxacin removed from us market - may 2006) Tablets

TEQUIN (gatifloxacin removed from us market - may 2006) Tablets are available as 200-mg and 400-mg white, film-coated tablets and contain the following inactive ingredients: hypromellose, magnesium stearate, methylcellulose, microcrystalline cellulose, polyethylene glycol, polysorbate 80, simethicone, sodium starch glycolate, sorbic acid, and titanium dioxide.

TEQUIN (gatifloxacin removed from us market - may 2006) Injection for Intravenous Administration

TEQUIN (gatifloxacin removed from us market - may 2006) Injection is available in 40-mL (400-mg) single-use vials as a sterile, preservative-free aqueous solution of gatifloxacin with pH ranging from 3.5 to 5.5. TEQUIN (gatifloxacin in 5% dextrose) Injection is also available in ready-to-use 100-mL (200-mg) and 200-mL (400-mg) flexible bags as a sterile, preservative-free aqueous solution of gatifloxacin with pH ranging from 3.5 to 5.5. The appearance of the intravenous solution may range from light yellow to greenish-yellow in color. The color does not affect nor is it indicative of product stability.

The intravenous formulation contains dextrose, anhydrous, USP or dextrose, monohydrate, USP and Water for Injection, USP, and may contain hydrochloric acid and/or sodium hydroxide for pH adjustment.

What are the possible side effects of gatifloxacin (Tequin, Tequin Teqpaq)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using gatifloxacin and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeats;
  • feeling light-headed, fainting;
  • seizure (convulsions);
  • numbness, tingly feeling, burning pain;
  • skin rash that is red and blisters or peels;
  • diarrhea that is...

Read All Potential Side Effects and See Pictures of Tequin

What are the precautions when taking gatifloxacin (removed from us market - may 2006) (Tequin)?

Consult your...

Read All Potential Precautions of Tequin


Tequin Consumer (continued)

SIDE EFFECTS: Consult your pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Consult your pharmacist.


Tequin Patient Information Including Side Effects

Brand Names: Tequin, Tequin Teqpaq

Generic Name: gatifloxacin (Pronunciation: gah the FLOCK sah sin)

  • What is gatifloxacin (Tequin)?
  • What are the possible side effects of gatifloxacin (Tequin)?
  • What is the most important information I should know about gatifloxacin (Tequin)?
  • What should I discuss with my healthcare provider before taking gatifloxacin (Tequin)?
  • How should I take gatifloxacin (Tequin)?
  • What happens if I miss a dose (Tequin)?
  • What happens if I overdose (Tequin)?
  • What should I avoid while taking gatifloxacin (Tequin)?
  • What other drugs will affect gatifloxacin (Tequin)?
  • Where can I get more information?

What is gatifloxacin (Tequin)?

Gatifloxacin is an antibiotic in a group of drugs called fluoroquinolones. It fights bacteria in the body.

Gatifloxacin is used to treat bacterial infections of the lungs, sinuses, skin, and urinary tract. It is also used to treat certain sexually transmitted diseases.

Gatifloxacin may also be used for purposes other than those listed here.

What are the possible side effects of gatifloxacin (Tequin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using gatifloxacin and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeats;
  • feeling light-headed, fainting;
  • seizure (convulsions);
  • numbness, tingly feeling, burning pain;
  • skin rash that is red and blisters or peels;
  • diarrhea that is watery or bloody;
  • nausea, stomach pain, low fever, lost appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • sudden pain or swelling near your joints (especially in your arm or ankle); or
  • a skin rash.

Continue using gatifloxacin and talk with your doctor if you have any of these less serious side effects:

  • mild nausea, vomiting, stomach pain, diarrhea;
  • feeling dizzy, restless, or confused;
  • vaginal discharge or itching;
  • sleep problems (insomnia or nightmares); or
  • headache.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about gatifloxacin (Tequin)?

You should not take gatifloxacin if you have diabetes.

Before taking gatifloxacin, tell your doctor if you have a personal or family history of "Long QT syndrome" or other heart rhythm disorder, especially if you are being treated with one of these medications: quinidine (Cardioquin, Quinidex, Quinaglute), disopyramide (Norpace), bretylium (Bretylol), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), or sotalol (Betapace).

If you take any of the following medicines, take them at least 4 hours after you take gatifloxacin: an antacid that contains magnesium or aluminum; vitamin or mineral supplements that contain zinc, magnesium or iron; or didanosine chewable/buffered tablets or pediatric powder for oral solution (ddI, Videx, Videx Pediatric).

There are many other drugs that can affect gatifloxacin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Take this medication for as many days as it has been prescribed for you even if you begin to feel better. Your symptoms may get better before the infection is completely treated. Gatifloxacin will not treat a viral infection such as the common cold or flu.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Gatifloxacin can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. Call your doctor if you have severe sunburn, redness, itching, rash, or swelling after exposure to the sun.

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