Thorazine

DRUG DESCRIPTION

Thorazine (chlorpromazine) is 10-(3-dimethylaminopropyl)-2-chlorphenothiazine, a dimethylamine derivative of phenothiazine. It is present in oral and injectable forms as the hydrochloride salt, and in the suppositories as the base.

THORAZINE® (chlorpromazine)   Structural Formula Illustration

Tablets — Each round, orange, coated tablet contains chlorpromazine hydrochloride as follows: 10 mg imprinted SKF and T73; 25 mg imprinted SKF and T74; 50 mg imprinted SKF and T76; 100 mg imprinted SKF and T77; 200 mg imprinted SKF and T79. Inactive ingredients consist of benzoic acid, croscarmellose sodium, D&C Yellow No. 10, FD&C Blue No. 2, FD&C Yellow No. 6, gelatin, hydroxypropyl methylcellulose, lactose, magnesium stearate, methylparaben, polyethylene glycol, propylparaben, talc, titanium dioxide and trace amounts of other inactive ingredients.

Spansule® sustained release capsules — Each Thorazine (chlorpromazine) Spansule® capsule is so prepared that an initial dose is released promptly and the remaining medication is released gradually over a prolonged period.

Each capsule, with opaque orange cap and natural body, contains chlorpromazine hydrochloride as follows: 30 mg imprinted SKF and T63; 75 mg imprinted SKF and T64; 150 mg imprinted SKF and T66. Inactive ingredients consist of benzyl alcohol, calcium sulfate, cetylpyridinium chloride, FD&C Yellow No. 6, gelatin, glyceryl distearate, glyceryl monostearate, iron oxide, povidone, silicon dioxide, sodium lauryl sulfate, starch, sucrose, titanium dioxide, wax and trace amounts of other inactive ingredients.

Ampuls — Each mL contains, in aqueous solution, chlorpromazine hydrochloride, 25 mg; ascorbic acid, 2 mg; sodium bisulfite, 1 mg; sodium chloride, 6 mg; sodium sulfite, 1 mg.

Multi-Dose Vials — Each mL contains, in aqueous solution, chlorpromazine hydrochloride, 25 mg; ascorbic acid, 2 mg; sodium bisulfite, 1 mg; sodium chloride, 1 mg; sodium sulfite, 1 mg; benzyl alcohol, 2%, as a preservative.

Syrup — Each 5 mL (1 teaspoonful) of clear, orange-custard flavored liquid contains chlorpromazine hydrochloride, 10 mg. Inactive ingredients consist of citric acid, flavors, sodium benzoate, sodium citrate, sucrose and water.

Suppositories — Each suppository contains chlorpromazine, 25 or 100 mg, glycerin, glyceryl monopalmitate, glyceryl monostearate, hydrogenated coconut oil fatty acids and hydrogenated palm kernel oil fatty acids.

What are the possible side effects of chlorpromazine (Thorazine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking chlorpromazine and call your doctor at once if you have a serious side effect such as:

  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • feeling...

Read All Potential Side Effects and See Pictures of Thorazine »


Thorazine Patient Information Including Side Effects

Brand Names: Thorazine

Generic Name: chlorpromazine (oral) (Pronunciation: klor PROE ma zeen)

  • What is chlorpromazine (Thorazine)?
  • What are the possible side effects of chlorpromazine (Thorazine)?
  • What is the most important information I should know about chlorpromazine (Thorazine)?
  • What should I discuss with my healthcare provider before taking chlorpromazine (Thorazine)?
  • How should I take chlorpromazine (Thorazine)?
  • What happens if I miss a dose (Thorazine)?
  • What happens if I overdose (Thorazine)?
  • What should I avoid while taking chlorpromazine (Thorazine)?
  • What other drugs will affect chlorpromazine (Thorazine)?
  • Where can I get more information?

What is chlorpromazine (Thorazine)?

Chlorpromazine is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Chlorpromazine is used to treat psychotic disorders such as schizophrenia or manic-depression, and severe behavioral problems in children. It is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.

Chlorpromazine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of chlorpromazine (Thorazine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking chlorpromazine and call your doctor at once if you have a serious side effect such as:

  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • feeling like you might pass out;
  • seizure (black-out or convulsions);
  • nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);
  • pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;
  • high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;
  • unusual thoughts or behavior;
  • decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;
  • urinating less than usual or not at all;
  • joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious side effects may include:

  • dizziness, drowsiness, anxiety, sleep problems (insomnia);
  • breast swelling or discharge;
  • changes in menstrual periods;
  • weight gain, swelling in your hands or feet;
  • dry mouth or stuffy nose, blurred vision;
  • constipation; or
  • impotence, trouble having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about chlorpromazine (Thorazine)?

Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

Chlorpromazine is not for use in psychotic conditions related to dementia. Chlorpromazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Do not use chlorpromazine if you have brain damage, bone marrow depression, or are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to chlorpromazine or other phenothiazines.

Before you take chlorpromazine, tell your doctor if you have liver or kidney disease, heart disease or high blood pressure, glaucoma, severe breathing problems, past or present breast cancer, low levels of calcium in your blood, adrenal gland tumor, enlarged prostate or urination problems, a history of seizures, Parkinson's disease, or if you have ever had a serious side effect while using chlorpromazine or similar medicines.

Before taking chlorpromazine, tell your doctor about all other medications you use.

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