Hytrin

DRUG DESCRIPTION

HYTRIN (terazosin hydrochloride), an alpha-1-selective adrenoceptor blocking agent, is a quinazoline derivative represented by the following chemical name and structural formula:

(RS)-Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetra-hydro-2-furanyl)carbonyl]-, monohydrochloride, dihydrate.

HYTRIN®
  (terazosin hydrochloride)  Structural Formula Illustration

Terazosin hydrochloride is a white, crystalline substance, freely soluble in water and isotonic saline and has a molecular weight of 459.93. HYTRIN tablets (terazosin hydrochloride tablets) for oral ingestion are supplied in four dosage strengths containing terazosin hydrochloride equivalent to 1 mg, 2 mg, 5 mg, or 10 mg of terazosin.

Inactive Ingredients

1 mg tablet: corn starch, lactose, magnesium stearate, povidone and talc.

2 mg tablet: corn starch, FD&C Yellow No. 6, lactose, magnesium stearate, povidone and talc.

5 mg tablet: corn starch, iron oxide, lactose, magnesium stearate, povidone and talc.

10 mg tablet: corn starch, D&C Yellow No. 10, FD&C Blue No. 2, lactose, magnesium stearate, povidone and talc.

What are the possible side effects of terazosin (Hytrin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fast or pounding heartbeats;
  • feeling light-headed, fainting;
  • swelling in your hands, ankles, or feet; or
  • penis erection that is painful or lasts 4 hours or longer.

Less serious side effects may include:

  • weakness;
  • ...

Read All Potential Side Effects and See Pictures of Hytrin »

What are the precautions when taking terazosin hcl (Hytrin)?

Before taking terazosin, tell your doctor or pharmacist if you are allergic to it; or to other alpha-blockers (e.g., doxazosin, prazosin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure/fainting, prostate cancer, other prostate/bladder problems, liver disease.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. You should avoid driving or hazardous tasks for 12 hours after the first dose, after your dose is...

Read All Potential Precautions of Hytrin »


Hytrin Consumer (continued)

SIDE EFFECTS: Fatigue, nausea, drowsiness, blurred vision, headache, or stuffy nose may occur. Lightheadedness or dizziness upon standing may also occur, especially after the first dose, and shortly after taking the drug during the first week of treatment. To minimize dizziness and the risk of fainting, get up slowly when rising from a seated or lying position. If dizziness occurs, sit or lie down. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: fainting, fast/irregular heartbeat, burning/tingling in the hands/feet, sexual function problems, swelling of the ankles/hands/feet, unexpected weight gain.

Tell your doctor immediately if any of these rare but serious side effects occur: easy bruising/bleeding, mental/mood changes.

For males, in the very unlikely event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and seek immediate medical attention, or permanent problems could occur.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking terazosin, tell your doctor or pharmacist if you are allergic to it; or to other alpha-blockers (e.g., doxazosin, prazosin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure/fainting, prostate cancer, other prostate/bladder problems, liver disease.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. You should avoid driving or hazardous tasks for 12 hours after the first dose, after your dose is increased, and when this medication is restarted after it has been stopped. Limit alcoholic beverages.

To reduce the risk of dizziness and fainting, caution is advised when standing for long periods. Avoid getting overheated during exercise or hot weather. If dizziness occurs, sit or lie down.

Before having surgery (including cataract eye surgery), tell your doctor or dentist that you are taking this medication.

Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially dizziness and fainting.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Hytrin Patient Information Including Side Effects

Brand Names: Hytrin

Generic Name: terazosin (Pronunciation: ter AY zo sin)

  • What is terazosin (Hytrin)?
  • What are the possible side effects of terazosin (Hytrin)?
  • What is the most important information I should know about terazosin (Hytrin)?
  • What should I discuss with my healthcare provider before taking terazosin (Hytrin)?
  • How should I take terazosin (Hytrin)?
  • What happens if I miss a dose (Hytrin)?
  • What happens if I overdose (Hytrin)?
  • What should I avoid while taking terazosin (Hytrin)?
  • What other drugs will affect terazosin (Hytrin)?
  • Where can I get more information?

What is terazosin (Hytrin)?

Terazosin is in a group of drugs called alpha-adrenergic blockers. Terazosin causes the blood vessels (veins and arteries) to relax and expand, improving blood flow. Terazosin also relaxes muscles in the prostate and bladder neck, making it easier to urinate.

Terazosin is used to treat hypertension (high blood pressure) and benign prostatic hyperplasia (enlarged prostate).

Terazosin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of terazosin (Hytrin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fast or pounding heartbeats;
  • feeling light-headed, fainting;
  • swelling in your hands, ankles, or feet; or
  • penis erection that is painful or lasts 4 hours or longer.

Less serious side effects may include:

  • weakness;
  • headache;
  • numbness or tingly feeling;
  • stuffy nose; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about terazosin (Hytrin)?

You should not use this medication if you are allergic to terazosin.

Before taking terazosin, tell your doctor if you use any other blood pressure medications, especially verapamil (Calan, Covera, Isoptin, Verelan).

Terazosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it, or when you start taking it again. To avoid falling, take the first dose of terazosin at bedtime. You may wish to continue taking this medication only at bedtime if it causes you to feel light-headed.

You may feel very dizzy when you first wake up. Be careful when standing or sitting up from a lying position.

If you stopped taking terazosin for any reason and have started taking it again, you may feel especially dizzy or light-headed after your first few doses.

Terazosin can affect the pupils of your eyes during cataract surgery. If you have cataract surgery during your treatment with terazosin, tell the surgeon ahead of time that you take terazosin. Do not stop using the medication before surgery unless your surgeon tells you to.

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