Trental

DRUG DESCRIPTION

TRENTAL® (pentoxifylline) tablets for oral administration contain 400 mg of the active drug and the following inactive ingredients: FD&C Red No. 3, hypromellose USP, magnesium stearate NF, polyethylene glycol NF, povidone USP, talc USP, titanium dioxide USP, and hydroxyethyl cellulose USP in an extended-release formulation. TRENTAL (pentoxifylline) is a tri-substituted xanthine derivative designated chemically as 1-(5-oxohexyl)-3, 7-dimethylxanthine that, unlike theophylline, is a hemorrheologic agent, i.e. an agent that affects blood viscosity. Pentoxifylline is soluble in water and ethanol, and sparingly soluble in toluene. The CAS Registry Number is 6493-05-6.

The chemical structure is:

TRENTAL® 
  (pentoxifylline)  Structural Formula Illustration

What are the possible side effects of pentoxifylline (Pentoxil, Trental)?

If you experience any of the following serious side effects, stop taking pentoxifylline and seek medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • chest pain or an irregular heartbeat;
  • severe dizziness, headache, nosebleeds, or blurred vision;
  • nausea or vomiting; or
  • swollen feet or ankles.

Other, less serious side effects may be more likely to occur. Continue to take...

Read All Potential Side Effects and See Pictures of Trental »

What are the precautions when taking pentoxifylline (Trental)?

Before taking pentoxifylline, tell your doctor or pharmacist if you are allergic to it; or to caffeine, or theophylline; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: recent stroke, recent bleeding in the eye, kidney problems, recent major surgery, stomach ulcer.

This drug may rarely make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use...

Read All Potential Precautions of Trental »


Trental Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, gas, belching, and dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but very serious side effects occur: fast/irregular heartbeat, easy bruising/bleeding.

Seek immediate medical attention if this rare but very serious side effect occurs: chest pain.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking pentoxifylline, tell your doctor or pharmacist if you are allergic to it; or to caffeine, or theophylline; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: recent stroke, recent bleeding in the eye, kidney problems, recent major surgery, stomach ulcer.

This drug may rarely make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.


Trental Patient Information Including Side Effects

Brand Names: Pentoxil, Trental

Generic Name: pentoxifylline (Pronunciation: pen tox I fi leen)

  • What is pentoxifylline (Trental)?
  • What are the possible side effects of pentoxifylline (Trental)?
  • What is the most important information I should know about pentoxifylline (Trental)?
  • What should I discuss with my healthcare provider before taking pentoxifylline (Trental)?
  • How should I take pentoxifylline (Trental)?
  • What happens if I miss a dose (Trental)?
  • What happens if I overdose (Trental)?
  • What should I avoid while taking pentoxifylline (Trental)?
  • What other drugs will affect pentoxifylline (Trental)?
  • Where can I get more information?

What is pentoxifylline (Trental)?

Pentoxifylline changes the shape of red blood cells in your blood. This makes it easier for these blood cells to fit into small arteries (blood vessels).

Pentoxifylline is used to improve blood flow. Improved blood flow helps to reduce leg cramps and other symptoms of vascular disease (disease related to veins and arteries).

Pentoxifylline may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of pentoxifylline (Trental)?

If you experience any of the following serious side effects, stop taking pentoxifylline and seek medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • chest pain or an irregular heartbeat;
  • severe dizziness, headache, nosebleeds, or blurred vision;
  • nausea or vomiting; or
  • swollen feet or ankles.

Other, less serious side effects may be more likely to occur. Continue to take pentoxifylline and talk to your doctor if you experience

  • insomnia,
  • red eyes, or
  • nervousness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pentoxifylline (Trental)?

Do not break, crush, or chew the tablets. Swallow them whole. They are specially coated to protect your stomach.

Do not stop taking this medication suddenly. It may take up to 8 weeks for you to see beneficial effects from pentoxifylline.

Tobacco may worsen your condition or decrease the beneficial effects of pentoxifylline by narrowing your blood vessels. Talk to your doctor or pharmacist if you have a tobacco habit.

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