Taclonex Scalp

DRUG DESCRIPTION

Taclonex Scalp® (calcipotriene and betamethasone dipropionate topical suspension) Topical Suspension contains calcipotriene hydrate and betamethasone dipropionate. It is intended for topical use on the scalp.

Calcipotriene hydrate is a synthetic vitamin D3 analogue.

Chemically, calcipotriene hydrate is 9,10-Secochola-5,7,10(19),22- tetraene-1,3,24- triol,24-cyclo-propyl-, monohydrate, (1?,3?,5Z,7E,22E,24S) with the empirical formula C27H40O3,H2O, a molecular weight of 430.6, and the following structural formula:

Calcipotriene hydrate structural formula illustration

Calcipotriene hydrate is a white to almost white, crystalline compound.

Betamethasone dipropionate is a synthetic corticosteroid.

Betamethasone dipropionate has the chemical name Pregna-1,4- diene-3,20-dione-9- fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxypropoxy)-(11?,16?), with the empirical formula C28H37FO7, a molecular weight of 504.6, and the following structural formula:

Betamethasone dipropionate structural formula illustration

Betamethasone dipropionate is a white to almost white, crystalline powder.

Each gram of Taclonex Scalp® (calcipotriene and betamethasone dipropionate topical suspension) Topical Suspension contains 52.18 mcg of calcipotriene hydrate (equivalent to 50 mcg of calcipotriene) and 0.643 mg of betamethasone dipropionate (equivalent to 0.5 mg of betamethasone) in a base of hydrogenated castor oil, PPG-15 stearyl ether and mineral oil.

What are the possible side effects of betamethasone and calcipotriene (Taclonex, Taclonex Scalp)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using betamethasone and calcipotriene and call your doctor at once if you have any of these serious side effects:

  • severe skin irritation on treated areas;
  • worsened symptoms or no improvement in psoriasis;
  • pus, swelling, redness, increased itching, or other signs of skin infection;
  • confusion,...

Read All Potential Side Effects and See Pictures of Taclonex Scalp »

What are the precautions when taking calcipotriene and betamethasone dipropionate topical suspension (Taclonex Scalp)?

Before using this medication, tell your doctor or pharmacist if you are allergic to betamethasone or calcipotriene; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor your medical history, especially of: a certain mineral imbalance (high calcium levels in the blood or urine), thin skin in the area to be treated, liver disease.

If you have a skin infection (such as chickenpox, herpes simplex) or a skin problem other than psoriasis, it should be treated before you start this medication. Betamethasone and other corticosteroid drugs can slow down your body's response to antibiotic drugs and make it more...

Read All Potential Precautions of Taclonex Scalp »


Taclonex Scalp Consumer (continued)

SIDE EFFECTS: Itching, burning, redness, or irritation of the skin may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: skin thinning/discoloration/"stretch marks", swelling/inflammation of the hair pores (folliculitis), worsening of psoriasis.

This medication may infrequently cause an increase in the level of calcium in your blood or urine. Tell your doctor immediately if you notice any of the following unlikely but serious side effects: mental/mood changes, unexplained constipation, pink/bloody urine, painful urination.

Rarely, it is possible this medication will be absorbed from the skin into the bloodstream. This can lead to side effects of too much corticosteroid. These side effects are more likely in children, and in people who use this medication for a long time or over large areas of the skin. Tell your doctor right away if any of the following side effects occur: unusual/extreme tiredness, weight loss, headache, swelling ankles/feet, increased thirst/urination, vision problems.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to betamethasone or calcipotriene; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor your medical history, especially of: a certain mineral imbalance (high calcium levels in the blood or urine), thin skin in the area to be treated, liver disease.

If you have a skin infection (such as chickenpox, herpes simplex) or a skin problem other than psoriasis, it should be treated before you start this medication. Betamethasone and other corticosteroid drugs can slow down your body's response to antibiotic drugs and make it more difficult to clear an infection.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors. Your doctor may direct you to limit or avoid phototherapy while you use this product. Discuss this further with your doctor.

Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.

Though it is unlikely, this medication may slow down a child's growth if used for a long time. The effect on final adult height is unknown. See the doctor regularly so your child's height can be checked.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk when applied to the skin. Consult your doctor before breast-feeding.


Taclonex Scalp Patient Information Including Side Effects

Brand Names: Taclonex, Taclonex Scalp

Generic Name: betamethasone and calcipotriene (topical) (Pronunciation: BAY ta METH a sone and KAL si poe TRYE een)

  • What is betamethasone and calcipotriene (Taclonex Scalp)?
  • What are the possible side effects of betamethasone and calcipotriene (Taclonex Scalp)?
  • What is the most important information I should know about betamethasone and calcipotriene (Taclonex Scalp)?
  • What should I discuss with my healthcare provider before using betamethasone and calcipotriene (Taclonex Scalp)?
  • How should I use betamethasone and calcipotriene (Taclonex Scalp)?
  • What happens if I miss a dose (Taclonex Scalp)?
  • What happens if I overdose (Taclonex Scalp)?
  • What should I avoid while using betamethasone and calcipotriene (Taclonex Scalp)?
  • What other drugs will affect betamethasone and calcipotriene (Taclonex Scalp)?
  • Where can I get more information?

What is betamethasone and calcipotriene (Taclonex Scalp)?

Betamethasone is a topical corticosteroid. It reduces swelling, relieves itching, and constricts blood vessels.

Calcipotriene is a form of vitamin D. It works by decreasing the rate of skin cell reproduction.

Betamethasone and calcipotriene is a combination drug used to treat psoriasis vulgaris.

Betamethasone and calcipotriene may also be used for other purposes not listed in this medication guide.

What are the possible side effects of betamethasone and calcipotriene (Taclonex Scalp)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using betamethasone and calcipotriene and call your doctor at once if you have any of these serious side effects:

  • severe skin irritation on treated areas;
  • worsened symptoms or no improvement in psoriasis;
  • pus, swelling, redness, increased itching, or other signs of skin infection;
  • confusion, thirst, extreme tiredness, lost appetite, weight loss;
  • adrenal insufficiency--nausea, vomiting, lost appetite, tiredness, trouble breathing, joint/muscle pain, feeling light-headed, fainting;
  • Cushing syndrome--weight gain (especially in your face), thinning muscles in your arms or legs, easy bruising, thinning skin, acne, increased facial hair, darkened skin; or
  • high blood sugar (hyperglycemia)--increased urination and thirst, nausea, vomiting.

Less serious side effects may include:

  • burning or mild itching;
  • red or scaly rash;
  • swollen hair follicles; or
  • changes in the color of treated skin areas.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about betamethasone and calcipotriene (Taclonex Scalp)?

Use this medication exactly as it was prescribed for you. Do not use it in larger doses or for longer than recommended by your doctor.

Before using betamethasone and calcipotriene, tell your doctor if you are pregnant or breast-feeding.

If you miss a dose, use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

There may be other drugs that can affect betamethasone and calcipotriene. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Stop using this medication and get emergency medical help if you think you have used too much medicine, or if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects are more likely, and you may have none at all. Talk to your doctor about any side effect that seems unusual or is especially bothersome.

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