Transderm Nitro

DRUG DESCRIPTION

Nitroglycerin is 1,2,3-propanetriol, trinitrate, an organic nitrate whose structural formula is

 Transderm-Nitro® (nitroglycerin)  Structural Formula Illustration

and whose molecular weight is 227.09. The organic nitrates are vasodilators, active on both arteries and veins.

The Transderm-Nitro (nitroglycerin) transdermal system is a flat unit designed to provide continuous controlled release of nitroglycerin through intact skin.

The rate of release of nitroglycerin is linearly dependent upon the area of the applied system; each cm? of applied system delivers approximately 0.02 mg of nitroglycerin per hour. Thus, the 5-, 10-, 20-, and 30-cm? systems deliver approximately 0.1, 0.2, 0.4, and 0.6 mg of nitroglycerin per hour, respectively.

The remainder of the nitroglycerin in each system serves as a reservoir and is not delivered in normal use. After 12 hours, for example, each system has delivered 10% of its original content of nitroglycerin.

The Transderm-Nitro system comprises four layers as shown below. Proceeding from the visible surface towards the surface attached to the skin, these layers are: 1) a tan-colored backing layer (aluminized plastic) that is impermeable to nitroglycerin; 2) a drug reservoir containing nitroglycerin adsorbed on lactose, colloidal silicon dioxide, and silicone medical fluid; 3) an ethylene-vinyl acetate copolymer membrane that is permeable to nitroglycerin; and 4) a layer of hypoallergenic silicone adhesive. Prior to use, a protective peel strip is removed from the adhesive surface.

Cross section of the system

Cross section of the system - Illustration

What are the possible side effects of nitroglycerin transdermal (Minitran, Nitrek, Nitro TD Patch-A, Nitro-Dur)?

Nitroglycerin transdermal can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use nitroglycerin transdermal. Do not stop using the medication. Ask your doctor before using any headache pain medication.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a...

Read All Potential Side Effects and See Pictures of Transderm Nitro »

What are the precautions when taking nitroglycerin (Transderm Nitro)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide mononitrate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have a certain medical condition. Before using this medicine, consult your doctor or pharmacist if you have: recent head injury.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: anemia, low blood pressure, loss of too much body water (dehydration), other heart problems (such as recent heart attack).

This drug may make you dizzy. Do not drive, use machinery, or...

Read All Potential Precautions of Transderm Nitro »


Transderm Nitro Consumer (continued)

SIDE EFFECTS: Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to this medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Headache is often a sign that this medication is working. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). If the headaches continue or become severe, tell your doctor promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: fainting, fast/irregular/pounding heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide mononitrate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have a certain medical condition. Before using this medicine, consult your doctor or pharmacist if you have: recent head injury.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: anemia, low blood pressure, loss of too much body water (dehydration), other heart problems (such as recent heart attack).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist that you are using this medication.

If you are going to have an MRI test, tell testing personnel that you are using this patch. Serious burns may occur during an MRI because of the aluminum in some brands of these patches. Consult your doctor for specific instructions on removing the patch before the MRI.

Older adults may be more sensitive to the side effects of this medication, especially dizziness and lightheadedness, which could increase the risk of falls.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk or if it may harm a nursing infant. Consult your doctor before breast-feeding.


Transderm Nitro Patient Information Including Side Effects

Brand Names: Minitran, Nitrek, Nitro TD Patch-A, Nitro-Dur

Generic Name: nitroglycerin (transdermal) (Pronunciation: NYE troe GLIS er in)

  • What is nitroglycerin transdermal (Transderm Nitro)?
  • What are the possible side effects of nitroglycerin transdermal (Transderm Nitro)?
  • What is the most important information I should know about nitroglycerin transdermal (Transderm Nitro)?
  • What should I discuss with my healthcare provider before using nitroglycerin transdermal (Transderm Nitro)?
  • How should I use nitroglycerin transdermal (Transderm Nitro)?
  • What happens if I miss a dose (Transderm Nitro)?
  • What happens if I overdose (Transderm Nitro)?
  • What should I avoid while using nitroglycerin transdermal (Transderm Nitro)?
  • What other drugs will affect nitroglycerin transdermal (Transderm Nitro)?
  • Where can I get more information?

What is nitroglycerin transdermal (Transderm Nitro)?

Nitroglycerin is in a group of drugs called nitrates. Nitroglycerin dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

Nitroglycerin transdermal is used to prevent attacks of chest pain (angina).

Nitroglycerin transdermal may also be used for other purposes not listed in this medication guide.

What are the possible side effects of nitroglycerin transdermal (Transderm Nitro)?

Nitroglycerin transdermal can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use nitroglycerin transdermal. Do not stop using the medication. Ask your doctor before using any headache pain medication.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • worsening chest pain, slow heart rate;
  • feeling like you might pass out;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • fast or pounding heartbeats; or
  • blurred vision and dry mouth.

Less serious side effects may include:

  • mild skin rash or itching;
  • warmth, redness, or tingly feeling under your skin;
  • nausea, vomiting, upset stomach; or
  • feeling nervous, weak, or dizzy.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about nitroglycerin transdermal (Transderm Nitro)?

You should not use this medication if you are allergic to nitroglycerin, isosorbide mononitrate (Imdur), or isosorbide dinitrate (BiDil, Isordil).

Before using nitroglycerin transdermal, tell your doctor if you have congestive heart failure, low blood pressure, glaucoma, anemia, or a history of heart attack, stroke, or head injury.

Do not use this medication to treat an angina attack that has already begun. It will not work fast enough.

Nitroglycerin transdermal can cause severe headaches, especially when you first start using it. Do not stop using the skin patches, and ask your doctor before using any headache pain medication.

Nitroglycerin transdermal can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol. It can increase some of the side effects of nitroglycerin transdermal.

Call your doctor at once if you have a serious side effect such as worsening chest pain, pain spreading to the arm or shoulder, nausea, vomiting, sweating, blurred vision and dry mouth, or fainting.

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