Trimethoprim

DRUG DESCRIPTION

Trimethoprim (trimethoprim (trimethoprim tablet) tablet) is a synthetic antibacterial available as 100 mg tablets for oral administration.

Trimethoprim (trimethoprim (trimethoprim tablet) tablet) is 2,4-Diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine. It is a white to cream colored, odorless, bitter compound. The structural formula is represented below:

Trimethoprim Structural Formula Illustration

Trimethoprim (trimethoprim (trimethoprim tablet) tablet) Tablets USP, 100 mg contain the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, magnesium stearate, sodium lauryl sulfate, sodium starch glycolate and stearic acid.

What are the precautions when taking trimethoprim tablet (Trimethoprim)?

Before taking trimethoprim, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have a certain medical condition. Before using this medicine, consult your doctor or pharmacist if you have: a certain type of anemia (due to folate deficiency).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, vitamin deficiency (folate or folic acid), diabetes, blood disorders (e.g., bone marrow suppression, G6PD deficiency).

This medication may make you more sensitive to the sun....

Read All Potential Precautions of Trimethoprim


Trimethoprim Consumer (continued)

SIDE EFFECTS: Diarrhea, nausea, vomiting, stomach upset, loss of appetite, changes in taste, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but very serious side effects occur: swollen tongue, signs of infection (e.g., fever, persistent sore throat), easy bruising/bleeding, unusual paleness, mental/mood changes, tiredness with fast/pounding/irregular heartbeat, dark urine, persistent nausea/vomiting, stomach/abdominal pain, yellowing eyes/skin, stiff neck, persistent headache, muscle weakness.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking trimethoprim, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have a certain medical condition. Before using this medicine, consult your doctor or pharmacist if you have: a certain type of anemia (due to folate deficiency).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, vitamin deficiency (folate or folic acid), diabetes, blood disorders (e.g., bone marrow suppression, G6PD deficiency).

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for mineral imbalance (high potassium blood level) and allergic reactions while using this drug.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

Trimethoprim passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.



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