Tabloid

DRUG DESCRIPTION

TABLOID brand Thioguanine was synthesized and developed by Hitchings, Elion, and associates at the Wellcome Research Laboratories. It is one of a large series of purine analogues which interfere with nucleic acid biosynthesis, and has been found active against selected human neoplastic diseases.

Thioguanine, known chemically as 2-amino-1,7-dihydro-6H-purine-6-thione, is an analogue of the nucleic acid constituent guanine, and is closely related structurally and functionally to PURINETHOL® (mercaptopurine). Its structural formula is:

TABLOID® brand Thioguanine Structural Formula Illustration

TABLOID brand Thioguanine is available in tablets for oral administration. Each scored tablet contains 40 mg thioguanine and the inactive ingredients gum acacia, lactose, magnesium stearate, potato starch, and stearic acid.

What are the possible side effects of thioguanine ()?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (shortness of breath; closing of the throat; difficulty breathing; swelling of the lips, face, or tongue; or hives);
  • abdominal pain;
  • jaundice (yellowing of the skin or eyes);
  • extreme fatigue;
  • signs of infection such as fever; chills, or sore throat;
  • unusual bleeding or bruising;
  • black, bloody or tarry stools; or
  • ...

Read All Potential Side Effects and See Pictures of Tabloid »

What are the precautions when taking thioguanine (Tabloid)?

Before taking thioguanine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medicine, consult your doctor or pharmacist if a certain drug (mercaptopurine) did not work for you in the past. This may affect how well thioguanine works for you.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other blood disorders (e.g., anemia, low blood cell counts), gout, kidney stones, liver disease.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received...

Read All Potential Precautions of Tabloid »


Tabloid Consumer (continued)

SIDE EFFECTS: Upset stomach, nausea, vomiting, and diarrhea may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: easy bruising/bleeding, dizziness/fainting, joint pain/swelling, persistent nausea/vomiting, stomach/abdominal pain, tongue/mouth sores or pain, unusual tiredness, dark urine, yellowing eyes/skin.

This medication can lower the body's ability to fight an infection. Tell your doctor promptly if you develop any signs of an infection such as fever, chills, or persistent sore throat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking thioguanine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medicine, consult your doctor or pharmacist if a certain drug (mercaptopurine) did not work for you in the past. This may affect how well thioguanine works for you.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other blood disorders (e.g., anemia, low blood cell counts), gout, kidney stones, liver disease.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.

Wash your hands well to prevent the spread of infections.

To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

If you need to have surgery or a dental procedure, tell your doctor or dentist that you are using thioguanine.

Drinking alcohol may increase the risk of stomach/esophagus irritation or liver damage. Limit alcoholic beverages.

People with a certain inherited problem (lack of thiopurine methyltransferase-TPMT enzyme) may be at increased risk for serious side effects from this medication and may require dosage adjustment. Consult your doctor for details and to discuss whether you should be tested for this inherited problem.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details and to discuss reliable forms of birth control. If you become pregnant or think you may be pregnant, tell your doctor immediately.

It is not known whether this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.


Tabloid Patient Information Including Side Effects

Brand Names:

Generic Name: thioguanine (Pronunciation: thigh oh GUAH neen)

  • What is thioguanine ?
  • What are the possible side effects of thioguanine ?
  • What is the most important information I should know about thioguanine ?
  • What should I discuss with my healthcare provider before taking thioguanine ?
  • How should I take thioguanine ?
  • What happens if I miss a dose ?
  • What happens if I overdose ?
  • What should I avoid while taking thioguanine ?
  • What other drugs will affect thioguanine ?
  • Where can I get more information?

What is thioguanine ?

Thioguanine is a cancer (antineoplastic) medication. Thioguanine interferes with the growth of cancer cells and slows their growth and spread in the body.

Thioguanine is used to treat blood cancer (acute non-lymphocytic leukemia).

Thioguanine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of thioguanine ?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (shortness of breath; closing of the throat; difficulty breathing; swelling of the lips, face, or tongue; or hives);
  • abdominal pain;
  • jaundice (yellowing of the skin or eyes);
  • extreme fatigue;
  • signs of infection such as fever; chills, or sore throat;
  • unusual bleeding or bruising;
  • black, bloody or tarry stools; or
  • severe nausea, vomiting, or diarrhea.

Other less serious side effects may be more likely to occur. Talk to your doctor if you experience

  • loss of appetite;
  • mild to moderate nausea, vomiting, or diarrhea; or
  • mouth sores.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about thioguanine ?

Thioguanine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of thioguanine including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or sore throat); liver problems (yellowing of the skin or eyes, abdominal pain, nausea); severe nausea, vomiting, diarrhea, loss of appetite, or sores in the mouth; and others. Talk to your doctor about the possible side effects from treatment with thioguanine.

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