Typhim

DRUG DESCRIPTION

Typhim Vi, Typhoid Vi Polysaccharide Vaccine, produced by Sanofi Pasteur SA, for intramuscular use, is a sterile solution containing the cell surface Vi polysaccharide extracted from Salmonella enterica serovar Typhi, S typhi Ty2 strain. The organism is grown in a semi-synthetic medium without animal proteins. The capsular polysaccharide is precipitated from the concentrated culture supernatant by the addition of hexadecyltrimethylammonium bromide and the product is purified by differential centrifugation and precipitation. The potency of the purified polysaccharide is assessed by molecular size and O-acetyl content. Phenol, 0.25%, is added as a preservative. The vaccine contains residual polydimethylsiloxane or fatty-acid ester-based antifoam. The vaccine is a clear, colorless solution. Each dose of 0.5 mL is formulated to contain 25 g of purified Vi polysaccharide in a colorless isotonic phosphate buffered saline (pH 7 0.3), 4.150 mg of Sodium Chloride, 0.065 mg of Disodium Phosphate, 0.023 mg of Monosodium Phosphate and 0.5 mL of Sterile Water for Injection.

What are the possible side effects of typhoid vaccine (Typhim VI)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with typhoid is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely...

Read All Potential Side Effects and See Pictures of Typhim

What are the precautions when taking typhoid vi polysaccharide vaccine (Typhim)?

Before receiving this medication, tell your doctor or pharmacist if you are allergic to it; or to other vaccines; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: bleeding/clotting disorders (e.g., thrombocytopenia), immune system problems (e.g., HIV infection, leukemia), radiation treatment, current fever/illness.

During pregnancy, this vaccine should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this drug passes into breast milk. Consult your doctor before...

Read All Potential Precautions of Typhim


Typhim Consumer (continued)

SIDE EFFECTS: Redness, tenderness, hardening skin, and pain at the injection site may occur. Headache or muscle pain may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Contact your doctor for medical advice about side effects. The following numbers do not provide medical advice, but in the US, you may report side effects to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967. In Canada, you may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before receiving this medication, tell your doctor or pharmacist if you are allergic to it; or to other vaccines; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: bleeding/clotting disorders (e.g., thrombocytopenia), immune system problems (e.g., HIV infection, leukemia), radiation treatment, current fever/illness.

During pregnancy, this vaccine should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.


Typhim Patient Information Including Side Effects

Brand Names: Typhim VI

Generic Name: typhoid vaccine (inactivated), injection (Pronunciation: TYE foid vax EEN)

  • What is typhoid vaccine (Typhim)?
  • What are the possible side effects of typhoid vaccine (Typhim)?
  • What is the most important information I should know about typhoid vaccine (Typhim)?
  • What should I discuss with my healthcare provider before receiving typhoid vaccine (Typhim)?
  • How is typhoid vaccine given (Typhim)?
  • What happens if I miss a dose (Typhim)?
  • What happens if I overdose (Typhim)?
  • What should I avoid before or after getting typhoid vaccine (Typhim)?
  • What other drugs will affect typhoid vaccine (Typhim)?
  • Where can I get more information?

What is typhoid vaccine (Typhim)?

Typhoid (also called "typhoid fever") is a serious disease caused by Salmonella typhi bacteria. Typhoid can be fatal if left untreated.

Typhoid can cause high fever, muscle aches, severe headache, weakness, confusion or agitation, loss of appetite, stomach pain, diarrhea or constipation, and rose-colored spots on the skin.

Untreated typhoid infection may lead to kidney failure, or intestinal bleeding caused by perforation (forming of a hole), which can be fatal. If the infection spreads to the gallbladder, the infected person may become a chronic carrier of the bacteria that causes typhoid. A carrier may have no symptoms but is capable of spreading the infection to others.

Typhoid is spread through contact with the stool (bowel movements) of a person infected with the bacteria. This usually occurs by eating food or drinking water that has become contaminated with feces from an infected person. Once in the digestive tract, typhoid infection can spread to the blood and other parts of the body.

Typhoid fever is most common in non-industrialized parts of the world, especially Asia, Africa, and Central or South America. People who travel to those regions are at risk of coming into contact with the disease.

The typhoid vaccine is used to help prevent this disease in adults and children who are at least 2 years old. Although not part of a routine immunization schedule in the U.S., typhoid vaccine is recommended for people who travel to areas where the disease is common.

This vaccine works by exposing you to a small dose of an extract from the bacteria, which causes your body to develop immunity to the disease.

Typhoid vaccine will not treat an active infection that has already developed in the body, and will not prevent any disease caused by bacteria other than Salmonella typhi.

Like any vaccine, the typhoid vaccine may not provide protection from disease in every person.

What are the possible side effects of typhoid vaccine (Typhim)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with typhoid is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever, swollen glands, rash or itching, joint pain, or general ill feeling;
  • tremors or shaking; or
  • feeling like you might pass out.

Less serious side effects include:

  • pain, tenderness, redness, swelling, or a hard lump where the shot was given;
  • low fever;
  • headache;
  • muscle or joint pain;
  • nausea, diarrhea, stomach pain; or
  • weakness.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about typhoid vaccine (Typhim)?

You should not receive this vaccine if you have ever had an allergic reaction to typhoid vaccine in the past.

Typhoid vaccine should not be used in a person who is a typhoid carrier.

Before you receive this vaccine, tell the doctor if you have a bleeding or blood clotting disorder (such as hemophilia), a weak immune system caused by disease or by taking certain medicines, or if you are taking a blood thinner or receiving cancer treatments or radiation.

Like any vaccine, the typhoid vaccine may not provide protection from disease in every person.

In addition to receiving typhoid vaccine, take precautions while traveling such as avoiding raw fruits or vegetables that cannot be peeled, drinks that contain ice, flavored ices that may have been made with contaminated water, unbottled or unboiled water, or any food or beverage purchased from a street vendor.

Keep track of any and all side effects you have after receiving a typhoid vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

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