Travatan Z

DRUG DESCRIPTION

Travoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[l?(Z),2?(lE,3R*),3?,5?]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1 -butenyl]cyclopentyl]-5-heptenoic acid, 1 -methylethylester. It has a molecular formula of C26H35F3O6 and a molecular weight of 500.55. The chemical structure of travoprost is:

TRAVATAN Z
  (travoprost) Structural Formula Illustration

Travoprost is a clear, colorless to slightly yellow oil that is very soluble in acetonitrile, methanol, octanol, and chloroform. It is practically insoluble in water.

TRAVATAN Z (travoprost ophthalmic solution) 0.004% is supplied as sterile, buffered aqueous solution of travoprost with a pH of approximately 5.7 and an osmolality of approximately 290 mOsmol/kg.

TRAVATAN Z contains Active: travoprost 0.04 mg/mL; Inactives: polyoxyl 40 hydrogenated castor oil, sofZia (boric acid, propylene glycol, sorbitol, zinc chloride), sodium hydroxide and/or hydrochloric acid (to adjust pH) and purified water, USP. Preserved in the bottle with an ionic buffered system, sofZia.

What are the possible side effects of travoprost ophthalmic (Travatan, Travatan Z)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using travoprost ophthalmic and call your doctor at once if you have any of these serious side effects:

  • redness, swelling, itching, or pain in or around your eye;
  • oozing or discharge from your eye;
  • increased sensitivity to light;
  • vision changes; or
  • chest pain.

Less serious side...

Read All Potential Side Effects and See Pictures of Travatan Z

What are the precautions when taking travoprost ophthalmic solution (Travatan Z)?

Before using travoprost, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (e.g., bimatoprost, latanoprost); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (e.g., macular edema, iritis, uveitis, lens extraction/aphakia).

If you develop an eye infection or injury, or have eye surgery, check with your doctor about the continued use of your current bottle of travoprost. You may be advised to start using a new bottle.

This drug may...

Read All Potential Precautions of Travatan Z


Travatan Z Consumer (continued)

SIDE EFFECTS: Blurred vision, eye redness/discomfort/itching, feeling as if something is in your eye, dry eyes, tearing, eyelid crusting, increase in eyelash number/length/thickness, darkening of the eyelashes and eyelids, or increased sensitivity to light may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

This medication may slowly (over months to years) cause brown discoloration of the colored portion of the eye (iris). If you are using travoprost in only one eye, only that iris may change color. This color change may be permanent, but the long-term effects are uncertain. Notify your doctor if this occurs and schedule regular eye exams to monitor it.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: vision changes, eye pain, swelling/redness of the eyelids.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using travoprost, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (e.g., bimatoprost, latanoprost); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (e.g., macular edema, iritis, uveitis, lens extraction/aphakia).

If you develop an eye infection or injury, or have eye surgery, check with your doctor about the continued use of your current bottle of travoprost. You may be advised to start using a new bottle.

This drug may cause temporary blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.


Travatan Z Patient Information Including Side Effects

Brand Names: Travatan, Travatan Z

Generic Name: travoprost ophthalmic (Pronunciation: TRA voe prost off THAL mik)

  • What is travoprost ophthalmic (Travatan Z)?
  • What are the possible side effects of travoprost ophthalmic (Travatan Z)?
  • What is the most important information I should know about travoprost ophthalmic (Travatan Z)?
  • What should I discuss with my health care provider before using travoprost ophthalmic (Travatan Z)?
  • How should I use travoprost ophthalmic (Travatan Z)?
  • What happens if I miss a dose (Travatan Z)?
  • What happens if I overdose (Travatan Z)?
  • What should I avoid while using travoprost ophthalmic (Travatan Z)?
  • What other drugs will affect travoprost ophthalmic (Travatan Z)?
  • Where can I get more information?

What is travoprost ophthalmic (Travatan Z)?

Travoprost ophthalmic (for the eye) reduces pressure in the eye by increasing the amount of fluid that drains from the eye.

Travoprost ophthalmic is used to treat certain types of glaucoma and other causes of high pressure inside the eye.

Travoprost ophthalmic may also be used for other purposes not listed in this medication guide.

What are the possible side effects of travoprost ophthalmic (Travatan Z)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using travoprost ophthalmic and call your doctor at once if you have any of these serious side effects:

  • redness, swelling, itching, or pain in or around your eye;
  • oozing or discharge from your eye;
  • increased sensitivity to light;
  • vision changes; or
  • chest pain.

Less serious side effects may include:

  • mild eye discomfort;
  • headache;
  • feeling like something is in your eye;
  • blurred vision;
  • dry or watery eyes; or
  • stinging or burning of the eyes after using the drops.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about travoprost ophthalmic (Travatan Z)?

Travoprost ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, as well as increased growth or thickness of your eyelashes. These color changes, usually an increase in brown pigment, occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

After using this medication, wait at least 5 minutes before using any other eye drops that your doctor has prescribed.

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