Ticlid

DRUG DESCRIPTION

TICLID (ticlopidine hydrochloride) is a platelet aggregation inhibitor. Chemically it is 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c] pyridine hydrochloride. The structural formula is:

TICLID®  (ticlopidine hydrochloride)   Structural Formula Illustration

Ticlopidine hydrochloride is a white crystalline solid. It is freely soluble in water and self-buffers to a pH of 3.6. It also dissolves freely in methanol, is sparingly soluble in methylene chloride and ethanol, slightly soluble in acetone and insoluble in a buffer solution of pH 6.3. It has a molecular weight of 300.25.

TICLID (ticlopidine hcl) tablets for oral administration are provided as white, oval, film-coated, blue-imprinted tablets containing 250 mg of ticlopidine hydrochloride. Each tablet also contains citric acid, magnesium stearate, microcrystalline cellulose, povidone, starch and stearic acid as inactive ingredients. The white film-coating contains hydroxypropylmethyl cellulose, polyethylene glycol and titanium dioxide. Each tablet is printed with blue ink, which includes FD&C Blue #1 aluminum lake as the colorant. The tablets are identified with Ticlid (ticlopidine hcl) on one side and 250 on the reverse side.

What are the possible side effects of ticlopidine (Ticlid)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using ticlopidine and call your doctor at once if you have a serious side effect such as:

  • nosebleed or other bleeding that will not stop;
  • black, bloody, or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill...

Read All Potential Side Effects and See Pictures of Ticlid »

What are the precautions when taking ticlopidine hcl (Ticlid)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of blood or immune disorders (thrombotic thrombocytopenic purpura, aplastic anemia, agranulocytosis, neutropenia), serious/active bleeding (e.g., bleeding stomach ulcers), severe liver disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver or kidney problems, bleeding/blood clotting disorders,...

Read All Potential Precautions of Ticlid »


Ticlid Consumer (continued)

SIDE EFFECTS: See also the Warning section.

Diarrhea, stomach upset/pain, nausea, vomiting, or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: severe/persistent or bloody diarrhea, vomit that looks like coffee grounds, blood in the urine, bleeding from gums or nose, persistent dizziness.

Tell your doctor immediately if any of these rare but very serious side effects occur: signs of new infection (e.g., chills, persistent sore throat), unusual weakness/fatigue, easy bruising or bleeding, mental/mood changes, numbness/tingling of arms/legs, persistent nausea/vomiting, severe stomach/abdominal pain, change in the amount of urine.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of blood or immune disorders (thrombotic thrombocytopenic purpura, aplastic anemia, agranulocytosis, neutropenia), serious/active bleeding (e.g., bleeding stomach ulcers), severe liver disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver or kidney problems, bleeding/blood clotting disorders, conditions that put you at risk of bleeding (e.g., stomach ulcers), high cholesterol or triglyceride levels.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist that you are taking this medication.

While you are taking this medication, it may take longer than usual for bleeding to stop if you have a cut or injury. Use caution with sharp objects like safety razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.

Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk, but it may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.


Ticlid Patient Information Including Side Effects

Brand Names: Ticlid

Generic Name: ticlopidine (oral) (Pronunciation: tye KLOE pi deen)

  • What is ticlopidine (Ticlid)?
  • What are the possible side effects of ticlopidine (Ticlid)?
  • What is the most important information I should know about ticlopidine (Ticlid)?
  • What should I discuss with my healthcare provider before taking ticlopidine (Ticlid)?
  • How should I take ticlopidine (Ticlid)?
  • What happens if I miss a dose (Ticlid)?
  • What happens if I overdose (Ticlid)?
  • What should I avoid while taking ticlopidine (Ticlid)?
  • What other drugs will affect ticlopidine (Ticlid)?
  • Where can I get more information?

What is ticlopidine (Ticlid)?

Ticlopidine keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Ticlopidine is used to prevent blood clots after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels.

Ticlopidine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of ticlopidine (Ticlid)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using ticlopidine and call your doctor at once if you have a serious side effect such as:

  • nosebleed or other bleeding that will not stop;
  • black, bloody, or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance; or
  • pale skin, easy bruising or bleeding, weakness, fever, and urinating more or less than usual;
  • signs of infection such as fever, chills, sore throat, flu symptoms, mouth sores; or
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • upset stomach, nausea, or vomiting;
  • ringing in your ears;
  • diarrhea;
  • dizziness; or
  • itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ticlopidine (Ticlid)?

You should not use this medication if you are allergic to ticlopidine, or if you have severe liver disease, any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head injury), or a blood cell disorder such as anemia (lack of red blood cells) or low levels of platelets (cells that help your blood clot).

Before taking ticlopidine, tell your doctor if you have a bleeding or blood clotting disorder, a history of stroke, including TIA ("mini-stroke"), a stomach ulcer or ulcerative colitis, high cholesterol or triglycerides, liver disease, or kidney disease.

Because ticlopidine keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using ticlopidine.

While you are taking ticlopidine, do not take aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin) without your doctor's advice.

Taking ticlopidine with certain other drugs can increase your risk of bleeding. Before taking ticlopidine, tell your doctor about all other medications you use.

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