Timolide

(Generic versions may still be available.)

DRUG DESCRIPTION

TIMOLIDE* (Timolol Maleate-Hydrochlorothiazide) is for the treatment of hyper-tension. It combines the antihyper-tensive activity of two agents: a non-selective beta-adrenergic receptor blocking agent (timolol maleate) and a diuretic (hydrochlorothiazide).

Timolol maleate is (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol (Z )-2-butenedioate (1:1) salt. Its empirical formula is C13H24N4O3S_C4H4O4. Its structual formula is:

Timolol maleate has a molecular weight of 432.50. It is a white, odorless, crystalline powder which is soluble in water, methanol, and alcohol.

Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2. Its structual formula is:

Hydrochlorothiazide has a molecular weight of 297.73. It is a white, or practically white, crystalline powder which is slightly soluble in water, but freely soluble in sodium hydroxide solution.

TIMOLIDE (timolol maleate-hydrochlorothiazide) is supplied as tablets containing 10mg of timolol maleate and 25 mg of hydrochlorothiazide for oral administration. Inactive ingredients are cellulose, FD&C Blue 2, magnesium stearate, and starch.

What are the possible side effects of hydrochlorothiazide and timolol (Timolide 10-25)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • swelling, rapid weight gain, feeling short of breath, even with mild exertion;
  • fast, slow, or uneven heartbeat;
  • easy bruising or bleeding;
  • sudden numbness or weakness on one side of the body, problems with...

Read All Potential Side Effects and See Pictures of Timolide

What are the precautions when taking timolol maleate-hydrochlorothiazide (Timolide)?

Consult your...

Read All Potential Precautions of Timolide


Timolide Consumer (continued)

SIDE EFFECTS: Consult your pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Consult your pharmacist.


Timolide Patient Information Including Side Effects

Brand Names: Timolide 10-25

Generic Name: hydrochlorothiazide and timolol (Pronunciation: HYE droe klor oh THYE a zide and TYE moe lol)

  • What is hydrochlorothiazide and timolol (Timolide)?
  • What are the possible side effects of hydrochlorothiazide and timolol (Timolide)?
  • What is the most important information I should know about hydrochlorothiazide and timolol (Timolide)?
  • What should I discuss with my doctor before taking hydrochlorothiazide and timolol (Timolide)?
  • How should I take hydrochlorothiazide and timolol (Timolide)?
  • What happens if I miss a dose (Timolide)?
  • What happens if I overdose (Timolide)?
  • What should I avoid while taking hydrochlorothiazide and timolol (Timolide)?
  • What other drugs will affect hydrochlorothiazide and timolol (Timolide)?
  • Where can I get more information?

What is hydrochlorothiazide and timolol (Timolide)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Timolol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

The combination of hydrochlorothiazide and timolol is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and timolol may also be used for other purposes not listed in this medication guide.

What are the possible side effects of hydrochlorothiazide and timolol (Timolide)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • swelling, rapid weight gain, feeling short of breath, even with mild exertion;
  • fast, slow, or uneven heartbeat;
  • easy bruising or bleeding;
  • sudden numbness or weakness on one side of the body, problems with vision or speech, chest pain, or pain in one or both legs;
  • numbness or tingly feeling in your hands or feet;
  • feeling weak, drowsy, restless, or light-headed;
  • nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions);
  • increased urination, leg discomfort, muscle pain or weakness or limp feeling;
  • urinating less than usual or not at all;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • diarrhea, constipation, upset stomach;
  • dizziness, spinning sensation;
  • depressed mood; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrochlorothiazide and timolol (Timolide)?

You should not use this medication if you have a history of asthma or severe chronic obstructive pulmonary disease (COPD), severe or uncontrolled heart failure, a heart condition called "sick sinus syndrome" or "AV block," an allergy to sulfa drugs, or if you are unable to urinate.

Before using this medication, tell your doctor if you have congestive heart failure, kidney or liver disease, cirrhosis, bronchospastic lung disease, gout, lupus, diabetes, a muscle disorder such as myasthenia gravis, a history of stroke, a thyroid disorder, or if you are allergic to sulfa drugs..

If you are diabetic, check your blood sugar carefully. Using timolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and timolol. Talk with your doctor before changing any doses.

Avoid drinking alcohol, which can lower your blood pressure and may add to the side effects of hydrochlorothiazide and timolol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Keep using this medication even if you feel fine. High blood pressure often has no symptoms.

There are many other medicines that can interact with hydrochlorothiazide and timolol. Tell your doctor about all the prescription and over-the-counter medications you use.

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